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Dietary supplement

B-2 100 mg Ingredients & Drug Interactions

by Nature's Bounty

B-2 100 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B-2 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B-2 100 mg is a dietary supplement by Nature's Bounty with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B-2 100 mg by Nature's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with B-2 100 mg by Nature's Bounty — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B-2 100 mg by Nature's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: riboflavin (vitamin B2) at 100 mg per tablet. Riboflavin is a B vitamin your body uses for energy production and cell health.

The tablet also contains inactive ingredients — dicalcium phosphate and vegetable cellulose — which are fillers and binders that help hold the tablet together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: B vitamins support energy metabolism.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for riboflavin in our records. If you're considering this product for a specific health reason, talk with your doctor or pharmacist about whether the evidence supports its use for your situation.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is generally well tolerated. The most common side effects are dose-related nausea and bright yellow urine — both harmless and temporary.

Rarely, people report diarrhea at higher doses. Because excess riboflavin is cleared through your urine, it's considered very safe at typical amounts.

Riboflavin is needed during pregnancy and while breastfeeding, and it's generally safe at recommended doses. If you're pregnant, nursing, or thinking about using a higher-dose supplement, check with your doctor or pharmacist first for personalized advice.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take tetracycline antibiotics (a class used for bacterial infections), check with your doctor or pharmacist before starting this product — riboflavin may reduce their effectiveness, though this hasn't been confirmed in humans.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward B2 supplement, well tolerated and useful if you need riboflavin replacement. The main thing to watch is if you take tetracycline antibiotics — confirm with your own doctor or pharmacist before combining them.

If you're pregnant or breastfeeding, talk it over with your provider before starting any supplement dose.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B-2 100 mg, straight from the product label.

Brand Nature's Bounty
Barcode (UPC) 074312006401
Net contents 100 Coated Tablet(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 74272
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B-2 100 mg by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
074312006401
IngredientAmount% DV
Riboflavin100 mg7692%

Other ingredients: Dicalcium Phosphate, Vegetable Cellulose, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nearly 50 years of trusted quality

At Nature’s Bounty, we are committed to your health. For nearly 50 years we have been making trusted products, backed by science, and made with only the purest ingredients...guaranteed. So you can get the most out of life every day.

Coated tablets Guaranteed quality Laboratory tested

B Vitamins support energy by converting food into energy.

Nutrition questions or comments? Call 1-800-433-2990 Mon. - Sat. 9 AM - 7 PM ET Join our loyalty program at NaturesBountyRewards.com

Aids in the conversion of food into energy

Energy health

Made in the USA with select ingredients from around the world

Formulation

Non-GMO, no artificial color, no artificial flavor, no artificial sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. sodium free.

Suitable for vegetarians.

General

Prod. No. 640 11E B640

Formula

Riboflavin

FDA Statement of Identity

Vitamin Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2017 Nature's Bounty, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B-2 100 mg by Nature's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B-2 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B-2 100 mg by Nature's Bounty

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
100 mg per serving Form: Vitamin B2

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Vegetable Cellulose, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

B-2 100 mg by Nature's Bounty Drug Interactions

Want to check YOUR meds against B-2 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in B-2 100 mg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in B-2 100 mg interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in B-2 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B-2 100 mg, from the product label.

Nature's Bounty

See all Nature's Bounty products
Name
Nature's Bounty, Inc.
City
Bohemia
State
NY
ZipCode
11716
Phone Number
1-800-433-2990
Pharmacist Counseling Corner

B-2 100 mg by Nature's Bounty: Common Questions

Does B-2 100 mg by Nature's Bounty interact with any medications?
Yes. Based on its ingredients, B-2 100 mg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B-2 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this turn my urine bright yellow?
Yes, at higher doses riboflavin commonly causes bright yellow urine. It's harmless — just your body clearing excess B2 that it doesn't need. At the 100 mg dose in this product, it's a possible side effect.
Can I take this while pregnant?
Riboflavin is actually needed during pregnancy and is generally safe at normal recommended amounts. If you want to use this 100 mg supplement while pregnant, check with your doctor or pharmacist first to make sure the dose is right for you.
Is riboflavin the same as B2?
Yes — riboflavin is the chemical name for vitamin B2. They're the same thing.
What does riboflavin do in my body?
Riboflavin is a B vitamin that helps your body produce energy from food and supports cell health. Your body can't store much of it, so it needs to come from your diet or supplements.
Can I take too much of this?
Riboflavin is very safe — your body simply clears excess amounts in your urine, so true toxicity from too much is not a concern. That said, higher doses can cause nausea and yellow urine. Stick to the dose on the label unless your doctor tells you otherwise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B-2 100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B-2 100 mg label
Go deeper

The Full Monographs Behind B-2 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

B-2 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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