Bee Propolis Ultimate Ingredients & Drug Interactions
by NaturaNectar
What is this page for?
First and foremost: checking Bee Propolis Ultimate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bee Propolis Ultimate is a dietary supplement by NaturaNectar with 6 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flav-B. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bee Propolis Ultimate by NaturaNectar
Ask about any prescription or over-the-counter medication and we check it for interactions with Bee Propolis Ultimate by NaturaNectar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Bee Propolis Ultimate by NaturaNectar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Bee Propolis Ultimate contains 6 active ingredients, all propolis extracts: Flav-B, Flav-R, Flav-G, PWE-RD, PWE-GD, and PWE-MD. These are bee-derived compounds that research suggests may help with mouth sores, cold sores, and blood sugar support.
The capsule also holds inactive ingredients: cellulose, magnesium stearate, and silicon dioxide — all common binders and flow agents.
Does it work?
Moderate evidence
The data shows propolis is possibly effective for oral mucositis (mouth sores caused by cancer treatment or other conditions) and for herpes labialis, which is the medical name for cold sores. For diabetes, the evidence is also possibly effective.
The evidence for dengue fever is insufficient to rate it either way — we just don't have enough reliable data.
How safe is it?
Well-documented data
Propolis is generally well tolerated when taken short-term. The most common side effect is mild headache — about 7% of people in one trial taking 250 mg twice daily for four months reported it.
The main caution is allergic reactions, especially if you're sensitive to bee products or have a known bee allergy; severe allergic reactions are rare but possible. There isn't enough safety information to use this during pregnancy or while breastfeeding — the data advises against both.
Meds to double-check
Moderate interaction found
Check with us if you take blood thinners or antiplatelet drugs (like aspirin or clopidogrel), warfarin (Coumadin), or any medications broken down by your liver — that includes many antidepressants, heart drugs, and pain relievers. The interactions are Moderate across all these categories.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bee Propolis Ultimate is worth considering if you have mouth sores, cold sores, or want to explore blood sugar support and you don't take blood thinners or warfarin. If you're on any prescription medications that your liver processes, or if you have a bee allergy, talk to your pharmacist before you start.
Definitely check your exact medications with the tool on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bee Propolis Ultimate, straight from the product label.
| Brand | NaturaNectar |
|---|---|
| Barcode (UPC) | 837654326619 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 320727 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bee Propolis Ultimate by NaturaNectar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Flav-B | 50 mg | -- |
| Flav-R | 50 mg | -- |
| Flav-G | 50 mg | -- |
| PWE-RD | 3 mg | -- |
| PWE-GD | 3 mg | -- |
| PWE-MD | 3 mg | -- |
Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
NaturaNectar A trusted brand based on our scientific understanding of the magnificent benefits of honeybees and their bee propolis
At NaturaNectar, we understand the nature and science behind the beehive and find our inspiration there. With the same focus and dedication of the honeybees to build sustainable and productive hives with their propolis, our company is dedicated to bringing you wellness products imbued with the same protective propolis to help you live an active and healthy life. We commit our corporate resources to the vital research needed to ensure that honeybees continue to be nature's true marvels as well as supporting the surrounding communities that help harvest our bee propolis in a sustainable way. We invite you to learn more at beethereinitiative.com
The mission of NaturaNectar is to protect and activate wellness naturally through our commitment to developing trusted, science-based, doctor-formulated products while being socially and enviromentally responsible.
Protect & Activate wellness naturally
Bee Propolis Ultimate Today we are exposed to more noise, pollution, and life challenges than ever before, creating a potential overload that can threaten our wellness, mental alertness and happiness.
Naturanectar.com/bee-propolis-ultimate
Please recycle
Seals/Symbols
Technology from Denmark Made in USA from International Ingredients Premium Brazilian Propolis
G Extraction NSF Contents Certified
Formulation
Quality from the source. NaturaNectar's sister company ALMAR Apiary is located in beautiful Brazil, the home of the verdant rain forests, where the world's finest and purest bee propolis is harvested. Our ground breaking and effective products are sourced for you directly from the Brazilian honeybees and their bio diverse forests! 30+ Years perfecting the most advanced standardized propolis extracts Through our partnership with PRC-Propolis Research Center, our standardized, 100% water-based pure propolis extracts have become the foundation of NaturaNectar's extensive product line.
Activate wellness of multiple body cells & systems Natural ingredients
Gluten free
Like the bees that protect their hives and health with their propolis, NaturaNectar's Bee Propolis Ultimate supplement can uniquely support your health.
This product supports the Health of: Systems Cardiovascular Respiratory Endocrine Reproductive Immune Circulatory Nervous Hepatic Cells Lung Pancreas Blood Skin/Nail/Hair Liver Breast Brain Heart Prostate Larynx Mucous Membrane
FLAV and PWE extracts are obtained by NaturaNectar's exclusive Green Extraction for purity, standardization and potency
NaturaNectar Bee Propolis Ultimate does not contain alcohol, sugar, starch, wheat, gluten, yeast, milk (lactose), egg, shellfish, artificial preservatives, flavors, dyes or colors.
Suggested/Recommended/Usage/Directions
One A Day
Directions: Take one capsule by mouth once a day to support overall health. Consult your practitioner for higher dosages
Formula
Hundreds of active compounds Premium red, green & brown propolis
An exclusive formula that features concentrated dosages of flavonoids and organic aromatic acids (OAA) from premium Brazilian red, green and brown propolis. It is a natural source of acclaimed active compounds Artepillin-C, Cape (Caffeic acid phenethyl ester), Vestitol, Neo-Vestitol, Formononetin and over 300 other natural compounds beneficial to your health. These exotic and exclusive types of Brazilian propolis are appreciated for their exclusive properties backed by hundreds of scientific studies. All captured in just one capsule!
FDA Statement of Identity
Daily Dietary Supplement
Brand IP Statement(s)
NaturaNectar My Wellness Zone
Copyright 2013 NaturaNectar LLC
Precautions
Caution: As with any nutritional supplement, it is advised to consult your physician before taking, especially if pre-existing conditions are present.
Do not take if pregnant or breastfeeding.
Use with caution if allergic to bee products.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bee Propolis Ultimate by NaturaNectar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bee Propolis Ultimate by NaturaNectar
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Flav-B
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Flav-B monograph & interactionsFlav-R
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Flav-R monograph & interactionsFlav-G
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Flav-G monograph & interactionsPWE-RD
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
PWE-RD monograph & interactionsPWE-GD
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
PWE-GD monograph & interactionsPWE-MD
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
PWE-MD monograph & interactionsOther (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Bee Propolis Ultimate by NaturaNectar Drug Interactions
HelloPharmacist Interaction Report
Bee Propolis Ultimate by NaturaNectar contains six propolis extracts, and each one has documented Moderate interactions with multiple drug types.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — propolis may increase your bleeding risk by affecting how platelets clump together. This is a real interaction to watch for.
Read the full breakdown — every affected drug type, severity by severity
Propolis also theoretically raises blood levels of drugs metabolized through several liver pathways (CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1). Lab research shows this is possible, but animal studies suggest it may not happen at typical doses.
Still, if you take medications broken down by your liver, this matters.
One more: propolis may decrease how well warfarin (Coumadin) works, based on animal research. This hasn't been reported in humans yet, but if you're on warfarin, you need to check with us before starting.
Altogether, these interactions span 911 individual medications. Run your exact drugs through the checker on this page before you begin.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bee Propolis Ultimate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bee Propolis Ultimate interact with 921 drugs. Click any drug to see the details.
1 of the 6 ingredients in Bee Propolis Ultimate interact with drugs. Each result below shows which ingredient is responsible. Flav-B
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Pwe-md + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Pwe-md + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Pwe-md + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Pwe-md + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Pwe-md + Acetaminophen, Meperidine interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Bee Propolis Ultimate — through 1 ingredient. Tap an ingredient for the detail:
Pwe-mdCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Pwe-md + Acetaminophen, Orphenadrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bee Propolis Ultimate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Flav-B
Anticoagulant/Antiplatelet Drugs
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Bee Propolis Ultimate, from the product label.
NaturaNectar
See all NaturaNectar products- Name
- NaturaNectar LLC
- Street Address
- 4631 NW 103rd Ave.
- City
- Sunrise
- State
- FL
- ZipCode
- 33351
- Phone Number
- 800.609.7794
- Web Address
- naturanectar.com
Bee Propolis Ultimate by NaturaNectar: Common Questions
Does Bee Propolis Ultimate by NaturaNectar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm allergic to bees?
What's the most common side effect?
Will this help my cold sore or mouth sores?
Can I take this while pregnant or breastfeeding?
Why are there six different propolis ingredients in one capsule?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bee Propolis Ultimate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bee Propolis Ultimate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bee Propolis Ultimate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Propolis 21 references
- Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
- Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
- Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
- Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
- Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
- Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
- Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
- Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
- Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
- Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
- Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
- Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC