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Dietary supplement

Sure Stevia Natural Vanilla Ingredients & Drug Interactions

by KAL

Sure Stevia Natural Vanilla label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sure Stevia Natural Vanilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sure Stevia Natural Vanilla is a dietary supplement by KAL with 1 active ingredient. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sure Stevia Natural Vanilla by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with Sure Stevia Natural Vanilla by KAL — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sure Stevia Natural Vanilla by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: stevia leaf extract, a no-calorie sweetener derived from the stevia plant. It's mixed with water, apple cider vinegar, natural vanilla flavor, and citric acid to create a liquid sweetener you can add to drinks or food.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Stevia product and its label doesn't state a use — see Stevia's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for stevia's effectiveness is not established in the data we hold. The product facts show insufficient reliable evidence to rate stevia for diabetes control, high blood pressure, or weight loss.

Some preliminary research hints that stevia may lower blood sugar levels, but the findings are mixed and not robust enough to make a claim.

The evidence, ingredient by ingredient Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Stevia leaf extract is generally well tolerated when used orally. The most common minor side effects — bloating, dizziness, headache, muscle pain, nausea, and numbness — tend to fade after the first week.

Allergic reactions are rare. The safety notes flag that purified stevia in food amounts is considered safe, but high-dose supplements like this one lack solid long-term safety data, so use caution.

Side effects, ingredient by ingredient Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, look up any lithium you're taking — stevia may raise its levels. Also double-check blood pressure medications and diabetes drugs.

No interactions are documented for the other inactive ingredients we hold data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

KAL Sure Stevia Natural Vanilla is a liquid stevia sweetener for people looking for a no-calorie sugar replacement. If you take lithium, blood pressure meds, or diabetes meds, talk to your pharmacist before using it.

For everyone else, check your medications on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sure Stevia Natural Vanilla, straight from the product label.

Brand KAL
Barcode (UPC) 021245642954
Net contents 1.8 Fluid Ounce(s); 53.2 mL
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322946
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sure Stevia Natural Vanilla by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.15 mL
Maximum serving Sizes:
0.15 mL
Servings per container
354
UPC/BARCODE
021245642954
IngredientAmount% DV
Stevia Leaf Extract37.5 mg--

Other ingredients: Water, Apple Cider Vinegar, Vanilla Flavor, Natural, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Great taste

Also available in powder form.

Brand IP Statement(s)

Trust KAL Quality Since 1932

Formula

Sure Stevia Extract

Zero-calorie sweetener Vanilla Natural Flavor

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Use daily by adding to your favorite food or beverage. Shake before using. Use only as directed.

Storage

Store in a cool, dry place.

Formulation

Discussion: Outstanding flavor with no bitter aftertaste and NO calories.

Discussion: Outstanding flavor with no bitter aftertaste and NO calories.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sure Stevia Natural Vanilla by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sure Stevia Natural Vanilla label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sure Stevia Natural Vanilla by KAL

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.15 mL Dosage formLiquid Servings per container354 Amounts shown are per serving.

Stevia Leaf Extract

Interacts with
259 drugs
37.5 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia Leaf Extract monograph & interactions

Other (inactive) ingredients: Water, Apple Cider Vinegar, Vanilla Flavor, Natural, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sure Stevia Natural Vanilla by KAL Drug Interactions

Want to check YOUR meds against Sure Stevia Natural Vanilla?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia Leaf Extract 259

Individual Drug Interactions

The ingredients in Sure Stevia Natural Vanilla interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sure Stevia Natural Vanilla interact with drugs. Each result below shows which ingredient is responsible. Stevia Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sure Stevia Natural Vanilla with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia Leaf Extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sure Stevia Natural Vanilla, from the product label.

KAL

See all KAL products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Sure Stevia Natural Vanilla by KAL: Common Questions

Does Sure Stevia Natural Vanilla by KAL interact with any medications?
Yes. Based on its ingredients, Sure Stevia Natural Vanilla has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sure Stevia Natural Vanilla contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is stevia safe to use if I don't take any medications?
For most people without medications, the safety data shows stevia leaf extract is generally well tolerated. Keep in mind that high-dose supplements like this one haven't been studied as thoroughly as stevia in everyday food amounts, so it's smart to use it as directed and watch for any unusual symptoms like dizziness or headache.
What are the common side effects of stevia?
The most common ones are bloating, dizziness, headache, muscle pain, nausea, and numbness. The good news is these tend to clear up after the first week. Allergic reactions are rare but possible.
Does stevia actually help with weight loss or blood sugar control?
The evidence isn't strong enough to make that claim based on the data we hold. Some early research suggests stevia *might* help lower blood sugar, but the findings are mixed and not reliable enough to say it works for those purposes.
Can I use this product while breastfeeding or pregnant?
The safety data on file doesn't cover pregnancy or breastfeeding, so there isn't enough information to know either way. Talk with your doctor or pharmacist for personalized advice based on your situation.
What makes KAL Sure Stevia different from other stevia products?
This specific product is a liquid form flavored with natural vanilla. The active ingredient — stevia leaf extract — is the same across most stevia products, but the base, flavor, and form differ by brand.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sure Stevia Natural Vanilla is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sure Stevia Natural Vanilla label
Go deeper

The Full Monographs Behind Sure Stevia Natural Vanilla’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Sure Stevia Natural Vanilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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