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Dietary supplement

Ashwagandha Root Powder Ingredients & Drug Interactions

by Organic Traditions

Ashwagandha Root Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ashwagandha Root Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ashwagandha Root Powder is a dietary supplement by Organic Traditions with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Ashwagandha (Withania somnifera) root powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ashwagandha Root Powder by Organic Traditions

Ask about any prescription or over-the-counter medication and we check it for interactions with Ashwagandha Root Powder by Organic Traditions — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ashwagandha Root Powder by Organic Traditions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic ashwagandha (Withania somnifera) root powder. There are no inactive ingredients listed.

You're getting the dried root in powder form, which you can mix into water, juice, or food.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: traditional ayurvedic tonic for general well-being.
  • We looked for evidence on: Stress, Anxiety, Generalized anxiety disorder (GAD), Fatigue, Insomnia, Athletic performance — and 4 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Ashwagandha is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chemotherapy-related fatigue, Fatigue.

Ashwagandha shows possibly effective evidence for insomnia, anxiety, stress, and generalized anxiety disorder. The research is still limited, so it's not a slam-dunk, but there's enough preliminary clinical work to suggest it may help with these conditions.

For bipolar disorder, the evidence just isn't reliable enough yet to rate it either way.

The evidence, ingredient by ingredient Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use in healthy adults is generally well tolerated. The most common side effects when they do occur are diarrhea, gastrointestinal upset, nausea, and vomiting—but these don't typically happen at normal doses.

Drowsiness has been reported. Rare serious effects include acute liver damage and hepatitis, so if you notice yellowing skin or eyes, dark urine, or severe abdominal pain, stop and contact your doctor right away.

Avoid ashwagandha if you're pregnant—it's traditionally thought to raise the risk of miscarriage. Don't take it while breastfeeding either, because there isn't enough safety data.

Long-term safety data are also limited, so quality and duration of use should be discussed with your pharmacist or doctor.

Side effects, ingredient by ingredient Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,373 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check before starting if you take medications that affect your liver (hepatotoxic drugs), sleep aids or sedatives (CNS depressants or benzodiazepines), blood pressure medications (antihypertensives), diabetes drugs, thyroid hormone replacement, immunosuppressants, or drugs your liver processes via CYP1A2. All of these carry documented interactions ranging from Moderate to Minor severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ashwagandha may help with anxiety, stress, and sleep, and most people tolerate it well short-term. But it interacts with a wide range of medications—especially blood pressure drugs, sedatives, diabetes medications, thyroid replacements, and drugs that affect your liver.

Check your exact medications with our tool before you start, and talk to your pharmacist if you're on anything for mood, sleep, blood pressure, or blood sugar.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ashwagandha Root Powder, straight from the product label.

Brand Organic Traditions
Barcode (UPC) 627733003902
Net contents 7 oz.; 200 Gram(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 57173
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ashwagandha Root Powder by Organic Traditions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
40
UPC/BARCODE
627733003902
IngredientAmount% DV
organic Ashwagandha (Withania somnifera) root powder5 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Premium Superfoods Conscious Sourcing

General Statements

Amazing Superherb

See organictraditions.com for more great superfoods

Resealable

Super Herbs

Ashwagandha Root Powder Ashwagandha Root Powder is also known as Indian Ginseng because its actions and uses are similar to those of Chinese Ginseng. While it is one of the most commonly used roots in Traditional Ayurvedic Medicine for increased stamina, it has also been used to promote a calm mind and encourage sleep. It is extensively used in India as a daily tonic and home remedy. Its Sanskrit name means “that which imparts the strength of a stallion,” a name that suggests its traditional usage.

Cultivated in India for thousands of years, the fruit has been used in Traditional Ayurvedic Medicine as an everyday rejuvenating tonic as well as for daily, gentle cleansing.* Amla berry powder has a naturally tart, citrus like taste.

Organic Nutrition From Around The World At Organic Traditions we provide nutrient dense superfoods from many healing traditions. We are committed to supporting farmers who are dedicated to the principles of sustainable and fair trade agriculture. Now more than ever we need to nourish ourselves with superfoods, herbs, seeds and fruits packed with the nutrition needed to support the challenges that come with living in a fast paced world. Be adventurous. These superfoods are versatile. Incorporate them into recipes in any creative way you see fit. At every meal you have the opportunity to choose dense nutrition. Food is powerful. Make choices for a better you and a better planet.

Suggested/Recommended/Usage/Directions

Add to Water Coconut Water & Juice Smoothies & Tonics Yogurt & Berries Desserts & More

Add 1 teaspoon of Ashwagandha powder to water, coconut water, juice, smoothies, desserts, artisanal chocolate bars, on top of yogurt or in any other recipe. Create a delicious smoothie by blending 1-2 Teaspoons of Ashwagandha with Organic Traditions Sprouted Chia Powder, Organic Traditions Shredded Coconut, Organic Traditions Maca X-6, Organic Traditions Goji Berries, Natural Traditions Rice Bran and Germ, Organic Traditions Golden Berries, Organic Traditions Baobab Powder, Organic Traditions Chlorella & Spirulina, Organic Traditions Wheat Grass Juice Powder, Organic Traditions Vanilla Powder and any other Organic Traditions Superfoods of Superfruits with sufficient water (3-6 cups) to achieve the desired consistency.

Take one teaspoon of Amla as a tonic once daily. Add to water, coconut water, juice, herbal tea and smoothies or yogurt, raw desserts, on top of berries or any other recipe. Create a delicious Amla smoothie by blending 1-2 teaspoons of Amla Berry Powder with Organic Traditions Sprouted Chia Powder, Organic Traditions Shredded Coconut, Organic Traditions Goji Berries, Organic Traditions Golden Berries, Organic Traditions Baobab Powder, Organic Traditions Vanilla Powder, Organic Traditions Yacon Nectar as a natural sweetener and any other Organic Traditions or Natural Traditions Superfoods with sufficient water (3-6 cups) to achieve the desired consistency. For a more concentrated form of Ashwagandha use Organic Traditions Ashwagandha Smoothie Booster powder with is a dual extract of supercritical CO2 and hydroethanolic extract in an easy to use, semi-soluble powder.

Seals/Symbols

Sanskrit name means "That which imparts the strength of a stallion" Sustainably grown and harvested A traditional ayurvedic tonic

Eat Well - Live Well Food Is Powerful Vibrant Living

ECO CERT BY ECOCERT ICO

USDA ORGANIC

KOSHER OU

VEGAN

RAW

Formula

Ashwagandha Root Powder

May contain tree nuts.

While it can be used as an everyday tonic it is particularly beneficial during cold and flu season and in times of stress due to its high content of Vitamin C.

- Withania somnifera -

Precautions

Produced in a facility that processes tree nuts. May contain tree nuts.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Certified organic by: Ecocert ICO

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ashwagandha Root Powder by Organic Traditions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ashwagandha Root Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ashwagandha Root Powder by Organic Traditions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Organic Ashwagandha (Withania somnifera) root powder

Interacts with
1,372 drugs
5 Gram(s) per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Organic Ashwagandha (Withania somnifera) root powder monograph & interactions
Interaction report

Ashwagandha Root Powder by Organic Traditions Drug Interactions

Want to check YOUR meds against Ashwagandha Root Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,372Drugs
916 Moderate 456 Minor

Ingredients driving the most interactions

organic Ashwagandha (Withania somnifera) root powder 1,372

Individual Drug Interactions

The ingredients in Ashwagandha Root Powder interact with 1,372 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ashwagandha Root Powder interact with drugs. Each result below shows which ingredient is responsible. organic Ashwagandha (Withania somnifera) root powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Ashwagandha Root Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Ashwagandha (Withania somnifera) root powder10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
organic Ashwagandha (Withania somnifera) root powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ashwagandha Root Powder, from the product label.

Organic Traditions

See all Organic Traditions products
Name
Health Matters America Inc.
Street Address
2501 Broadway St., Unit 2
City
Cheektowaga
State
NY
ZipCode
14227
Phone Number
1-888-343-3278
Web Address
www.organictraditions.com
Pharmacist Counseling Corner

Ashwagandha Root Powder by Organic Traditions: Common Questions

Does Ashwagandha Root Powder by Organic Traditions interact with any medications?
Yes. Based on its ingredients, Ashwagandha Root Powder has a known interaction with 1,372 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ashwagandha Root Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ashwagandha if I'm pregnant or breastfeeding?
No—the safety data advises against it during pregnancy because it's traditionally thought to risk miscarriage. While breastfeeding, there isn't enough safety information, so you should avoid it then too. Talk to your doctor or pharmacist if you're planning pregnancy or nursing and want to use ashwagandha.
What are the most common side effects?
Diarrhea, stomach upset, nausea, and vomiting are the most common, though they don't usually happen at typical doses. Drowsiness has also been reported. If you notice more serious symptoms like yellowing of the skin or eyes, dark urine, or severe belly pain, stop and contact your doctor—these could be signs of liver problems.
Does ashwagandha actually work for sleep and anxiety?
The evidence is still developing, but it looks possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder based on preliminary clinical research. It's not a guarantee, but there's enough reason to think it may help some people.
How should I take this powder?
The product facts don't specify dosing instructions, so follow the label on your package or ask your pharmacist. You can mix it into water, juice, tea, or food depending on your preference.
Is this safe to take long-term?
The safety data for long-term use are limited. Short-term use in healthy adults is generally well tolerated, but there isn't enough research on what happens with years of regular use. Talk to your pharmacist about how long you plan to take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ashwagandha Root Powder label
Go deeper

The Full Monographs Behind Ashwagandha Root Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Ashwagandha Root Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
  17. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
  18. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
  19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
  20. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
  21. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
  22. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
  23. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  24. Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
  25. Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
  26. Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
  27. Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
  28. Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
  29. Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 2023;7(10):e0270. PubMed
  30. Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
  31. Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
  32. Patel M, Newell R, Hillier M, Ramalingam R. Herbal remedies as a potential cause of hypoadrenalism. Br J Hosp Med (Lond) 2024;85(6):1-4. PubMed

See these in context on the Ashwagandha monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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