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Dietary supplement

Astaxanthin Soft Gels 12 mg Ingredients & Drug Interactions

by Chief Originals

Astaxanthin Soft Gels 12 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Astaxanthin Soft Gels 12 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Astaxanthin Soft Gels 12 mg is a dietary supplement by Chief Originals with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are AstaZine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Astaxanthin Soft Gels 12 mg by Chief Originals

Ask about any prescription or over-the-counter medication and we check it for interactions with Astaxanthin Soft Gels 12 mg by Chief Originals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Astaxanthin Soft Gels 12 mg by Chief Originals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: astaxanthin, a carotenoid (a natural pigment compound) delivered as 12 mg per softgel. The inactive ingredients are safflower oil, gelatin, glycerin, water, a natural haematococcus pluvialis extract (the algae source of astaxanthin), medium chain triglyceride, and vitamin E (d-alpha-tocopherol).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports joint, eye, cardiovascular and skin health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Aging skin, Dry eye, Exercise-induced muscle damage, Exercise-induced muscle soreness, Heart failure — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Heart failure, Dry eye, Exercise-induced muscle soreness, and more.

The evidence we hold for astaxanthin does not establish its effectiveness for the conditions listed — age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome all carry an "Insufficient Reliable Evidence To Rate" designation. That means the studies available are too limited or unclear to say whether it works.

The evidence, ingredient by ingredient Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported are abdominal pain, diarrhea, and red-colored stools.

At the 12 mg dose in this product, these effects are uncommon; higher doses (40 mg daily) have caused severe stomach pain in a small number of people. The safety data advise against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations.

Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check your medications against any that are metabolized by CYP3A4 or CYP2B6 enzymes. This is a large group — statins, some blood pressure medications, immunosuppressants, and many psychiatric drugs fall into these categories.

The interaction checker below will flag your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Astaxanthin may be worth considering if you're interested in a supplement for general wellness, since it's generally well tolerated at this dose. If you take any medications your liver processes — especially statins, blood pressure drugs, or certain psychiatric medications — check with us first.

Avoid it during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Astaxanthin Soft Gels 12 mg, straight from the product label.

Brand Chief Originals
Barcode (UPC) 050742581145
Net contents 50 Softgel(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307944
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Astaxanthin Soft Gels 12 mg by Chief Originals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
50
UPC/BARCODE
050742581145
IngredientAmount% DV
Calories15 Calorie(s)--
AstaZine12 mg--

Other ingredients: Astaxanthin, Natural, Safflower Oil, Gelatin, Glycerin, Water, Haematococcus pluvialis Extract, Natural, Medium Chain Triglyceride, D-Alpha-Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Astaxanthin is one of nature's strongest antioxidants and has demonstrated a number of benefits during human clinical trials. Astaxanthin supports joint and tendon health, eye health, cardiovascular health, recovery from exercise and skin health during exposure to the sun and UV rays.

Precautions

Always consult your healthcare practitioner before using if you are pregnant or nursing. If pregnant or under a doctor's care, consult your physician before using this product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Do not use if the safety seal is broken.

Keep out of reach of children.

Manufactured in a facility which may contain nuts (peanuts, tree nuts).

Formulation

Our Astaxanthin soft gels are free of GMOs, gluten, yeast, corn, lactose, wheat, and BSE.

Glyphosate tested Non-GMO No radiation

Laboratory verified

Seals/Symbols

Natural Algae Astaxanthin Verified NAXA AstaZine Glyphosate tested Laboratory verified

Suggested/Recommended/Usage/Directions

One per day formula

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Astaxanthin Soft Gels 12 mg by Chief Originals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Astaxanthin Soft Gels 12 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Astaxanthin Soft Gels 12 mg by Chief Originals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container50 Amounts shown are per serving.

AstaZine

Interacts with
671 drugs
12 mg per serving Form: Astaxanthin, Natural

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

AstaZine monograph & interactions

Other (inactive) ingredients: Astaxanthin, Natural, Safflower Oil, Gelatin, Glycerin, Water, Haematococcus pluvialis Extract, Natural, Medium Chain Triglyceride, D-Alpha-Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Astaxanthin Soft Gels 12 mg by Chief Originals Drug Interactions

Want to check YOUR meds against Astaxanthin Soft Gels 12 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

AstaZine 671

Individual Drug Interactions

The ingredients in Astaxanthin Soft Gels 12 mg interact with 671 drugs. Click any drug to see the details.

1 of the 1 ingredient in Astaxanthin Soft Gels 12 mg interact with drugs. Each result below shows which ingredient is responsible. AstaZine

Each ingredient & the kinds of drugs it affects

For each ingredient in Astaxanthin Soft Gels 12 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

AstaZine2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
AstaZine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Astaxanthin Soft Gels 12 mg, from the product label.

Chief Originals

See all Chief Originals products
Name
Chief Originals LLC
Street Address
3820 Central Ave. Unit #109
City
Cheyenne
State
WY
ZipCode
82001
Phone Number
1-888-959-6415
Web Address
chieforiginals.com
Pharmacist Counseling Corner

Astaxanthin Soft Gels 12 mg by Chief Originals: Common Questions

Does Astaxanthin Soft Gels 12 mg by Chief Originals interact with any medications?
Yes. Based on its ingredients, Astaxanthin Soft Gels 12 mg has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Astaxanthin Soft Gels 12 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is astaxanthin?
Astaxanthin is a carotenoid — a natural pigment — that gives certain algae and seafood their reddish color. It's an antioxidant, meaning it helps neutralize harmful molecules in the body. This product delivers 12 mg per softgel.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against it during pregnancy and breastfeeding because there isn't enough information to know whether it's safe. Talk with your doctor or pharmacist about what's best for your situation.
What side effects might I notice?
At this 12 mg dose, side effects are uncommon, but abdominal pain, diarrhea, and red-colored stools have been reported. These are mild and usually temporary.
Does astaxanthin actually work for anti-aging or brain health?
The evidence we hold doesn't establish that it works for aging skin, cognitive decline, Alzheimer disease, or the other conditions listed. The studies available are too limited to say either way.
Is this product safe long-term?
Astaxanthin is generally well tolerated in the studies we have, but long-term safety data are limited. If you plan to take it regularly for months or years, ask your pharmacist whether that's the right choice for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Astaxanthin Soft Gels 12 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Astaxanthin Soft Gels 12 mg label
Go deeper

The Full Monographs Behind Astaxanthin Soft Gels 12 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Astaxanthin Soft Gels 12 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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