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Dietary supplement

Artichoke Ingredients & Drug Interactions

by Herb Pharm

Artichoke label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 364 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient, artichoke leaf extract, made from the artichoke plant. The inactive ingredients are cane alcohol and distilled water, which are the carrier components of the liquid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: System restoration: cardio and circulatory support.
  • We looked for evidence on: Hyperlipidemia, Hypertension, Cardiovascular disease, Circulatory health, Atherosclerosis, Blood pressure.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Hypertension.

Artichoke leaf extract is rated possibly effective for hyperlipidemia (high levels of fats in the blood) and for dyspepsia (indigestion). For nonalcoholic fatty liver disease, there is insufficient reliable evidence to rate its effect, so that benefit is not established in the data we hold.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The product is generally well tolerated as a food and short-term supplement, though quality and dosing vary by product. Common side effects taken orally include abdominal pain, diarrhea, gas, hunger, and nausea.

Rare but serious reactions, including anaphylaxis (a severe allergic reaction), have been reported in people sensitive to artichoke inulin, and people sensitive to ragweed, daisies, or marigolds may be at greatest risk of allergic reactions. Our safety notes advise avoiding this supplement form during pregnancy because there isn't enough safety information, and they say breastfeeding safety has not been established, so it is best avoided.

Please talk with your own doctor or pharmacist about your situation.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 364 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check antihypertensive drugs (blood pressure medicines) and antidiabetes drugs (diabetes medicines), both rated Moderate. Also review drugs metabolized by CYP2C19 and CYP2B6 (liver enzymes), also rated Moderate.

Confirm any of these with your own doctor or pharmacist before combining them with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you are looking into artichoke for cholesterol or indigestion, the possibly effective ratings may be worth a conversation with your doctor. If you take blood pressure or diabetes medicines, be careful and check with your doctor or pharmacist before using it.

If you are pregnant or breastfeeding, talk with your own healthcare provider before considering this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700003364
Net contents 1 Fluid Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 327348
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
42
UPC/BARCODE
090700003364
IngredientAmount% DV
Artichoke Leaf Extract669 mg--

Other ingredients: Cane Alcohol, Water, Distilled

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before use Adults: Add 1 squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 3 times per day. Best taken between meals.

Precautions

Keep out of the reach of children

Storage

Store away from heat & light

Formula

Cynara cardunculus

Formulation

System restoration Cardio & circulatory

USDA Organic

Gluten-free

Certified organic by Organic Certifiers

Seals/Symbols

Regenerative organic certified RO Silver USDA Organic

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.

Artichoke Leaf Extract

Interacts with
364 drugs
669 mg per serving Form: Cynara cardunculus Leaf Extract

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke Leaf Extract monograph & interactions

Other (inactive) ingredients: Cane Alcohol, Water, Distilled. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artichoke by Herb Pharm Drug Interactions

Want to check YOUR meds against Artichoke?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
364Drugs
364 Moderate

Ingredients driving the most interactions

Artichoke Leaf Extract 364

Individual Drug Interactions

The ingredients in Artichoke interact with 364 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artichoke interact with drugs. Each result below shows which ingredient is responsible. Artichoke Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke Leaf Extract4 drug types · 364 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Artichoke by Herb Pharm: Common Questions

Does Artichoke by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Artichoke has a known interaction with 364 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take while pregnant?
Our safety notes advise avoiding this supplement form during pregnancy because there isn't enough safety information to be confident. Please talk with your own doctor or pharmacist for advice about your situation.
What side effects can artichoke leaf extract cause?
The most common side effects taken orally are abdominal pain, diarrhea, gas, hunger, and nausea. Serious allergic reactions are rare but have been reported, especially in people sensitive to artichoke inulin.
Does artichoke leaf extract work for indigestion?
It is rated possibly effective for dyspepsia (indigestion). That is a lower level of evidence than a proven effect, so it is worth discussing with your doctor.
Does this product help with fatty liver disease?
We have insufficient reliable evidence to rate artichoke leaf extract for nonalcoholic fatty liver disease, so its benefit there is not established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artichoke is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke label
Go deeper

The Full Monographs Behind Artichoke’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 364 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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