Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Anxiety Soother Holy Basil Ingredients & Drug Interactions

by Herb Pharm

Anxiety Soother Holy Basil label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Anxiety Soother Holy Basil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Anxiety Soother Holy Basil is a dietary supplement by Herb Pharm with 6 active ingredients. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 1,393 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Kava extract, Bacopa monnieri aerial parts extract, Passionflower aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Anxiety Soother Holy Basil by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Anxiety Soother Holy Basil by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Anxiety Soother Holy Basil by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (631 mg) without saying how much of each component you get.

This liquid formula contains 6 active ingredients. Bacopa monnieri aerial parts extract, kava extract, holy basil essential oil extract, lavender flower extract, and passionflower aerial parts extract are all included; one ingredient—albizia bark extract—we could not check our data for.

The product also contains inactive ingredients (certified organic cane alcohol, distilled water, and glycerin) that serve as preservatives and carriers for the herbal extracts.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Anxiety and stress relief.
  • We looked for evidence on: Adjustment disorders, Generalized anxiety disorder (GAD), Perioperative anxiety, Pre-procedural anxiety, Nervousness, Tension — and 2 related terms.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Kava is rated "Possibly Ineffective" for Generalized anxiety disorder (GAD).
  • Also on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Hypertension.

The evidence for what this product can do is limited. For bacopa monnieri, holy basil, and lavender, we hold insufficient reliable evidence to rate their use in anxiety.

Passionflower shows possibly effective evidence for insomnia and pre-procedural anxiety (calming jitters before a procedure), and lavender shows possibly effective evidence for period pain (dysmenorrhea). Kava, meanwhile, rates as possibly ineffective for generalized anxiety disorder despite the product name suggesting otherwise.

Overall, the science supporting this blend for anxiety specifically isn't well established in our data.

The evidence, ingredient by ingredient Bacopa Kava Holy Basil Lavender Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacopa is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are gastrointestinal—abdominal cramps, diarrhea, nausea, and dry mouth—reported in 12% to 30% of study participants.

Some people also report drowsiness, headache, or insomnia. Kava is generally well tolerated short-term but carries a rare but serious risk: over 100 cases of liver injury (hepatotoxicity) have been reported with kava use, especially with long-term or heavy use; symptoms can appear as early as 3 to 4 weeks.

Holy basil, lavender, and passionflower are generally well tolerated; common mild side effects include nausea, loose stools, headache, and dizziness. Passionflower can cause drowsiness and confusion.

For pregnancy: bacopa, kava, holy basil, and passionflower should all be avoided—there isn't enough safety information, or animal data raise concerns. Lavender has not enough reliable safety data, so medicinal amounts should only be used with your doctor's approval.

For breastfeeding: bacopa, kava, holy basil, and passionflower should be avoided due to lack of safety data or because transfer to the infant is possible. Lavender safety while breastfeeding is not well studied; use only with your healthcare provider's guidance.

Side effects, ingredient by ingredient Bacopa Kava Holy Basil Lavender Passion Flower

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Bacopa, Lavender, Passion Flower, Kava, Holy Basil.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,394 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take CNS depressants like sedatives, anti-anxiety drugs, or opioids (Major interaction risk with kava). Also double-check any drug that your liver metabolizes—including many antidepressants, anticonvulsants, and blood pressure medications—because bacopa and kava can affect how your liver processes them (Moderate).

If you take blood thinners, diabetes medications, haloperidol, or ropinirole, those need checking too. Finally, ask your pharmacist about any drug that might cause liver damage if you use kava long-term.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines herbs with limited scientific support for anxiety—in fact, kava rates as possibly ineffective for that purpose. More importantly, if you take any sedating medication, blood thinner, diabetes drug, or medication metabolized by your liver, you need to check your exact prescriptions with the tool on this page before using it.

The kava content carries a rare but real risk of liver damage, especially with long-term use. Talk to your pharmacist before starting, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Anxiety Soother Holy Basil, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700032593
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273146
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Anxiety Soother Holy Basil by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
84
UPC/BARCODE
090700032593
IngredientAmount% DV
Bacopa monnieri aerial parts extract0 NP--
Proprietary Extract Blend631 mg--
Kava extract0 NP--
Holy Basil essential oil extract0 NP--
Lavender Flower Extract0 NP--
Passionflower aerial parts extract0 NP--
Albizia Bark Extract0 NP--

Other ingredients: certified organic Cane Alcohol, Water, Distilled, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Shake well before using. Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 5 times per day. Best taken between meals.

Precautions

Caution: FDA advises that a potential risk of rare, but severe, liver injury may be associated with Kava.

Ask a healthcare professional before use if you have, or have had, liver problems, frequently use alcoholic beverages, or are taking any medication.

Stop use and see a doctor if liver symptoms occur (unusual fatigue, abdominal pain, appetite loss, dark urine, pale stools, yellow eyes or skin).

Not for use by persons under 18 years of age, or by pregnant or breastfeeding women.

Not for use by persons under 18 years of age, or by pregnant or breastfeeding women.

Do not take with alcoholic beverages. Excessive use may briefly impair ability to drive, or operate machinery.

Keep out of the reach of children

Storage

Store away from heat & light

Formulation

Nervous system

Gluten-free

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Anxiety Soother Holy Basil by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Anxiety Soother Holy Basil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Anxiety Soother Holy Basil by Herb Pharm

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container84 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

631 mg per serving

Other (inactive) ingredients: Certified organic Cane Alcohol, Water, Distilled, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Anxiety Soother Holy Basil by Herb Pharm Drug Interactions

Want to check YOUR meds against Anxiety Soother Holy Basil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,393Drugs
248 Major 1,095 Moderate 50 Minor

Ingredients driving the most interactions

Kava extract 1,166
Bacopa monnieri aerial parts extract 930
Passionflower aerial parts extract 836
Lavender Flower Extract 248
Holy Basil essential oil extract 212

Individual Drug Interactions

The ingredients in Anxiety Soother Holy Basil interact with 1,393 drugs. Click any drug to see the details.

5 of the 6 ingredients in Anxiety Soother Holy Basil interact with drugs. Each result below shows which ingredient is responsible. Kava extract Bacopa monnieri aerial parts extract Passionflower aerial parts extract Lavender Flower Extract Holy Basil essential oil extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Anxiety Soother Holy Basil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Kava extract12 drug types · 1,166 drugs

Cns Depressants

Combining kava with CNS depressants can have additive sedative effects.
Kava has CNS depressant effects. Concomitant use of kava with other CNS depressants can increase the risk of drowsiness and motor reflex depression. Clinical practice guidelines from a joint taskforce of the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Treatments (CANMAT) recommend that CNS depressants, including alcohol and benzodiazepines, not be used with kava.

Likelihood Probable Evidence A
Alcohol (Ethanol)

Combining kava with alcohol may increase the risk of sedation and/or hepatotoxicity.

Kava has CNS depressant effects. Concomitant use of kava with other CNS depressants can increase the risk of drowsiness and motor reflex depression. Additionally, kava has been associated with over 100 cases of hepatotoxicity. There is some concern that kava can adversely affect the liver, especially when used in combination with hepatotoxic drugs. Clinical practice guidelines from a joint taskforce of the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Treatments (CANMAT) recommend that alcohol not be used with kava.

Likelihood Possible Evidence A
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, kava might increase levels of CYP2C19 substrates.
In vitro research shows that kava significantly inhibits CYP2C19 enzymes. This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, kava might increase levels of CYP2C9 substrates.
In vitro research shows that kava significantly inhibits CYP2C9 enzymes. This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Kava might increase levels of CYP2E1 substrates.
In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days inhibited the metabolism of CYP2E1 substrates.

Likelihood Probable Evidence B
Haloperidol (Haldol)

Combining kava and haloperidol might increase the risk of cardiovascular adverse effects and hypoxia.
Atrial flutter and hypoxia has been reported for a patient who received intramuscular injections of haloperidol and lorazepam after using kava orally. The side effects were attributed to kava-induced inhibition of CYP2D6, but might also have been related to additive adverse effects with the concomitant use of haloperidol, lorazepam, and kava.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.
Kava has been linked with over 100 cases of hepatotoxicity. Most cases occur with excessive and prolonged use. There is some concern that kava can adversely affect the liver, especially when used in combination with hepatotoxic drugs.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.
In vitro research shows that kava can inhibit P-gp efflux. However, a clinical study in healthy volunteers shows that taking kava standardized to provide 225 mg kavalactones daily for 14 days does not affect the pharmacokinetics of digoxin, a P-gp substrate. It is possible that the use of other P-gp substrates or higher doses of kava might still inhibit P-gp.

Likelihood Possible Evidence D
Ropinirole (Requip)

Taking kava with ropinirole might increase the risk for dopaminergic toxicity.
A case of visual hallucinations and paranoid delusions has been reported for a patient who used kava in combination with ropinirole. The adverse effects were attributed to kava-induced inhibition of CYP1A2, which may have reduced the metabolism of ropinirole, resulting in excessive dopaminergic stimulation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

It is unclear if kava inhibits CYP1A2; research is conflicting.
Although in vitro research and a case report suggest that kava inhibits CYP1A2, more robust clinical evidence shows that kava has no effect on CYP1A2. In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days had no effect on CYP1A2 activity.

Likelihood Unlikely Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

It is unclear if kava inhibits CYP1A2; research is conflicting.
In vitro research shows that kava extract significantly inhibits CYP2D6. However, clinical research shows that kava does not affect the metabolism of CYP2D6 substrates in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if kava inhibits CYP3AA; research is conflicting.
Although in vitro research suggests that kava inhibits CYP3A4, more robust clinical evidence shows that kava has no effect on CYP3A4. In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days had no effect on CYP3A4 activity.

Likelihood Unlikely Evidence B
Kava extract full monograph & interactions

Bacopa monnieri aerial parts extract8 drug types · 930 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Bacopa monnieri aerial parts extract full monograph & interactions

Passionflower aerial parts extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower aerial parts extract full monograph & interactions

Lavender Flower Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.

Likelihood Unlikely Evidence D
Lavender Flower Extract full monograph & interactions

Holy Basil essential oil extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Holy Basil essential oil extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Anxiety Soother Holy Basil, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Anxiety Soother Holy Basil by Herb Pharm: Common Questions

Does Anxiety Soother Holy Basil by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Anxiety Soother Holy Basil has a known interaction with 1,393 medications, including 248 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Anxiety Soother Holy Basil contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Yes, it likely will. Kava, passionflower, and lavender all have sedative effects, and drowsiness is a commonly reported side effect. You shouldn't drive or operate machinery until you know how you react to it.
Can I take this if I'm pregnant or breastfeeding?
No. Bacopa, kava, holy basil, and passionflower should be avoided during pregnancy because there isn't enough safety data or animal studies raise concerns. All five should be avoided while breastfeeding. Talk to your doctor about safer options.
What are the most common side effects?
Gastrointestinal upset—nausea, diarrhea, abdominal cramps, dry mouth—is most frequent, reported by a significant portion of people taking bacopa. Drowsiness, dizziness, and headache are also common. Most are mild, but if side effects persist or worsen, stop and talk to your pharmacist.
Is kava safe to use long-term?
Kava has been linked to rare but serious liver injury, with over 100 reported cases worldwide. Risk is highest with long-term or heavy use; symptoms can show up as early as 3 to 4 weeks. It's not recommended for routine, extended use.
Does passionflower actually help with anxiety?
The data we hold shows passionflower is possibly effective for insomnia and pre-procedural anxiety (calming before medical procedures), not general anxiety. Evidence for bacopa, holy basil, and lavender in anxiety is insufficient—not proven yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Anxiety Soother Holy Basil label
Go deeper

The Full Monographs Behind Anxiety Soother Holy Basil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph → Herb & supplement monograph

Kava

Interacts with 1,166 drugs

Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety. However, kava has been linked to rare but serious...

Read the full Kava monograph → Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph → Herb & supplement monograph

Lavender

Interacts with 248 drugs

Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...

Read the full Lavender monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Anxiety Soother Holy Basil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 130 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
  3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
  4. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
  5. Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
  6. Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
  7. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
  8. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
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Lavender 20 references
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Passion Flower 19 references
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