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Dietary supplement

Annatto Tocotrienols 125 mg Ingredients & Drug Interactions

by Cardiovascular Research

Annatto Tocotrienols 125 mg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Annatto Tocotrienols 125 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Annatto Tocotrienols 125 mg is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DeltaGOLD. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Annatto Tocotrienols 125 mg by Cardiovascular Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Annatto Tocotrienols 125 mg by Cardiovascular Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Annatto Tocotrienols 125 mg by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tocotrienols (delivered as DeltaGOLD), at 125 mg per softgel. Tocotrienols are a form of vitamin E found naturally in certain plant oils and seeds.

The capsule itself is made from gelatin, glycerin, and water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tocotrienols's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tocotrienols for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

The evidence for tocotrienols is mixed. For type 2 diabetes, there's possibly effective evidence — meaning some studies show promise, but more research is needed.

For high cholesterol, the data suggests it's possibly ineffective. For hair loss (alopecia areata) and breast cancer, there simply isn't enough reliable evidence yet to say whether it works.

The evidence, ingredient by ingredient Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tocotrienols taken by mouth appear to be well tolerated, with no adverse effects reported in clinical trials. That said, long-term safety at supplement doses hasn't been thoroughly established.

During pregnancy, there isn't enough safety data, so it's best to avoid it. While breastfeeding, little is known about safety — talk it over with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Tocotrienols

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs — including warfarin, other anticoagulants, aspirin for heart or stroke protection, clopidogrel, or any other clot-prevention medication — confirm with your doctor or pharmacist before starting this supplement. A Minor interaction is documented, and your healthcare provider needs to weigh the risk for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Annatto Tocotrienols may be worth considering if you're interested in blood sugar support, though the evidence is still emerging. If you take any blood thinner or antiplatelet medication, check with your doctor or pharmacist first — there's a theoretical increased bleeding risk.

Long-term safety data is limited, and it's not recommended during pregnancy or without medical guidance while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Annatto Tocotrienols 125 mg, straight from the product label.

Brand Cardiovascular Research
Barcode (UPC) 696859132070
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 304349
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Annatto Tocotrienols 125 mg by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
696859132070
IngredientAmount% DV
DeltaGOLD125 mg--

Other ingredients: Gelatin, Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

This scientifically designed supplement contains tocotrienols derived from pure rainforest annatto plants.

Formulation

No solvents are used during the extraction process. This product contains no tocopherols.

Gluten free, Casein free

Suggested/Recommended/Usage/Directions

Directions As a dietary supplement, take one softgel daily with an evening meal, or as directed by a physician.

Brand IP Statement(s)

DeltaGOLD is a registered trademark of American River Nutrition, Inc.

General Statements

Ecological Formulas

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Annatto Tocotrienols 125 mg by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Annatto Tocotrienols 125 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Annatto Tocotrienols 125 mg by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

DeltaGOLD

Interacts with
122 drugs
125 mg per serving Form: Tocotrienols

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

DeltaGOLD monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Annatto Tocotrienols 125 mg by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Annatto Tocotrienols 125 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

DeltaGOLD 122

Individual Drug Interactions

The ingredients in Annatto Tocotrienols 125 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Annatto Tocotrienols 125 mg interact with drugs. Each result below shows which ingredient is responsible. DeltaGOLD

Each ingredient & the kinds of drugs it affects

For each ingredient in Annatto Tocotrienols 125 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DeltaGOLD1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
DeltaGOLD full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Annatto Tocotrienols 125 mg, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
Cardiovascular Research, LTD.
Street Address
1061-B Shary Circle
City
Concord
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Annatto Tocotrienols 125 mg by Cardiovascular Research: Common Questions

Does Annatto Tocotrienols 125 mg by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Annatto Tocotrienols 125 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Annatto Tocotrienols 125 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cholesterol?
The evidence suggests tocotrienols are possibly ineffective for high cholesterol. If lowering cholesterol is your main goal, talk with your doctor about other options with stronger evidence.
Can I take this if I'm on aspirin?
Tocotrienols may theoretically increase bleeding risk when combined with aspirin and other blood thinners, though it hasn't been reported in actual patients. Check with your doctor or pharmacist before combining them — they can assess your individual situation.
Is this safe long-term?
Tocotrienols appear well tolerated in studies with no reported adverse effects when taken by mouth, but long-term safety at supplement doses isn't well established. If you plan to use it regularly, discuss that with your healthcare provider.
Can I take this while pregnant?
No, there isn't enough safety information. It's best to avoid supplemental doses during pregnancy and talk it over with your doctor beforehand.
Is it safe to breastfeed while taking this?
Little is known about safety while breastfeeding, so it's wise to avoid it unless your doctor advises otherwise. Check in with them or your pharmacist before starting.
What are tocotrienols?
Tocotrienols are a form of vitamin E found in plant oils and seeds. This product delivers them as DeltaGOLD, a concentrated extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Annatto Tocotrienols 125 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Annatto Tocotrienols 125 mg label
Go deeper

The Full Monographs Behind Annatto Tocotrienols 125 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Annatto Tocotrienols 125 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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