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Dietary supplement

Be Courageous Ingredients & Drug Interactions

by Nature's Sunshine Flower Essence Formula

Be Courageous label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Be Courageous against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Be Courageous is a dietary supplement by Nature's Sunshine Flower Essence Formula with 3 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 871 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Be Courageous by Nature's Sunshine Flower Essence Formula

Ask about any prescription or over-the-counter medication and we check it for interactions with Be Courageous by Nature's Sunshine Flower Essence Formula — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Be Courageous by Nature's Sunshine Flower Essence Formula

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.
  • “Infusions of the Flowers of” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Be Courageous is a liquid blend of 9 ingredients, most of them flower essences. The active ingredients include organic vegetable glycerin (a naturally derived sweetener and humectant), infusions from penstemon, aspen bark, ceratostigma, blackberry leaf or root, scleranthus, mimulus, and red clover flower.

The product also contains purified water. There are no inactive fillers or binders listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: courage and confidence for occasional emotional stress.
  • We looked for evidence on: anxiety, stress, nervousness, emotional resilience.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Our data doesn't include effectiveness ratings for most of the flower essences in this blend — penstemon, ceratostigma, scleranthus, and mimulus aren't rated for any condition in the evidence we hold. Red clover has been studied for hair loss, menopausal symptoms, joint health, and bone health, but the evidence for all four is too thin to rate.

Glycerin, the other ingredient we have data for, is likely effective for constipation and possibly effective for certain skin conditions, but it's included here in a formula aimed at emotional wellness, not those uses.

The evidence, ingredient by ingredient Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Overall, the ingredients here that we have safety data for are generally well tolerated. Glycerin can cause bloating, nausea, dizziness, or diarrhea in larger doses, and red clover may cause muscle pain, nausea, or vaginal spotting in some people.

Aspen carries a bigger caution: it contains aspirin-like salicylates and should be avoided in pregnancy and while breastfeeding. Red clover is also best avoided during pregnancy because of its estrogen-like effects, and there isn't enough safety data to recommend it while nursing.

The other ingredients — penstemon, ceratostigma, scleranthus, and mimulus — have no safety data on file.

Side effects, ingredient by ingredient Glycerol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Aspen, Red Clover.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 872 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take aspirin or other salicylate pain relievers (Trilisate, Disalcid), estrogen-containing medications, tamoxifen, methotrexate, blood thinners or antiplatelet drugs, or medications that your liver breaks down via the CYP1A2, CYP2C9, CYP2C19, or CYP3A4 pathways, run those through the tool below before starting this product. Red clover accounts for the majority of these interactions; aspen is the ingredient behind the salicylate concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a flower essence blend that combines several botanicals with little to no established evidence for its intended use. If you're on aspirin, salicylate-based pain relievers, estrogen therapy, tamoxifen, methotrexate, or blood thinners, you'll want to check your specific medications against our tool before taking it.

If you're pregnant or nursing, talk with your doctor or pharmacist first — aspen and red clover carry specific cautions for both. For anyone else considering it, a conversation with your own healthcare provider about whether it fits your needs is still worthwhile.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Be Courageous, straight from the product label.

Brand Nature's Sunshine Flower Essence Formula
Barcode (UPC) 099904087866
Net contents 1.9 fl. Oz.; 57 mL
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 208616
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Be Courageous by Nature's Sunshine Flower Essence Formula, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
57
UPC/BARCODE
099904087866
IngredientAmount% DV
purified Water0 NP--
Proprietary Blend1000 mg--
organic Vegetable Glycerin0 NP--
Infusions of the Flowers of0 NP--
Penstemon newberryi0 NP--
Populus tremula0 NP--
Ceratostigma willmottianum0 NP--
Rubus armeniacus0 NP--
Scleranthus annuus0 NP--
Mimulus guttatus0 NP--
Trifolium pratense0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Flower Essence Formulas are liquid infusions using only organic ingredients and those derived from flowers grown in organic gardens and pristine wild habitats.

Formulation

Flower Essence Formulas are liquid infusions using only organic ingredients and those derived from flowers grown in organic gardens and pristine wild habitats.

General Statements

Developed for modern issues of occasional emotional and physical stress. Formulated for direct use.

Vented fear formula Natural flower essence formula that may assist with: Courage and self confidence Indecisiveness and uncertainty Occasional nervous tension Get well keep well Quality, service, integrity

010087860613

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

2013

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 10-15 drops under the tongue, then swallow, 4 times daily. Avoid any contact with dropper to eliminate product contamination.

Precautions

This bottle was sealed for your protection. Do not use if outer shrink band is missing or damaged.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Be Courageous by Nature's Sunshine Flower Essence Formula label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Be Courageous label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Be Courageous by Nature's Sunshine Flower Essence Formula

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container57 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1000 mg per serving
Interaction report

Be Courageous by Nature's Sunshine Flower Essence Formula Drug Interactions

Want to check YOUR meds against Be Courageous?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
871Drugs
83 Moderate 788 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Be Courageous interact with 871 drugs. Click any drug to see the details.

0 of the 3 ingredients in Be Courageous interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Be Courageous with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Be Courageous, from the product label.

Nature's Sunshine Flower Essence Formula

See all Nature's Sunshine Flower Essence Formula products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Be Courageous by Nature's Sunshine Flower Essence Formula: Common Questions

Does Be Courageous by Nature's Sunshine Flower Essence Formula interact with any medications?
Yes. Based on its ingredients, Be Courageous has a known interaction with 871 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Be Courageous contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
No. Two ingredients here — aspen and red clover — should be avoided in pregnancy because of their aspirin-like and estrogen-like effects, respectively. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
It's not recommended. Aspen and red clover both have safety cautions against use while nursing. The other ingredients lack enough safety data while breastfeeding. Check with your doctor or pharmacist about whether it's right for you.
What's glycerin doing in here?
Glycerin is a naturally derived sweetener and thickener that makes the liquid taste better and easier to work with. In larger medicinal doses it can cause digestive upset, but the amount in a flower essence formula is typically much smaller.
Does this product have any fillers?
No fillers or binders are listed in the inactive ingredients for this formula — it's just the active flower essences and glycerin in water.
Is there any evidence this helps with anxiety or emotional balance?
Our data doesn't hold effectiveness ratings for most of the flower essences in this blend, so we can't say what the research shows for those. The formulation suggests those are its intended uses, but you'd want to look at third-party reviews or talk with your provider about whether flower essences work for your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Be Courageous is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Be Courageous label
Go deeper

The Full Monographs Behind Be Courageous’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph →
Sources

Sources & How We Checked

Be Courageous's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Aspen 3 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics. 5th ed. New York, NY: Macmillan Publ. Co., Inc., 1975.
  3. Aalto-Korte K, Välimaa J, Henriks-Eckerman ML, Jolanki R. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Contact Dermatitis 2005;52(2):93-5.

See these in context on the Aspen monograph →

Blackberry 1 reference
  1. Antioxidants: In Depth — NIH NCCIH Source

See these in context on the Blackberry monograph →

Red Clover 24 references
  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
  16. Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
  17. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
  18. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  19. Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
  20. Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
  21. Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
  22. Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
  23. Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
  24. Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed

See these in context on the Red Clover monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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