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Dietary supplement

Arjuna Ingredients & Drug Interactions

by Bixa Botanical

Arjuna label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Arjuna against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Arjuna is a dietary supplement by Bixa Botanical with 1 active ingredient. Its ingredients are commonly taken for heart health and circulation, digestive problems (constipation, diarrhea), cholesterol support.Based on those ingredients, 933 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Terminalia arjuna extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Arjuna by Bixa Botanical

Ask about any prescription or over-the-counter medication and we check it for interactions with Arjuna by Bixa Botanical — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Arjuna by Bixa Botanical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Arjuna contains one active ingredient: Terminalia arjuna extract, a plant-derived compound traditionally used in Ayurvedic medicine for heart and circulatory support. The capsule itself is made from HPMC, a plant-based vegetarian capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Terminalia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cardiac wellbeing.
  • We looked for evidence on: Angina, Coronary heart disease (CHD), Heart failure, Hypertension, Hyperlipidemia, cardiovascular health — and 1 related terms.
  • The closest evidence on file: Terminalia is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Terminalia is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Heart failure, Hyperlipidemia, Hypertension.

The evidence for Arjuna is currently insufficient to reliably rate its effectiveness for its traditional uses. Studies have looked at it for high cholesterol (hyperlipidemia), high blood pressure (hypertension), angina (chest pain), and weight management (obesity), but we don't yet have enough solid research data to say whether it actually works for these purposes.

The evidence, ingredient by ingredient Terminalia

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Terminalia arjuna extract is generally well tolerated in the short term in studies, though long-term safety isn't well established and quality varies between products. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations.

No specific adverse effects were reported in the trials we have on file.

Side effects, ingredient by ingredient Terminalia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Terminalia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 934 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications with your doctor or pharmacist, especially if you take blood thinners or antiplatelet drugs (increased bleeding risk), diabetes medications (increased low blood sugar risk), or any drugs broken down by your liver's CYP2D6, CYP2C9, or CYP3A4 enzymes — a very common group that includes many heart and mental-health medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Arjuna may appeal to people interested in traditional heart and circulatory support, but the effectiveness evidence is still being built. Because it interacts with a very large number of medications — especially blood thinners, diabetes drugs, and medications your liver processes — you'll want to check your exact prescriptions with your doctor or pharmacist before starting.

It's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Arjuna, straight from the product label.

Brand Bixa Botanical
Barcode (UPC) X001AQ3KE7
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228896
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Arjuna by Bixa Botanical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
X001AQ3KE7
IngredientAmount% DV
Terminalia arjuna extract450 NP--

Other ingredients: HPMC Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: This product is not intended for use by those with serious medical condition or pregnant or lactating women. Consult your physician before use.

Keep out of reach of children.

Do not use if seal is broken.

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration and this product is a food supplement and not intended to diagnose treat or cure or prevent any disease.

Seals/Symbols

Vegan Halal K LBD (Kosher) Good manufacturing practices GMP

Formulation

Vegan

For cardiac wellbeing

Formula

K LBD (Kosher)

Halal

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 1 capsules 2 times daily after food or as directed by physician

Storage

Store in a cool and dry place.

General Statements

Neutral code: MP/25D/9/89

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Arjuna by Bixa Botanical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Arjuna label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Arjuna by Bixa Botanical

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Terminalia arjuna extract

Interacts with
933 drugs
450 NP per serving Form: Tannins

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes....

Terminalia arjuna extract monograph & interactions

Other (inactive) ingredients: HPMC Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Arjuna by Bixa Botanical Drug Interactions

Want to check YOUR meds against Arjuna?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
933Drugs
933 Moderate

Ingredients driving the most interactions

Terminalia arjuna extract 933

Individual Drug Interactions

The ingredients in Arjuna interact with 933 drugs. Click any drug to see the details.

1 of the 1 ingredient in Arjuna interact with drugs. Each result below shows which ingredient is responsible. Terminalia arjuna extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Arjuna with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Terminalia arjuna extract7 drug types · 933 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.

Likelihood Possible Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.

Likelihood Possible Evidence D
Omeprazole (Prilosec)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.

Likelihood Possible Evidence D
Terminalia arjuna extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Arjuna, from the product label.

Bixa Botanical

See all Bixa Botanical products
Name
Jairamdass Khushiram
Street Address
Plot No - M -14/14-1, MIDC, Taloja
City
410 208 Maharasthra
Phone Number
00-91-22-2783 1232
Web Address
www.bixabotanical.com
Pharmacist Counseling Corner

Arjuna by Bixa Botanical: Common Questions

Does Arjuna by Bixa Botanical interact with any medications?
Yes. Based on its ingredients, Arjuna has a known interaction with 933 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Arjuna contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Terminalia arjuna extract?
It's a plant extract from the Terminalia arjuna tree, used traditionally in Ayurvedic medicine. The extract is the active ingredient in this product and is the source of its interactions with medications and potential effects on heart health and blood flow.
Does Arjuna actually work?
We don't have enough solid research to say yet. Studies have looked at it for high cholesterol, high blood pressure, angina, and weight management, but the evidence is currently insufficient to reliably rate whether it works for these purposes.
Is Arjuna safe to take long-term?
Short-term safety looks generally okay in studies, but long-term safety isn't well established. Product quality also varies between brands, so consistency is uncertain if you plan to use it over time.
Can I take Arjuna if I'm pregnant or breastfeeding?
No — the safety data advises against it. There isn't enough information to know whether it's safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist for personalized guidance.
Why does this product interact with so many medications?
Terminalia arjuna extract slows down three major enzymes in your liver that break down many common drugs. When those enzymes are slower, medications can build up to higher levels in your body, which raises the risk of side effects. It also has blood-thinning effects and can lower blood sugar.
What adverse effects might I experience?
We don't have adverse effects on file from the trials we hold, and short-term use appears generally well tolerated. However, because of the liver enzyme and blood-thinning interactions, your main risk is with how other medications behave, not the Arjuna itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Arjuna label
Go deeper

The Full Monographs Behind Arjuna’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Terminalia

Interacts with 933 drugs

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...

Read the full Terminalia monograph →
Sources

Sources & How We Checked

Arjuna's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Terminalia 9 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
  3. Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
  4. Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
  5. Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
  6. Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
  7. Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
  8. Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
  9. Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed

See these in context on the Terminalia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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