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Dietary supplement

Artemisia Annua Ingredients & Drug Interactions

by NutraMedix

Artemisia Annua label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artemisia Annua against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artemisia Annua is a dietary supplement by NutraMedix with 1 active ingredient. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sweet Annie Herb Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artemisia Annua by NutraMedix

Ask about any prescription or over-the-counter medication and we check it for interactions with Artemisia Annua by NutraMedix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artemisia Annua by NutraMedix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Sweet Annie herb extract. It's a liquid made from Sweet Annie (also called Artemisia annua), a plant traditionally used in herbal medicine.

The product also contains mineral water and ethanol as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sweet Annie's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Microbial support.
  • We looked for evidence on: Malaria.
  • The closest evidence on file: Sweet Annie is rated "Insufficient Reliable Evidence To Rate" for Malaria (Natural Medicines).

The evidence we hold shows Sweet Annie may be helpful for hay fever (allergic rhinitis), though more research is needed to be sure. For other uses — liver disease (nonalcoholic fatty liver disease), malaria, and osteoarthritis — the evidence isn't yet established enough for us to rate it.

If hay fever is what you're considering this for, talk with us about whether the available evidence matches what you're looking for.

The evidence, ingredient by ingredient Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, Sweet Annie is generally well tolerated, though nausea and vomiting are the most common side effects people report. Rarely, it has caused liver damage — one person developed hepatitis after taking a related compound for 10 days, though that case isn't definitive.

A mild allergic reaction (rash and cough) has been reported in one person. Because quality and dose vary widely, this supplement shouldn't replace treatments your doctor has prescribed.

The safety data advises against it during pregnancy because of possible harm to the developing baby, and there isn't enough safety information to know whether it's okay while breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • For scale: 890 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check any medications you're on that are processed by your liver — especially drugs that already stress the liver, and those broken down by the CYP3A4 or CYP2B6 enzymes. Sweet Annie may change how well these medications work.

Run your prescriptions through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Sweet Annie extract is generally well tolerated for short-term use and may help with hay fever, but it interacts with a large number of common medications by affecting how your liver processes them and by potentially stressing your liver itself. If you take any prescription drugs or have liver problems, check your medications with us before starting.

Talk with your pharmacist or doctor to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artemisia Annua, straight from the product label.

Brand NutraMedix
Barcode (UPC) 728650011923
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 334020
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artemisia Annua by NutraMedix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
30 Drop(s)
Servings per container
40
UPC/BARCODE
728650011923
IngredientAmount% DV
Sweet Annie Herb Extract1.5 mL--

Other ingredients: Mineral Water, Ethanol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before each use. Put 1 to 30 drops in 4 oz (120 mL) of water and wait one minute before drinking. Start with 1 drop (30 min before meals) increasing slowly up to 30 drops, 2-4 times a day or as directed by physician.

Precautions

Do not use if pregnant or nursing.

Stop use if adverse reactions develop.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Microbial support

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artemisia Annua by NutraMedix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artemisia Annua label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artemisia Annua by NutraMedix

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container40 Amounts shown are per serving.

Sweet Annie Herb Extract

Interacts with
889 drugs
1.5 mL per serving

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...

Sweet Annie Herb Extract monograph & interactions

Other (inactive) ingredients: Mineral Water, Ethanol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artemisia Annua by NutraMedix Drug Interactions

Want to check YOUR meds against Artemisia Annua?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
889Drugs
889 Moderate

Ingredients driving the most interactions

Sweet Annie Herb Extract 889

Individual Drug Interactions

The ingredients in Artemisia Annua interact with 889 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artemisia Annua interact with drugs. Each result below shows which ingredient is responsible. Sweet Annie Herb Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artemisia Annua with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sweet Annie Herb Extract3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Sweet Annie Herb Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artemisia Annua, from the product label.

NutraMedix

See all NutraMedix products
Name
NutraMedix
City
Jupiter
State
Florida
ZipCode
33458
Phone Number
561-745-2917
Web Address
www.nutramedix.com
Pharmacist Counseling Corner

Artemisia Annua by NutraMedix: Common Questions

Does Artemisia Annua by NutraMedix interact with any medications?
Yes. Based on its ingredients, Artemisia Annua has a known interaction with 889 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artemisia Annua contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No — the safety data advises against it because of possible harm to the developing baby. Talk with your doctor about what's safe for you.
Is it safe to breastfeed while taking Sweet Annie?
There isn't enough safety information to know either way. Talk with your doctor or pharmacist for personalized advice before using this while breastfeeding.
What side effects might I notice?
Nausea and vomiting are the most common. Rarely, people have reported liver damage or mild allergic reactions like a rash and cough. Stop and call us if you develop abdominal pain, dark urine, or signs of an allergic reaction.
Does it actually work for hay fever?
The evidence suggests it may help, but more research is needed to be certain. If you're considering it for that, we can discuss whether it's a reasonable choice for you.
Why shouldn't I use this instead of my prescribed treatments?
Quality and dose vary widely in this supplement, and your prescribed treatments have been tested and proven to work. Sweet Annie can't be counted on to replace them.
Why does it interact with so many drugs?
Sweet Annie affects the liver enzymes that break down many common medications — particularly CYP3A4 and CYP2B6 — so changes to how you metabolize those drugs are possible. That's why it's important to check your specific medications before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artemisia Annua is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artemisia Annua label
Go deeper

The Full Monographs Behind Artemisia Annua’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

Artemisia Annua's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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