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Dietary supplement

Xylitol Plus Ingredients & Drug Interactions

by NOW

Xylitol Plus label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Xylitol Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Xylitol Plus is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Xylitol Plus by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Xylitol Plus by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Xylitol Plus by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Xylitol Plus is a single-ingredient product: stevia extract, a no-calorie sweetener derived from the stevia plant. The powder also contains silica as an inactive ingredient (a flow agent to keep it from clumping).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Stevia product and its label doesn't state a use — see Stevia's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for stevia's effectiveness isn't well established in the data we hold. For diabetes, high blood pressure, and weight loss, the ratings are all insufficient reliable evidence to rate — meaning there isn't enough solid clinical trial data to say whether it actually works for those purposes.

It's used as a sweetener, but we don't have effectiveness data for that claim either.

The evidence, ingredient by ingredient Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Purified stevia sweeteners at typical food amounts are generally recognized as safe. However, whole-leaf stevia or supplement-dose products (like this powder) aren't as well studied, so use caution with higher amounts.

When taken by mouth, stevia and its components are usually well tolerated, though some people report minor side effects like bloating, dizziness, headache, muscle aches, nausea, and numbness — most of these resolve after the first week. Rare allergic reactions have been reported.

We don't have pregnancy or breastfeeding safety data on file for this ingredient, so talk with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, check with your pharmacist before using this product — stevia may raise lithium levels (Moderate severity). Also double-check if you're on blood pressure medications or diabetes drugs, as stevia may increase the effects of both (Minor severity for each).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Xylitol Plus is a stevia-based sweetener. If you take lithium, blood pressure medications, or diabetes drugs, check with your pharmacist or doctor first — stevia has documented interactions with all three.

For everyone else, it's generally well tolerated, though we don't have strong evidence it works for blood sugar control or weight loss.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Xylitol Plus, straight from the product label.

Brand NOW
Barcode (UPC) 733739069887
Net contents 75 Packet(s); 4.76 oz.; 135 Gram(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28627
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Xylitol Plus by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.8 Gram(s)
Maximum serving Sizes:
1.8 Gram(s)
Servings per container
75
UPC/BARCODE
733739069887
IngredientAmount% DV
Calories2.3 {Calories}--
Total Carbohydrates1.76 Gram(s)1%
Stevia extract45 mg--
Sugar Alcohol1.72 Gram(s)--

Other ingredients: Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Diarrhea may occur with excessive consumption. If this happens, reduce intake or discontinue use.

Note: Xylitol is safe for people, but harmful to dogs. Do not feed to pets.

General Statements

This carton is made from 100% Recyclable Material. CODE 6988 V6

Not labeled for individual sale

{Packet} NET WT.0.06 oz. (1.8 g)

Please Recycle.

HISTORY OF Xylitol Xylitol is a sugar alcohol that is naturally present in small amounts in various fruits and vegetables. The Finnish name for Xylitol is “koivusokeri”, or birch sugar, a reference to the extraction of Xylitol from birch bark. Considerable amounts of Xylitol are formed in the body every day as a result of normal metabolic processes. Although it is classified as a carbohydrate, this sweet crystalline substance is slowly absorbed from the digestive tract and does not cause rapid rises in blood glucose. In addition, the caloric impact of Xylitol is typically about 40% lower than other carbohydrates, making it a healthy addition to any diet. Discovered simultaneously by French and German scientists in 1891, Xylitol has been safely used since the 1970’s as an ingredient in gums and candies due to its unique and clinically proven dental benefits. Xylitol is a sugar alcohol that cannot be utilized by bacteria in the mouth. More recent research in laboratory animals has also shown that Xylitol may support healthy bones.* The xylitol in this product is derived from a Non-GMO corn source.

Since 1968 NOW has been committed to providing high quality, affordable natural foods, vitamins and personal care products. No compromises, no added costs, no unnecessary frills. In addition to our Xylitol Plus with Stevia, NOW offers Xylitol and Stevia separately for your convenience, in a variety of forms. We continue to provide certified organic or natural foods, grains, flours and seeds through health food stores. As a family owned and operated business, we offer the health-conscious consumer three generations of honesty, quality, purity and commitment.

Nutrition for Optimal Wellness.

Then God said, “I give you every seed-bearing plant on the face of the whole earth and every tree that has fruit with seed in it. They will be yours for food.” Gen. 1:29

- Low Glycemic Index

- Superior Taste - 40% Less Calories Than Sugar - Supports Dental Health* - Supports Healthy Bones*

Made in the U.S.A.

Stevia Extract is a dietary ingredient.

Made from 100% Recyclable Material.

FDA Disclaimer Statement

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

- With Stevia Extract

Formulation

- Aspartame-Free

Contains no salt, yeast, wheat, gluten, soy, milk, egg, shellfish, preservatives, artificial colors, artificial flavors, or artificial sweeteners.

Seals/Symbols

GMP QUALITY ASSURED

now(R)

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, take one packet as desired.

Storage

Store in a cool, dry place.

General

CODE 6988 V5

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Xylitol Plus by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Xylitol Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Xylitol Plus by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.8 Gram(s) Dosage formPowder Servings per container75 Amounts shown are per serving.

Stevia extract

Interacts with
259 drugs
45 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia extract monograph & interactions

Other (inactive) ingredients: Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Xylitol Plus by NOW Drug Interactions

Want to check YOUR meds against Xylitol Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia extract 259

Individual Drug Interactions

The ingredients in Xylitol Plus interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Xylitol Plus interact with drugs. Each result below shows which ingredient is responsible. Stevia extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Xylitol Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Xylitol Plus, from the product label.

NOW

See all NOW products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.nowfoods.com
Pharmacist Counseling Corner

Xylitol Plus by NOW: Common Questions

Does Xylitol Plus by NOW interact with any medications?
Yes. Based on its ingredients, Xylitol Plus has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Xylitol Plus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Xylitol Plus lower my blood sugar?
One small clinical study found that stevia extract may reduce blood glucose spikes after eating, but other research hasn't confirmed this effect. The evidence isn't strong enough to rate it as effective, so we can't say whether it will work for you.
Is this safe to use while pregnant or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for stevia supplements. Talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
What side effects might I notice?
The most common are bloating, dizziness, headache, muscle aches, nausea, and numbness. These are usually minor and tend to resolve after the first week. Allergic reactions are rare but possible.
Can I use this in place of sugar?
Yes — stevia extract is a no-calorie sweetener and that's its primary use. At typical food amounts, purified stevia is generally recognized as safe.
Does the powder contain any fillers?
It contains silica, an inactive ingredient used to prevent clumping. The stevia extract itself is the active ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Xylitol Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Xylitol Plus label
Go deeper

The Full Monographs Behind Xylitol Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Xylitol Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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