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Dietary supplement

Stevia Ingredients & Drug Interactions

by Nature's Bounty

Stevia label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stevia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stevia is a dietary supplement by Nature's Bounty with 2 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia extract, Inulin Fiber. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stevia by Nature's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Stevia by Nature's Bounty — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stevia by Nature's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend {Combination}” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains 2 active ingredients. Inulin fiber is a soluble fiber that may help with blood sugar control, constipation, and weight management.

Stevia extract is a sweetening ingredient derived from the stevia plant; the product also lists stevia extract among its inactive (non-functional) ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Natural sweetener with prebiotic fiber support.
  • We looked for evidence on: Constipation, Diabetes, Hypercholesterolemia, Hypertension, Impaired glucose tolerance (prediabetes), Obesity — and 3 related terms.
  • The strongest evidence on file: Inulin is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Inulin is rated "Possibly Effective" for Diabetes, Obesity.
  • Also on file: Stevia is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hypertension, Obesity.

For inulin fiber, the evidence suggests it may be effective for obesity, constipation, and diabetes management—though the research on its actual blood-sugar-lowering ability is mixed. For stevia extract, the evidence on diabetes, high blood pressure, and obesity isn't established enough to rate in our data.

The safety profile for high-dose supplement use of either ingredient is not well studied.

The evidence, ingredient by ingredient Inulin Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inulin fiber is generally well tolerated in food amounts but commonly causes gas, bloating, diarrhea, constipation, and stomach cramps—especially at doses above 30 grams. Anaphylaxis (a severe allergic reaction) is rare but has occurred with foods high in inulin.

Inulin fiber is likely safe in pregnancy and lactation. Stevia extract and its components appear well tolerated, with most side effects (headache, dizziness, numbness, muscle pain, nausea, bloating) being mild and often resolving within the first week.

Allergic reactions are rare. The safety of whole-leaf stevia or high-dose supplement forms is not well studied, so caution is warranted.

Side effects, ingredient by ingredient Inulin Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Stevia, Inulin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting if you take lithium—stevia extract may raise lithium levels (Moderate severity). Also double-check if you're on blood pressure medications or diabetes drugs; both have Minor interactions with ingredients in this product.

If you take any other prescription medications, run them through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take lithium, blood pressure medication, or diabetes medication, check this product with your pharmacist first—the interactions are documented and worth reviewing. Even if you don't take those drugs, use the medication checker below for any prescriptions you're on.

Expect some digestive side effects, especially gas and bloating, if you're new to inulin fiber.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stevia, straight from the product label.

Brand Nature's Bounty
Barcode (UPC) 074312193958
Net contents 100 Packet(s); 3.52 oz.; 100 g
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 4156
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stevia by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Gram(s)
Maximum serving Sizes:
0.5 Gram(s)
Servings per container
200
UPC/BARCODE
074312193958
IngredientAmount% DV
Inulin Fiber0 NP--
Proprietary Blend {Combination}500 mg--
Stevia extract0 NP--

Other ingredients: Stevia extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, use 1/2 packet (0.5 g). Mixes instantly, add to your favorite food or beverage, hot or cold

Note: Due to the Fiber content of this product, pour liquid into a cup first, then pour product in and stir.

Precautions

Keep out of reach of children.

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Do not use if packet is torn or open.

Not intended for use by persons under the age of 18.

Storage

Store at room temperature.

Formula

All Natural Formula Made with STEVIA EXTRACT Add to your favorite food or beverage, hot or cold! - 0 Calories - 0 Preservatives - 0 Sugar - Low Glycemic Index

All Natural Sweet Herb WITH INULIN FIBER

Contains Prebiotic Inulin, a Natural Source of Fiber

General Statements

2.5 packets = the fiber of a slice of Whole Wheat Bread 3.5 packets = the fiber in one bowl of Oatmeal** **1 packet of instant oatmeal. Based on USDA nutrient database.

Great Tasting

If you’re living a healthy lifestyle, then you’ll absolutely want to add Stevia to your diet! It mixes easily into hot and cold beverages and is the perfect complement to your favorite recipes. The best part? You get a great-tasting addition to your foods and beverages for zero calories! Also known as “sweetleaf ” or “sweet herb”, our Stevia Extract contains no calories, sugar, preservatives or artificial flavors, and is 100% natural. Our Stevia also contains Prebiotic Inulin, a soluble fiber, an important component of a healthy diet.

Mixes Instantly

Scientifically Formulated Nutritional Support

General

Prod. No. 19395 02B B19394 AAA

Brand IP Statement(s)

(C)2011 Nature’s Bounty, Inc.

Nutrition Questions or Comments? Call NutraPhone(R) 1-800-433-2990 Mon.- Fri. 9 AM - 7 PM ET

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stevia by Nature's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stevia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stevia by Nature's Bounty

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 Gram(s) Dosage formOther (e.g. Tea Bag) Servings per container200 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend {Combination}

500 mg per serving

Other (inactive) ingredients: Stevia extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stevia by Nature's Bounty Drug Interactions

Want to check YOUR meds against Stevia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia extract 259
Inulin Fiber 86

Individual Drug Interactions

The ingredients in Stevia interact with 259 drugs. Click any drug to see the details.

2 of the 2 ingredients in Stevia interact with drugs. Each result below shows which ingredient is responsible. Stevia extract Inulin Fiber

Each ingredient & the kinds of drugs it affects

For each ingredient in Stevia with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia extract full monograph & interactions

Inulin Fiber1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin Fiber full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stevia, from the product label.

Nature's Bounty

See all Nature's Bounty products
Web Address
www.NaturesBounty.com
Pharmacist Counseling Corner

Stevia by Nature's Bounty: Common Questions

Does Stevia by Nature's Bounty interact with any medications?
Yes. Based on its ingredients, Stevia has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stevia contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my blood sugar?
Inulin fiber may help with diabetes management based on some research, but stevia extract doesn't have enough solid evidence for us to say. Either way, if you're on diabetes medication, talk to your pharmacist first—this product could theoretically increase your low blood sugar risk.
Is this safe if I'm pregnant?
Inulin fiber is likely safe in pregnancy. The product facts don't include safety information for stevia extract in pregnancy and lactation, so we don't have data on that. Talk to your doctor or pharmacist for personalized advice.
What side effects should I expect?
Gas, bloating, and digestive upset are common, especially if you take more than 30 grams of inulin. With stevia, headache, dizziness, nausea, and muscle pain are possible but usually mild and often go away after the first week.
Why does the product have stevia extract listed twice?
Stevia extract appears once as an active ingredient and once in the inactive ingredients list—sometimes an ingredient serves both purposes in the formulation.
Can I use this as a sweetener instead of sugar?
The product facts don't describe it as intended for sweetening use. The evidence on its effectiveness for obesity or weight management isn't established in our data, so check with your pharmacist about how it fits your goals.
Is this safe to take long-term?
Inulin in food amounts is well tolerated, but long-term safety at high supplement doses hasn't been well studied. The same goes for stevia extract. If you're planning to use it regularly, talk to your pharmacist about what the research supports for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stevia label
Go deeper

The Full Monographs Behind Stevia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Stevia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
  11. Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23 PubMed
  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
  13. Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. PubMed
  14. Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. PubMed
  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed

See these in context on the Inulin monograph →

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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