Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Benfotiamine 150 mg Ingredients & Drug Interactions

by Klaire Labs

Benfotiamine 150 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Benfotiamine 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Benfotiamine 150 mg is a dietary supplement by Klaire Labs with 2 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Benfotiamine 150 mg by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Benfotiamine 150 mg by Klaire Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Benfotiamine 150 mg by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: thiamine and benfotiamine. Thiamine is the water-soluble B vitamin your body needs for energy metabolism and nerve function.

Benfotiamine is a fat-soluble form of thiamine designed to be absorbed more readily into tissues like nerves and eyes. The capsule itself is vegetarian, and the inactive ingredients are microcrystalline cellulose (a binder), L-leucine, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Vitamin B1 supplement.
  • We looked for evidence on: Thiamine deficiency, Wernicke-Korsakoff syndrome (WKS), Diabetic neuropathy, Peripheral neuropathy, Alcohol use disorder, Beriberi — and 2 related terms.
  • The strongest evidence on file: Thiamine is rated "Effective" for Thiamine deficiency (Natural Medicines).
  • Also on file: Thiamine is rated "Effective" for Wernicke-Korsakoff syndrome (WKS).
  • Also on file: Benfotiamine is rated "Possibly Effective" for Diabetic neuropathy.

Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome (a serious condition caused by severe thiamine lack). It's possibly effective for menstrual cramps.

Benfotiamine shows possibly effective evidence for diabetic nerve pain, but the data is insufficient for Alzheimer's disease, peripheral neuropathy, and alcohol use disorder. The evidence doesn't support either ingredient for heart failure or as a mosquito repellent.

The evidence, ingredient by ingredient Thiamine Benfotiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very safe by mouth at normal doses; allergic skin reactions are rare. Benfotiamine is generally well tolerated in studies, though long-term safety isn't fully known.

In one trial, a small number of people reported allergic skin reactions or mild stomach discomfort, at rates no different from placebo. Thiamine is needed in pregnancy and while breastfeeding and is rated likely safe, but use supplement doses only as advised by your provider.

Safety information for benfotiamine in pregnancy and breastfeeding is limited, so discuss this with your doctor or pharmacist before using it in these situations.

Side effects, ingredient by ingredient Thiamine Benfotiamine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Thiamine.
  • The most serious interaction on file is rated Minor.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take trimethoprim (an antibiotic), check with your doctor or pharmacist before starting this product—thiamine levels in your blood may rise. No other interactions are documented for the ingredients we could check, but run your full medication list through the search tool on this page to be thorough.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product may help with thiamine deficiency or Wernicke-Korsakoff syndrome, and benfotiamine might offer some benefit for diabetic nerve pain. If you take trimethoprim or other antibiotics, check the interaction tool first and confirm with your doctor or pharmacist.

If you're pregnant or breastfeeding, talk with your provider before starting—they can advise you on whether this supplement is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Benfotiamine 150 mg, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 828054001275
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 280436
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Benfotiamine 150 mg by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
828054001275
IngredientAmount% DV
Thiamine150 mg12500%
Benfotiamine150 mg--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, L-Leucine, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule daily with food or as directed by a healthcare professional.

Formula

Benfotiamine is a lipid-soluble derivative of vitamin B1 (thiamin) with high bioavailability. It is better absorbed than water-soluble forms of thiamin and has an estimated bioavailability of up to 3.6 times as high as compared to thiamin hydrochloride, making benfotiamine especially useful for people with absorption difficulties.

Precautions

Do not use if shrinkwrap is broken or missing.

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Vitamin B1 Supplement

Brand IP Statement(s)

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Benfotiamine 150 mg by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Benfotiamine 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Benfotiamine 150 mg by Klaire Labs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamine

Interacts with
3 drugs
150 mg per serving Form: Benfotiamine

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Benfotiamine

No known
interactions
150 mg per serving Form: S-Benzoylthiamine-O-Monophosphate

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, L-Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Benfotiamine 150 mg by Klaire Labs Drug Interactions

Want to check YOUR meds against Benfotiamine 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in Benfotiamine 150 mg interact with 3 drugs. Click any drug to see the details.

1 of the 2 ingredients in Benfotiamine 150 mg interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Benfotiamine 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Benfotiamine 150 mg, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Benfotiamine 150 mg by Klaire Labs: Common Questions

Does Benfotiamine 150 mg by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Benfotiamine 150 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Benfotiamine 150 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between thiamine and benfotiamine?
Thiamine is a water-soluble B vitamin your body needs for energy and nerve function. Benfotiamine is a fat-soluble form designed to be absorbed more easily into nerve and eye tissue. Both are forms of the same vitamin, but benfotiamine may reach certain tissues better.
Is this safe if I'm pregnant or breastfeeding?
Thiamine is needed in pregnancy and while breastfeeding and is rated likely safe, but use only the amounts your doctor or pharmacist advises. Benfotiamine hasn't been well studied in pregnancy or breastfeeding, so there isn't enough data to know either way. Talk with your provider before taking this supplement in these situations.
Can benfotiamine help with Alzheimer's disease?
The evidence isn't established in the data we hold. While benfotiamine has been studied for this, there's insufficient reliable evidence to rate whether it works, so we can't say either way.
What side effects might I experience?
Both ingredients are generally well tolerated. Allergic skin reactions are rare with thiamine taken by mouth. In studies of benfotiamine, a small number of people reported mild skin reactions or slight stomach discomfort, but these occurred at rates no different from placebo.
Will this help with diabetic nerve pain?
Benfotiamine is possibly effective for diabetic nerve pain based on available evidence. Talk with your doctor about whether it might be right for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Benfotiamine 150 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Benfotiamine 150 mg label
Go deeper

The Full Monographs Behind Benfotiamine 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph →
Sources

Sources & How We Checked

Benfotiamine 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team