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Dietary supplement

B-12 Methylcobalamin Lozenges Ingredients & Drug Interactions

by Patient One 1 MediNutritionals

B-12 Methylcobalamin Lozenges label
See full label image
Lozenge Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B-12 Methylcobalamin Lozenges against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

B-12 Methylcobalamin Lozenges is a dietary supplement by Patient One 1 MediNutritionals with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals

Ask about any prescription or over-the-counter medication and we check it for interactions with B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: vitamin B12 (in the form methylcobalamin). B12 is an essential vitamin your body needs for nerve function, red blood cell formation, and DNA synthesis.

The lozenges also contain inactive ingredients—Pearlitol, natural cherry flavor, leucine, and stevia rebaudiana extract—which serve as sweeteners, binders, and flavorings.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Vitamin B12 supplementation and nutritional support.
  • We looked for evidence on: Vitamin B12 deficiency, Fatigue, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Hyperhomocysteinemia — and 4 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.

Vitamin B12 is effective for treating Imerslund-Grasbeck disease (a rare genetic condition affecting B12 absorption) and for correcting B12 deficiency itself. It's also likely effective for cyanide poisoning.

For canker sores and postherpetic neuralgia (pain after shingles), the evidence is possibly effective—meaning it shows promise but isn't conclusive.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally very well tolerated. Your body excretes excess B12 in urine, so there's no established upper limit of how much you can take.

In rare cases, allergic reactions such as rash, itching, or hives have been reported; in one case, someone with a cobalt allergy developed contact dermatitis from oral methylcobalamin. Very rarely, correcting severe B12 deficiency has been linked to a dangerous drop in potassium (hypokalemia), though this is uncommon.

B12 is considered safe during pregnancy and breastfeeding at recommended amounts—in fact, it's needed at both times.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication to double-check is metformin (Glucophage), which can lower B12 levels with long-term use—a Minor interaction. No other interactions are documented in our data for vitamin B12 with medications we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This is a straightforward B12 supplement for people with deficiency or certain genetic conditions. If you take metformin, mention this lozenges to your pharmacist so they can monitor your B12 levels.

B12 is well tolerated, but if you have a cobalt allergy, check with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B-12 Methylcobalamin Lozenges, straight from the product label.

Brand Patient One 1 MediNutritionals
Barcode (UPC) 853959004045
Net contents 120 Lozenge(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 249160
Product type Vitamin
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
120
UPC/BARCODE
853959004045
IngredientAmount% DV
Vitamin B122000 mcg83333%

Other ingredients: Pearlitol, natural Cherry flavor, Leucine, Stevia rebaudiana extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegetarian

Gluten Free Non-GMO Free of: milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. Free of ingredients derived from GMOs.

Suggested/Recommended/Usage/Directions

Suggested Use: Allow 1 lozenge to dissolve in mouth daily as a dietary supplement, or as directed by your health practitioner.

Storage

Store in a cool, dry place.

Precautions

Caution: If you are pregnant, nursing or taking any medications, consult health practitioner before use.

Discontinue use and consult your health practitioner if any adverse reactions occur.

Keep out of reach of children.

Use only if safety seal is intact.

FDA Statement of Identity

Dietary Supplement

General Statements

Exclusive Professional Formulas

BPA free

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B-12 Methylcobalamin Lozenges label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container120 Amounts shown are per serving.

Vitamin B12

Interacts with
20 drugs
2000 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Other (inactive) ingredients: Pearlitol, Natural Cherry flavor, Leucine, Stevia rebaudiana extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals Drug Interactions

Want to check YOUR meds against B-12 Methylcobalamin Lozenges?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in B-12 Methylcobalamin Lozenges interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in B-12 Methylcobalamin Lozenges interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in B-12 Methylcobalamin Lozenges with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B-12 Methylcobalamin Lozenges, from the product label.

Patient One 1 MediNutritionals

See all Patient One 1 MediNutritionals products
Name
MediNutritionals Research LLC
City
Hauppage
State
NY
ZipCode
11788
Phone Number
(631) 390-9669
Web Address
patientoneformulas.com
Pharmacist Counseling Corner

B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals: Common Questions

Does B-12 Methylcobalamin Lozenges by Patient One 1 MediNutritionals interact with any medications?
Yes. Based on its ingredients, B-12 Methylcobalamin Lozenges has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B-12 Methylcobalamin Lozenges contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this B12 lozenges interfere with my medications?
One documented interaction exists: if you take metformin for diabetes, it can lower your B12 levels over time, though this is rated Minor. No other interactions are documented for the medications we checked. Use the search tool on this page to look up your specific drugs.
Is B12 safe to take if I'm pregnant or breastfeeding?
Yes. B12 is considered safe at normal recommended amounts during both pregnancy and breastfeeding, and in fact your body needs it at both times. Follow your provider's advice on dosing.
What is methylcobalamin, and why this form of B12?
Methylcobalamin is one active form of vitamin B12. It's the form found naturally in foods and is readily used by your body for nerve function, energy, and DNA synthesis. The lozenges dissolve in your mouth, which can help with absorption.
What does B12 do in the body?
B12 is essential for making red blood cells, supporting nerve function, and synthesizing DNA. It's particularly important if you have a B12 deficiency or certain genetic conditions that prevent normal absorption.
Are there any common side effects?
B12 is generally well tolerated when taken by mouth. Allergic reactions like rash or itching are rare, and very rarely, correcting severe deficiency has been linked to a dangerous drop in potassium. If you develop a rash or unusual symptoms, tell your pharmacist.
Does this product contain any fillers or inactive ingredients I should know about?
Yes, the lozenges contain Pearlitol, natural cherry flavor, leucine, and stevia rebaudiana extract as inactive ingredients—these are sweeteners and binders that help form the lozenge.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B-12 Methylcobalamin Lozenges label
Go deeper

The Full Monographs Behind B-12 Methylcobalamin Lozenges’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

B-12 Methylcobalamin Lozenges's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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