Baby Protectis Drops Immune Active Ingredients & Drug Interactions
by BioGaia
What is this page for?
First and foremost: checking Baby Protectis Drops Immune Active against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Baby Protectis Drops Immune Active is a dietary supplement by BioGaia with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Baby Protectis Drops Immune Active by BioGaia
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Baby Protectis Drops Immune Active by BioGaia
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Baby Protectis Drops Immune Active contains 2 active ingredients: vitamin D and Protectis. Vitamin D is a fat-soluble vitamin essential for calcium absorption, bone health, and immune function.
The product also includes two inactive ingredients — sunflower oil and vitamin E — which help deliver and preserve the active components. We hold no data on what Protectis is or does.
Does it work?
Moderate evidence
Vitamin D in this product is effective for treating rickets, renal bone disease (renal osteodystrophy), softened bones (osteomalacia), and familial hypophosphatemia — conditions where the body cannot absorb or process calcium and phosphate properly. We have no effectiveness data on file for Protectis.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses. However, very high doses taken over time can cause vitamin D toxicity, marked by high blood calcium (hypercalcemia), which may lead to bone loss in adults and slowed growth in children.
Serious side effects are rare but can include kidney problems (azotemia) and anemia. Vitamin D is often used during pregnancy at recommended amounts, but only under your doctor's guidance.
The same goes for higher doses while breastfeeding — check with your doctor first. We have no safety data on file for Protectis.
Meds to double-check
Moderate interaction found
Before giving this product, check whether your child takes digoxin (Lanoxin) or other heart rhythm medications — vitamin D can raise blood calcium and increase arrhythmia risk. Also check for thiazide diuretics (water pills), verapamil (Calan), diltiazem (Cardizem), atorvastatin (Lipitor), or any topical vitamin D creams like calcipotriene (Dovonex).
These are moderate-severity interactions with vitamin D at high doses.
The bottom line
Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is designed for infants and may be right for you if your child has a condition affecting bone or calcium metabolism and your pediatrician recommends it. If your child takes any prescription medications — especially heart rhythm or cholesterol drugs — check them against the interaction checker on this page first.
Talk to your pediatrician or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Baby Protectis Drops Immune Active, straight from the product label.
| Brand | BioGaia |
|---|---|
| Barcode (UPC) | 602359460537 |
| Net contents | 5 Milliliter(s); 0.17 Fluid Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 311002 |
| Product type | Other Combinations |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Infants/Baby (0 - 1 Year), Gluten Free, Dairy Free, Children more than 1 but less than 4 |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Baby Protectis Drops Immune Active by BioGaia, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D | 15 mcg | 150%, 100% |
| Protectis | 0 NP | -- |
Other ingredients: Sunflower Oil, Vitamin E
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Gut & immune health Clinically proven
Probiotic baby care
Country of origin Sweden.
Non-GMO ingredients, no artificial colors, flavors, dairy, soy or gluten. Milk free Lactose free Gluten free
Formula
Probiotic drops 600 IU vitamin D3
Probiotic drops with vitamin D3 BioGaia Protectis BABY drops Immune Active is a dietary supplement containing the patented probiotic Limosilactobacillus reuteri Protectis (L. reuteri DSM 17938) and vitamin D3 that contributes to the normal function of the immune system. L. reuteri Protectis helps keep a natural balance in the gut and has been balance tested in more than 150 clinical trials and proven effective & safe for children.
0-36 months
FDA Statement of Identity
Probiotic Supplement
Suggested/Recommended/Usage/Directions
Use: Five (5) drops once daily.
The package contains a white desiccant device for prolongation of shelf-life.
Dosing Shake well for 10 seconds before each use to mix the probiotic with the oil. To dispense drops press the tube gently and give by spoon. 5x Use 5 drops daily.
Shake well
Precautions
Recommended dose should not be exceeded. Do not give directly from the tube into the mouth as this may reduce the quality of the product.
Not intended for use in premature infants.
It should not be consumed.
Keep out of reach of children.
To report a serious adverse event, call (888) 485-2135.
Storage
Storage: Store in a dry place, at room temperature. Opened tube should be used within 3 months.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
BioGaia Groundbreaking probiotics Driven by science
Registered trademark belongs to BioGaia AB. Protected by corresponding patents of US7,374,942, US8,785,183 and other issued and pending patent applications.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Baby Protectis Drops Immune Active by BioGaia label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Baby Protectis Drops Immune Active by BioGaia
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size5 Drop(s) Dosage formLiquid Servings per container25 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin D
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D monograph & interactionsProtectis
Other (inactive) ingredients: Sunflower Oil, Vitamin E. These complete the product’s ingredient list but are not active constituents.
Baby Protectis Drops Immune Active by BioGaia Drug Interactions
HelloPharmacist Interaction Report
Baby Protectis Drops Immune Active by BioGaia contains vitamin D, which does interact with a number of medications.
The most serious concern involves heart rhythm drugs: high-dose vitamin D can raise calcium levels in your blood (hypercalcemia), which increases the risk of dangerous irregular heartbeats if you're taking digoxin (Lanoxin). This is a moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Vitamin D also interacts moderately with several other drug types. Thiazide water pills can reduce how much calcium your kidneys excrete, raising your blood calcium further if you're also taking vitamin D.
High-dose vitamin D can also blunt the effect of verapamil (Calan) and diltiazem (Cardizem), two other heart rhythm medications, by raising calcium levels. It may reduce how well your body absorbs atorvastatin (Lipitor), a cholesterol drug, and it theoretically increases the activity of an enzyme (CYP3A4) that breaks down many medications — though this is a minor concern.
We also hold no interaction data for Protectis, the second active ingredient in this product, so we cannot tell you what it may or may not do with your medications.
Altogether, these interactions span 705 individual medications. If you take any prescription medication, especially heart or cholesterol drugs, run it through the checker below before giving this product to your child.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Baby Protectis Drops Immune Active?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Baby Protectis Drops Immune Active interact with 715 drugs. Click any drug to see the details.
1 of the 2 ingredients in Baby Protectis Drops Immune Active interact with drugs. Each result below shows which ingredient is responsible. Vitamin D
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Alginic Acid, Aluminum Hydroxide interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Amiloride, Hydrochlorothiazide interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Atenolol, Chlorthalidone interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D + Atorvastatin Calcium interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Benzthiazide interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCalcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D + Betamethasone Dipropionate, Calcipotriene interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bisoprolol, Hydrochlorothiazide interactionCalcipotrieneDovonex
How Calcipotriene interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCalcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D + Calcipotriene interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with Baby Protectis Drops Immune Active — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Chlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Baby Protectis Drops Immune Active with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for Baby Protectis Drops Immune Active, from the product label.
BioGaia
See all BioGaia products- Name
- BioGaia USA
- City
- St. Louis
- State
- MO
- ZipCode
- 63139
- Phone Number
- (877)776-0101
- Web Address
- BioGaiaUSA.com
Baby Protectis Drops Immune Active by BioGaia: Common Questions
Does Baby Protectis Drops Immune Active by BioGaia interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will vitamin D in this product hurt if my child takes a heart medication?
What are the signs my child is getting too much vitamin D?
Can I give this to my baby if I'm breastfeeding?
Is this product just vitamin D, or does it have other things in it?
Can vitamin D reduce how well my child's cholesterol medicine works?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Baby Protectis Drops Immune Active is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Baby Protectis Drops Immune Active’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Baby Protectis Drops Immune Active's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
- Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
- Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
- Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
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