Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Belly Off Ingredients & Drug Interactions

by BioGenetic Laboratories

Belly Off label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Belly Off against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Belly Off is a dietary supplement by BioGenetic Laboratories with 4 active ingredients. Its ingredients are commonly taken for energy and alertness, reducing fatigue, weight loss support.Based on those ingredients, 1,102 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yerba Mate (herb) (leaf) extract, Guarana (seed) extract, Damiana (leaf) 4:1 concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Belly Off by BioGenetic Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Belly Off by BioGenetic Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Belly Off by BioGenetic Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “YGD(TM) Weight-Loss Blend” is a proprietary blend — the label gives one combined amount (381 mg) without saying how much of each component you get.

Belly Off contains 4 active ingredients. Conjugated Linoleic Acid is a fatty acid compound.

The product also includes guarana seed extract and yerba mate leaf extract, both natural sources of caffeine used traditionally for energy and metabolism support. Damiana leaf concentrate is included as well.

The product is formulated in a softgel capsule with gelatin, monoglycerides, yellow beeswax, and lecithin as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight loss and reduce belly fat.
  • We looked for evidence on: Obesity, Body composition, Waist circumference, Fat mass reduction.
  • The closest evidence on file: Damiana is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Yerba Mate is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Guarana is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence for Belly Off's ingredients isn't established in the data we hold. Guarana has insufficient reliable evidence for cancer-related anorexia, anxiety, athletic performance, cancer-related fatigue, and chemotherapy-related fatigue.

Yerba mate is also insufficiently studied for arrhythmia, athletic performance, osteoporosis, chronic fatigue, headache, and cognitive function. Damiana similarly lacks reliable evidence for sexual dysfunction, asthma, headache, cognitive function, constipation, and depression.

We can't tell you whether this product will help with weight loss or any other claimed benefit based on the safety and effectiveness data available.

The evidence, ingredient by ingredient Guarana Yerba Mate Damiana

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guarana and yerba mate are generally well tolerated in small amounts, but both are high in caffeine, which can cause stomach upset, nausea, dizziness, insomnia, nervousness, and tremors, especially with larger doses. The safety data advises against guarana during pregnancy and recommends limiting it while breastfeeding since caffeine passes into breast milk.

Yerba mate is considered possibly unsafe in pregnancy and should be limited or avoided while breastfeeding. Damiana has very limited human safety data, so it's best avoided during pregnancy and breastfeeding.

In rare cases at high doses, guarana and yerba mate may cause serious effects, and damiana at very high doses has caused severe muscle contractions.

Side effects, ingredient by ingredient Guarana Yerba Mate Damiana

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Damiana, Yerba Mate, Guarana.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,103 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Belly Off, have your pharmacist review any prescription medications you take. Most important: ephedrine or ephedrine-containing products (Major severity risk).

Also double-check seizure drugs like valproate or carbamazepine, antidepressants like fluvoxamine, the antipsychotic clozapine, diabetes medications, disulfiram (Antabuse), dipyridamole (Persantine), felbamate (Felbatol), and quinolone antibiotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Belly Off is primarily a caffeine-containing product, so it's not suitable if you take ephedrine or certain seizure, heart, antidepressant, or antipsychotic medications. If you take any prescription drug, especially for diabetes, heart rhythm, or mental health, check it with your pharmacist before starting.

Pregnant people and those breastfeeding should talk to their doctor first due to the caffeine content and limited safety data for damiana.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Belly Off, straight from the product label.

Brand BioGenetic Laboratories
Net contents 90 Softgel Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18855
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Belly Off by BioGenetic Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
90
IngredientAmount% DV
Conjugated Linoleic Acid1000 mg--
YGD(TM) Weight-Loss Blend381 mg--
Guarana (seed) extract0 NP--
Yerba Mate (herb) (leaf) extract0 NP--
Damiana (leaf) 4:1 concentrate0 NP--

Other ingredients: Gelatin, MONGLYCERIDES, Yellow Beeswax, Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

^These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Individuals results may and will differ. Always consult a physician prior to any diet or exercise program.

INCLUDES FREE DIET PLAN! (Inside!)

CAN CLA HELP YOU LOSE BELLY FAT? Three new published research studies reveal that losing weight and reducing bodyfat, especially around the waist, could be easy as taking a daily CLA supplement... and now combined with a new weight-loss blend, suggest is may make the weight loss easier and more profound. STUDY #1: The US study set out to investigate conjugated linoleic acid (CLA, naturally derived from safflower oil) and included 40 overweight adults. For the duration of the study, participants took either CLA or a placebo (a pill that contains no active ingredients). During this time, the participants were asked not to change their diets. The researchers found those taking CLA lost significantly more bodyfat and weight than those taking the placebo. That's not all. During November and December (the US holiday season), those participants in the study taking the placebo gained more weight than those taking CLA. STUDY #2: More recently, at the Experimental Biology medical conference, scientists presented a fascinating study in which another group was supplemented with CLA or CLA plus guarana. After only 6 weeks, both groups showed a substantial reduction in fat mass. In the CLA-only group, the decrease in fat mass was due to a reduction in fat-cell size, without a change in fat-cell number. In the CLA plus guarana group, both fat-cell size and number were reduced by 50% over the CLA-only group. (FASEB 2002). STUDY #3: A study recently published in the International Journal of Obesity concluded that CLA reduces abdominal fat among men classified as abdominally obese. This double-blind, randomized, placebo-controlled trial observed 25 men with significant abdominal fat for four weeks. At the conclusion of the study, the participants taking CLA lost an average of 1.4 cm in waist circumference (abdominal diameter) after only four weeks. What's interesting is that none of the study participants changed their eating or exercise habits during the trial period. Start today, and although results may vary, you could experience similar results to those test subjects in the most recent clinical studies, such as: -Reduced appearance of belly fat^* -Help curbing hunger and boosting energy^* -Support losing more bodyweight than diet alone, feeling lighter, healthier, and more confident^*

*SCIENTIFIC STUDIES ON INGREDIENTS IN BELLY-OFF: 1) Med Sci Sports Exerc. 2004 May;36(5):814-20. 2) Eur Jclin Nutr. 2003 Apr;57(4):595-603. 3) Br J Nutr. 2002 Sep;88(3):243-51. 4) Lipids. 2001 Mar;36(3):221-7. 5) Am J Clin Nutr. 2004 Jun;79(6):1118-25. 6) J Int Med Res. 2001 Sep-Oct;29(5):392-6. 7) Int J Obes relat metab Disord. 2001 Aug;25(8):1129-35. 8) Lipids. 2001 Aug;36(8):773-81. 9) J Nutr. 2000 Dec;130(12):2943-8. 10) J Nutr. 2007 May;137(5):1188-93. 11) Br J Nutr. 2007 May;97(5):1001-11. 12) Br J Nutr. 2007 Mar;97(3):550-60. 13) Br J Nutr. 2007 Feb;97(2):273-80. 14) Int J Obes (Lond). 2007 Mar;31(3):481-7. 15) Am J Clin Nutr. 2007 May;85(5):1203-11. 16) J Pharm Pharmacol. 1992 Sep;44(9):769-71. For full scientific references, visit BioGeneticLabs.com

NEW WEIGHT LOSS BREAKTHROUGH

CLINICAL STUDIES on the key ingredients, over 6 weeks, suggest they may help: -Reduce the appearance of belly fat^* -Curb hunger and boost energy^* -Support losing more bodyweight than diet alone, feeling lighter, healthier, and more confident^*

{f} Come join the thousands of others who are enjoying their new, thinner, lighter, and more energetic bodies, and see them sharing their successful weight-loss stories: facebook.com/BioGeneticLabs

Made in the USA with ingredients of international and domestic origin.

QUALITY SATISFACTION GUARANTEE: If, for whatever reason, you are not satisfied, return it to your original place of purchase for the appropriate refund.

If you or your doctor has any questions about this product, please call 1-888-752-6615.

Seals/Symbols

CLINICALLY RESEARCHED KEY INGREDIENTS

MADE IN THE USA

Brand IP Statement(s)

CLA + YGD(TM) Weight-Loss Blend

CUSTOMER REVIEWS FOR THE Belly Off(TM) DIETER'S WEIGHT LOSS SYSTEM: "{star}{star}{star}{star}{star}" "Thankfully, Belly-Off does what is says it will do, without any crazy dieting!" -Mary N., 47 "This product works fast, I could feel it right away. I love Belly-Off!" -SoccerMom8609, via email "Simply put, this product is amazing! I can finally get a flat, sexy tummy again!" -Angie P., 39

(c) 2012 iSatori, Inc.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR USE: As a dietary supplement, adults take 2 to 3 servings with each morning and afternoon meal, or as recommended by a physician. Please read the entire label carefully before use, and follow the diet plan (free inside). NOTICE: FOR BEST RESULTS, FOLLOW THE SCIENTIFICALLY DESIGNED DIET PLAN INCLUDED.

Precautions

Individuals who are sensitive to caffeine should begin use with one-half the recommended dosage and limit the use of other caffeine-containing foods and drinks while taking this product because too much caffeine may cause nervousness, irritability, and sleeplessness. DO NOT USE IF SAFETY SEAL UNDER CAP IS BROKEN.

Improper use of this product will not improve results and is not advised. Only follow a reduced calorie diet under the supervision of a doctor.

Consult with your primary physician prior to use if you have any pre-existing medical conditions, including high blood pressure, thyroid problems, nervous disorders, or if you are using MAO inhibitors or taking any prescription drugs.

NOTICE: KEEP OUT OF REACH OF CHILDREN. Not intended for individuals under the age of 18, unless instructed by a doctor.

Consult your physician prior to use if you have high blood pressure or heart problems or are taking prescription drugs.

Do not exceed the recommended daily intake. Seek the advice of a healthcare professional before beginning any supplement or exercise program.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Belly Off by BioGenetic Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Belly Off label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Belly Off by BioGenetic Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Conjugated Linoleic Acid

1000 mg per serving Form: Safflower Oil

YGD(TM) Weight-Loss Blend

381 mg per serving

Other (inactive) ingredients: Gelatin, MONGLYCERIDES, Yellow Beeswax, Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Belly Off by BioGenetic Laboratories Drug Interactions

Want to check YOUR meds against Belly Off?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,102Drugs
8 Major 588 Moderate 506 Minor

Ingredients driving the most interactions

Yerba Mate (herb) (leaf) extract 1,086
Guarana (seed) extract 655
Damiana (leaf) 4:1 concentrate 86

Individual Drug Interactions

The ingredients in Belly Off interact with 1,102 drugs. Click any drug to see the details.

3 of the 4 ingredients in Belly Off interact with drugs. Each result below shows which ingredient is responsible. Yerba Mate (herb) (leaf) extract Guarana (seed) extract Damiana (leaf) 4:1 concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Belly Off with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Yerba Mate (herb) (leaf) extract43 drug types · 1,086 drugs

Ephedrine

Theoretically, the caffeine in yerba mate might increase the risk for stimulant adverse effects when used concomitantly with ephedrine.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, the caffeine in yerba mate might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Yerba mate contains caffeine. Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. Still, some researchers recommend that methylxanthines, such as caffeine, as well as methylxanthine-containing products, should be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, the caffeine in yerba mate may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Yerba mate contains caffeine. Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, the caffeine in yerba mate might reduce the efficacy of benzodiazepines.
Yerba mate contains caffeine. Caffeine can antagonize the anxiolytic effects of benzodiazepines.

Likelihood Probable Evidence D
Beta-Adrenergic Agonists

Theoretically, the caffeine in yerba mate might increase the cardiac inotropic effects of beta-agonists, especially if taken in large amounts.
Yerba mate contains caffeine. Caffeine can increase cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, the caffeine in yerba mate might reduce the effects of carbamazepine and increase the risk for convulsions.
Yerba mate contains caffeine. Animal research suggests that caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine two-fold in healthy individuals.

Likelihood Possible Evidence B
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of the caffeine contained in yerba mate.
Yerba mate contains caffeine. Cimetidine decreases caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Theoretically, the caffeine in yerba mate might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Yerba mate contains caffeine. Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, the caffeine in yerba mate might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Yerba mate contains caffeine. Caffeine inhibits dipyridamole-induced vasodilation. Still, some researchers recommend that methylxanthines, such as caffeine, as well as methylxanthine-containing products, should be stopped 24 hours prior to pharmacological stress. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.
Yerba mate contains caffeine. Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, the caffeine in yerba mate might reduce the effects of ethosuximide and increase the risk for convulsion.
Yerba mate contains caffeine. Animal research shows that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, the caffeine in yerba mate might reduce the effects of felbamate and increase the risk for convulsion.
Yerba mate contains caffeine. Animal research shows that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, the caffeine in yerba mate might increase the levels and adverse effects of flutamide.
Yerba mate contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt withdrawal of the caffeine in yerba mate might increase serum lithium levels.
Yerba mate contains caffeine, which has diuretic activity. When abruptly discontinued, it might alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Probable Evidence D
Midazolam (Versed)

Theoretically, use of yerba mate with midazolam might increase midazolam metabolite levels and adverse effects.
In vitro research shows that yerba mate extract containing 6.75% chlorogenic acid significantly inhibits the metabolism of midazolam via inhibition of cytochrome P450 3A4 (CYP3A4).

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, the caffeine in yerba mate might increase risk of a hypertensive crisis when used concomitantly with MAOIs.
Yerba mate contains caffeine. Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, the caffeine in yerba mate might increase risk of hypertension when used concomitantly with nicotine.
Yerba mate contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence D
Pentobarbital (Nembutal)

Theoretically, the caffeine in yerba mate might decrease the effects of pentobarbital.
The caffeine in yerba mate might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, the caffeine in yerba mate might reduce the effects of phenobarbital and increase the risk for convulsions.
Yerba mate contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension as well as the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, the caffeine in yerba mate might reduce the effects of phenytoin and increase the risk for convulsions.
Yerba mate contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence B
Pioglitazone (Actos)

Theoretically, the caffeine in yerba mate might increase the levels and clinical effects of pioglitazone.
Yerba mate contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Yerba Mate (herb) (leaf) extract full monograph & all 43 interactions

Guarana (seed) extract41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Guarana contains caffeine. Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, guarana might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Guarana contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that guarana extract can inhibit platelet aggregation. This effect may be due to the caffeine in guarana, which is also reported to have antiplatelet activity. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, concomitant use might increase the clinical effects of beta-adrenergic agonists.
Guarana contains caffeine. Theoretically, concomitant use of large amounts of caffeine might increase cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, guarana might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when given to animals in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine two-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, concomitant use might increase the effects and adverse effects of caffeine in guarana.
Guarana contains caffeine. Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Theoretically, guarana might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Guarana contains caffeine. Caffeine can increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Researchers speculate that caffeine might inhibit CYP1A2. However, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to the interaction between clozapine and caffeine.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, guarana might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Guarana contains caffeine. Caffeine might inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
In human research, disulfiram decreases the clearance and increases the half-life of caffeine.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, using guarana with diuretic drugs might increase the risk of hypokalemia.
Guarana contains caffeine. Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Guarana contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, guarana might reduce the effects of ethosuximide and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. This effect has not been observed in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, guarana might reduce the effects of felbamate and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. This effect has not been observed in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, guarana might increase the levels and adverse effects of flutamide.
Guarana contains caffeine. In vitro evidence shows that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Guarana contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt guarana withdrawal might increase the levels and adverse effects of lithium.
Guarana contains caffeine. Theoretically, abrupt caffeine withdrawal might increase serum lithium levels. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Guarana contains caffeine. Caffeine has been shown to inhibit MAO-A and -B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Guarana contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence D
Pentobarbital (Nembutal)

Theoretically, guarana might decrease the effects of pentobarbital.
Guarana contains caffeine. In vivo evidence suggests that caffeine can negate the hypnotic effects of pentobarbital in humans. However, animal research suggests that guarana does not alter the hypnotic effect of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, guarana might reduce the effects of phenobarbital and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Guarana contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, guarana might reduce the effects of phenytoin and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, guarana might increase the levels and clinical effects of pioglitazone.
Guarana contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Guarana contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Guarana contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.

Likelihood Possible Evidence D
Guarana (seed) extract full monograph & all 41 interactions

Damiana (leaf) 4:1 concentrate1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.

Likelihood Possible Evidence D
Damiana (leaf) 4:1 concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Belly Off, from the product label.

BioGenetic Laboratories

See all BioGenetic Laboratories products
Name
BioGenetic Laboratories a division of iSatori Technologies
Street Address
15000 W. 6th Ave., Ste. #202
City
Golden
State
CO
ZipCode
80401
Phone Number
1-888-752-6615
Web Address
www.BioGeneticLabs.com
Pharmacist Counseling Corner

Belly Off by BioGenetic Laboratories: Common Questions

Does Belly Off by BioGenetic Laboratories interact with any medications?
Yes. Based on its ingredients, Belly Off has a known interaction with 1,102 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Belly Off contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Belly Off if I'm pregnant or breastfeeding?
Guarana is best avoided during pregnancy because it's high in caffeine. Yerba mate is considered possibly unsafe in pregnancy, so check with your doctor first. Both pass caffeine into breast milk, so they're best limited or avoided while nursing. Damiana has insufficient safety data, so it should also be avoided in pregnancy and breastfeeding. Talk to your pharmacist or doctor for personalized advice.
What are the main side effects I might experience?
Because Belly Off is high in caffeine (from guarana and yerba mate), the most common side effects are stomach upset, nausea, dizziness, insomnia, nervousness, restlessness, and tremors. In sensitive people, caffeine can rarely trigger anaphylaxis. At very high doses, damiana has caused severe muscle contractions. Most people tolerate it well in normal amounts.
Does Belly Off actually work for weight loss?
The evidence for Belly Off's ingredients isn't established in the data we hold. We can't tell you whether it will help with weight loss based on the safety and effectiveness information available.
Why can't I take this with ephedrine?
Guarana and yerba mate both contain caffeine, and combining caffeine with ephedrine (a stimulant) can increase the risk of serious problems like heart issues, seizures, and even temporary loss of consciousness. It's a Major severity interaction.
What's the caffeine content in Belly Off?
The product facts don't specify the exact amount of caffeine from guarana and yerba mate in each dose, so ask your pharmacist for that detail.
Are there any fillers or inactive ingredients I should know about?
Belly Off contains gelatin, monoglycerides, yellow beeswax, and lecithin as inactive ingredients. If you have allergies or sensitivities to any of these, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Belly Off is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Belly Off label
Go deeper

The Full Monographs Behind Belly Off’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guarana

Interacts with 655 drugs

Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects. While it may give a short-term boost in alertness and reduce fatigue...

Read the full Guarana monograph → Herb & supplement monograph

Yerba Mate

Interacts with 1,086 drugs

Yerba mate is a caffeine-containing herbal beverage from South America that is widely enjoyed for its stimulating, coffee-like effects. While it is rich in antioxidants and is being studied...

Read the full Yerba Mate monograph → Herb & supplement monograph

Damiana

Interacts with 86 drugs

Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small am...

Read the full Damiana monograph →
Sources

Sources & How We Checked

Belly Off's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 239 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guarana 114 references
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See these in context on the Guarana monograph →

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See these in context on the Yerba Mate monograph →

Damiana 2 references
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  2. Alarcon-Aquilar FJ, Roman-Ramos R, Perez-Gutierrez S, et al. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol 1998;61:101-10. PubMed

See these in context on the Damiana monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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