Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Sweet 'n Natural Stevia Leaf Extract Ingredients & Drug Interactions

by Superior Source

Sweet 'n Natural Stevia Leaf Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sweet 'n Natural Stevia Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sweet 'n Natural Stevia Leaf Extract is a dietary supplement by Superior Source with 2 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sweet 'n Natural Stevia Leaf Extract by Superior Source

Ask about any prescription or over-the-counter medication and we check it for interactions with Sweet 'n Natural Stevia Leaf Extract by Superior Source — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sweet 'n Natural Stevia Leaf Extract by Superior Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: stevia leaf extract, a sweetener derived from the stevia plant. The inactive ingredient is lactose, a common filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Stevia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Natural sweetener for low-sugar dietary alternatives.
  • We looked for evidence on: Diabetes, Obesity, Hypertension, Blood glucose control, Weight management.
  • The closest evidence on file: Stevia is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Stevia is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Obesity.

The evidence for stevia's effectiveness is limited. For diabetes, high blood pressure, and weight management—the main claims made about stevia—the data we hold shows insufficient reliable evidence to rate whether it actually works.

One small clinical trial found that a single 1000 mg dose reduced blood sugar spikes in people with type 2 diabetes when taken with a meal, but other research hasn't confirmed the same effect, so we can't say yet whether it's truly effective for blood sugar control.

The evidence, ingredient by ingredient Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Purified stevia in typical food amounts is generally recognized as safe. However, because this is a supplement dose (not food amounts) and whole-leaf stevia hasn't been well studied at high doses, use caution.

Most people who take stevia tolerate it well, though some report minor side effects like bloating, dizziness, headache, muscle aches, nausea, or numbness—most of these ease up after the first week. Allergic reactions are rare but have been reported.

There isn't enough safety data on file for pregnancy or breastfeeding.

Side effects, ingredient by ingredient Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before taking this product if you use lithium (mood stabilizer)—stevia may raise its levels. You should also double-check if you take blood pressure medications or diabetes drugs, where stevia might increase the effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking for a stevia supplement and don't take lithium, blood pressure medication, or diabetes medication, this product is generally well tolerated. If you do take any of those, check with your pharmacist first.

Talk to us before starting any new supplement, especially if you're on prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sweet 'n Natural Stevia Leaf Extract, straight from the product label.

Brand Superior Source
Barcode (UPC) 076635400201
Net contents 9.73 oz.; 276 Gram(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 212803
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sweet 'n Natural Stevia Leaf Extract by Superior Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.876 Gram(s)
Maximum serving Sizes:
0.876 Gram(s)
Servings per container
315
UPC/BARCODE
076635400201
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Sugar1 Gram(s)--
Stevia leaf extract22.8 mg--

Other ingredients: Lactose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Fresh look Same great taste!

Compare and decide: Herbal Aspartame free Saccharin free Sucralose free Sweet 'n Natural Yes Yes Yes Yes Equal No No Yes Yes Sweet 'n Low No Yes No Yes NutraSweet No No Yes Yes Splenda No Yes Yes No

For information & recipe ideas visit www.cvc4health.com

Formulation

Zero calorie powder

More recent medical research has shown promise in treating obesity and hypertension. Stevia has a negligible effect on blood glucose, even enhancing glucose tolerance; therefore, it is attractive as a natural sweetener to diabetics and others on carbohydrate-controlled diets.

Sweet ‘n Natural is Calorie free, Saccharin free, Aspartame free, and Sucralose free.

FDA Statement of Identity

Dietary Supplement

Formula

Stevia is a genus of about 240 species of herbs and shrubs in the sunflower family (Asteraceae), native to subtropical and tropical regions from western North America to South America. The species Stevia rebaudiana, commonly known as sweetleaf or Sugarleaf, or simply stevia, is widely grown for its sweet leaves. As a sweetener and sugar substitute, stevia’s taste has a slower onset and longer duration than that of sugar.

With its extracts having up to 300 times the sweetness of sugar, stevia has garnered attention with the rise in demand for low-carbohydrate, low sugar food alternatives. In a few countries, it has been available as a sweetener for decades or centuries; for example; stevia is widely used as a sweetener in Japan where it has been available for decades.

Suggested/Recommended/Usage/Directions

Directions: As an herbal dietary supplement, take 1/3 teaspoon into food or stir into beverages.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Equal is a registered trademark of Merisant Company, Chicago, IL Sweet’ n Low is a registered trademark of Cumberland Packing Corp., Brooklyn, NY NutraSweet is a registered trademark of NutraSweet Company, Chicago, IL Splenda is a registered trademark of McNeil-PPC. Inc., Fort Washington, PA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sweet 'n Natural Stevia Leaf Extract by Superior Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sweet 'n Natural Stevia Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sweet 'n Natural Stevia Leaf Extract by Superior Source

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.876 Gram(s) Dosage formPowder Servings per container315 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Stevia leaf extract

Interacts with
259 drugs
22.8 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Other (inactive) ingredients: Lactose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sweet 'n Natural Stevia Leaf Extract by Superior Source Drug Interactions

Want to check YOUR meds against Sweet 'n Natural Stevia Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia leaf extract 259

Individual Drug Interactions

The ingredients in Sweet 'n Natural Stevia Leaf Extract interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in Sweet 'n Natural Stevia Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. Stevia leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sweet 'n Natural Stevia Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sweet 'n Natural Stevia Leaf Extract, from the product label.

Superior Source

See all Superior Source products
Name
Superior Source Products
City
Los Angeles
State
CA
ZipCode
90058
Phone Number
(800) 421-6175
Pharmacist Counseling Corner

Sweet 'n Natural Stevia Leaf Extract by Superior Source: Common Questions

Does Sweet 'n Natural Stevia Leaf Extract by Superior Source interact with any medications?
Yes. Based on its ingredients, Sweet 'n Natural Stevia Leaf Extract has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sweet 'n Natural Stevia Leaf Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I notice?
Most people tolerate stevia well. Some report bloating, dizziness, headache, muscle aches, nausea, or numbness early on—these usually fade after the first week. Allergic reactions are rare.
Will stevia actually help my blood sugar or weight?
We don't have reliable evidence yet that it works for diabetes, high blood pressure, or weight loss. One small trial showed it might help with blood sugar spikes after a meal, but other research hasn't confirmed that, so we can't say for sure.
Is this safe as a sweetener?
Purified stevia in food amounts is considered safe. This supplement dose is different—it hasn't been studied much at high doses, so use caution and talk to your pharmacist about whether it's right for you.
Can I take this while pregnant or breastfeeding?
We don't have safety data on file for pregnancy or breastfeeding. Talk with your doctor or pharmacist to decide what's right for you.
What's in this powder besides the active ingredient?
The only inactive ingredient listed is lactose. If you're lactose intolerant or sensitive to it, let us know and we can help you find another option.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sweet 'n Natural Stevia Leaf Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sweet 'n Natural Stevia Leaf Extract label
Go deeper

The Full Monographs Behind Sweet 'n Natural Stevia Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Sweet 'n Natural Stevia Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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