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Dietary supplement

B-12 Methylcobalamin 1000 mcg Red Raspberry Ingredients & Drug Interactions

by KAL

B-12 Methylcobalamin 1000 mcg Red Raspberry label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B-12 Methylcobalamin 1000 mcg Red Raspberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

B-12 Methylcobalamin 1000 mcg Red Raspberry is a dietary supplement by KAL with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin B12 in the methylcobalamin form, dosed at 1000 mcg per tablet. The rest is inactive ingredients — mannitol, starch, cellulose, sorbitol, raspberry flavor, magnesium stearate, citric acid, sodium bicarbonate, polysaccharides, silica, and stevia — which are fillers, binders, and flavoring to make the tablet work and taste better.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Vitamin B12's overall clinical evidence instead.

Strong

Strong clinical evidence supports Vitamin B12 for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Natural Medicines).
  • On file: Cyanide poisoning — rated "Likely Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).
  • On file: Postherpetic neuralgia — rated "Possibly Effective" (Natural Medicines).

Vitamin B12 is effective for treating established B12 deficiency and Imerslund-Grasbeck disease, a rare genetic condition that impairs B12 absorption. It's also likely effective for cyanide poisoning when used under medical supervision.

For canker sores and postherpetic neuralgia (nerve pain after shingles), the evidence is possibly effective — meaning there's some promise, but more research is needed to be sure.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally well-tolerated when taken by mouth. It's very safe overall and has no upper limit because your body clears excess through urine.

Serious side effects are rare; the main concern is allergic reactions in sensitive individuals — rash, itching, or hives — especially if you have a cobalt allergy. B12 is both needed and considered safe during pregnancy and breastfeeding at recommended amounts, so follow your doctor's guidance on dosing.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Metformin (Glucophage) is the main one to double-check. If you take it for diabetes, B12 supplementation may help offset the vitamin's lower absorption, but talk to your doctor or pharmacist about the right timing and dose.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

This supplement is a straightforward, well-tolerated B12 option if you have a deficiency or are at risk for one — especially if you're vegan, have absorption issues, or take metformin long-term. If you're on metformin, check with your provider about whether B12 monitoring or supplementation makes sense for you.

As always, run your exact medications through our checker before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B-12 Methylcobalamin 1000 mcg Red Raspberry, straight from the product label.

Brand KAL
Net contents 90 Micro Tablet(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 207725
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Vitamin B121000 mcg16667%

Other ingredients: Mannitol Starch Complex, Cellulose, Sorbitol, natural Raspberry flavor, Magnesium Stearate, Citric Acid, Sodium Bicarbonate, Polysaccharides, Silica, Stevia leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Innovative quality Since 1932

ActivMelt Instant dissolve

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 Daily

Directions: Use only as directed. Dissolve one ActivMelt micro tablet on or under the tongue daily.

Formula

Red Raspberry natural flavor

Discussion: KAL B-12 Methylcobalamin ActivMelt micro tablets, bursting with sweet, natural raspberry flavor, melt quickly in the mouth and are designed for optimal absorption in the body. Methylcobalamin, or Coenzyme B-12, is the biologically active form of Vitamin B-12, which is intended to provide nutritive support for normal, healthy red blood cell synthesis, nerve function and homocysteine levels.

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Directions: Use only as directed.

Storage

Store in a cool, dry place.

Formulation

Vegetarian.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B-12 Methylcobalamin 1000 mcg Red Raspberry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Other (inactive) ingredients: Mannitol Starch Complex, Cellulose, Sorbitol, Natural Raspberry flavor, Magnesium Stearate, Citric Acid, Sodium Bicarbonate, Polysaccharides, Silica, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL Drug Interactions

Want to check YOUR meds against B-12 Methylcobalamin 1000 mcg Red Raspberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in B-12 Methylcobalamin 1000 mcg Red Raspberry interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in B-12 Methylcobalamin 1000 mcg Red Raspberry interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in B-12 Methylcobalamin 1000 mcg Red Raspberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B-12 Methylcobalamin 1000 mcg Red Raspberry, from the product label.

KAL

See all KAL products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL: Common Questions

Does B-12 Methylcobalamin 1000 mcg Red Raspberry by KAL interact with any medications?
Yes. Based on its ingredients, B-12 Methylcobalamin 1000 mcg Red Raspberry has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B-12 Methylcobalamin 1000 mcg Red Raspberry contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this B12 supplement work if I take metformin for my diabetes?
Metformin can lower your B12 levels over time, so supplementing may help. But the two can interact slightly — metformin makes it harder for your body to absorb B12. Your doctor can check your B12 levels and advise whether you should take them together and, if so, how to space them for best absorption.
Is this safe to take while I'm pregnant or breastfeeding?
Yes. B12 is actually needed during both pregnancy and breastfeeding and is considered safe at recommended doses. Follow your provider's advice on how much you need.
What's methylcobalamin, and why is it in this product instead of regular B12?
Methylcobalamin is a natural, active form of B12 that your body can use right away. It's considered just as effective as other B12 forms and may be easier for some people to absorb, but the facts here don't compare it directly to other types.
Can I take too much B12 from this tablet?
No. B12 is very safe at high doses because your body doesn't store excess — it removes what you don't need through urine. There's no established upper limit.
Will this help my canker sores or nerve pain?
For canker sores and postherpetic neuralgia — nerve pain after shingles — B12 shows promise but the evidence isn't strong yet. It's possibly effective, so it may help some people, but talk to your doctor about whether it's worth trying for your specific situation.
Does this tablet have a lot of fillers in it?
It does contain inactive ingredients like mannitol, starch, cellulose, sorbitol, and magnesium stearate to hold the tablet together and flavor it. If you're sensitive to any of those, check the full list on the label before you buy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B-12 Methylcobalamin 1000 mcg Red Raspberry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B-12 Methylcobalamin 1000 mcg Red Raspberry label
Go deeper

The Full Monographs Behind B-12 Methylcobalamin 1000 mcg Red Raspberry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

B-12 Methylcobalamin 1000 mcg Red Raspberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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