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Dietary supplement

Bergamot Extract BPF Ingredients & Drug Interactions

by Adaptogen Research

Bergamot Extract BPF label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bergamot Extract BPF against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bergamot Extract BPF is a dietary supplement by Adaptogen Research with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart and metabolic health, anxiety and stress (aromatherapy).Based on those ingredients, 410 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bergamot Polyphenolic Fraction Gold. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bergamot Extract BPF by Adaptogen Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Bergamot Extract BPF by Adaptogen Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bergamot Extract BPF by Adaptogen Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Bergamot Polyphenolic Fraction Gold, an extract from bergamot that concentrates the plant's polyphenolic compounds — the compounds many of its potential benefits come from. The tablet also contains several inactive ingredients (fillers and binders) including croscarmellose sodium, microcrystalline cellulose, and silica to hold it together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy cholesterol and blood glucose metabolism.
  • We looked for evidence on: Hyperlipidemia, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Nonalcoholic fatty liver disease (NAFLD), Dyslipidemia, Insulin resistance.
  • The strongest evidence on file: Bergamot is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Bergamot is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Impaired glucose tolerance (prediabetes), Metabolic syndrome.

Bergamot extract is possibly effective for high cholesterol (hyperlipidemia) based on the evidence we hold. For mental alertness, it's rated possibly ineffective.

For nonalcoholic fatty liver disease and autism spectrum disorder, the evidence isn't established enough to say one way or the other — more research would be needed.

The evidence, ingredient by ingredient Bergamot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, bergamot extract appears generally well tolerated when used short-term. One person in clinical research reported heartburn.

The oral extract itself is much safer than the essential oil, which can be toxic if swallowed and cause sun-related skin reactions, especially on fair skin. Safety in pregnancy and while breastfeeding hasn't been adequately studied — the data advises against using it during either time.

Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Bergamot

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bergamot.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 410 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Bergamot Extract BPF, check whether you take any photosensitizing drugs (Moderate severity) — these increase sun sensitivity, and bergamot may add to that risk. Also double-check if you're on diabetes medication (Moderate severity), since bergamot may lower blood sugar.

Run your exact medications through the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have high cholesterol and want to explore natural options, bergamot extract may be worth discussing with your doctor — it's been studied for that purpose. If you take diabetes medication or use a photosensitizing drug (especially topically), check with your doctor or pharmacist first.

Avoid it during pregnancy and while breastfeeding. It's generally well tolerated orally in the short term, but talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bergamot Extract BPF, straight from the product label.

Brand Adaptogen Research
Barcode (UPC) 722537497947
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 307148
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bergamot Extract BPF by Adaptogen Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
722537497947
IngredientAmount% DV
Bergamot Polyphenolic Fraction Gold1.3 Gram(s)--

Other ingredients: Croscarmellose Sodium, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica, Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one to two tablets daily, or as directed by your healthcare practitioner.

Precautions

Consult your healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Storage: Keep closed in a cool, dry place out of reach of children.

Report any adverse reaction on adaptogenresearch.com

Professional Use Only

Formula

Bergamot Extract BPF features a highly concentrated source of polyphenolic antioxidants derived from bergamot (Citrus bergamia), a flavonoid-rich fruit originating from the Calabria region in southern Italy and traditionally used to support cardiovascular wellness.

Cardiovascular and blood sugar support from bergamot

Formulation

Research has suggested that Bergamot Polyphenolic Fraction Gold (BPFG) is utilized hepatically to help maintain healthy cholesterol levels already within normal range and to support healthy blood glucose metabolism.

Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Made with non-GMO ingredients Does not contain gluten

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

S1. Bergamot Polyphenolic Fraction Gold (BPFG) is a registered trademark of H&AD S.R.L.

Seals/Symbols

Guaranteed GMP Compliant Products

General Statements

This package is completely recyclable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bergamot Extract BPF by Adaptogen Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bergamot Extract BPF label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bergamot Extract BPF by Adaptogen Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Bergamot Polyphenolic Fraction Gold

Interacts with
410 drugs
1.3 Gram(s) per serving Form: Bergamot Fruit Juice Extract

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but...

Bergamot Polyphenolic Fraction Gold monograph & interactions

Other (inactive) ingredients: Croscarmellose Sodium, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica, Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bergamot Extract BPF by Adaptogen Research Drug Interactions

Want to check YOUR meds against Bergamot Extract BPF?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
410Drugs
410 Moderate

Ingredients driving the most interactions

Bergamot Polyphenolic Fraction Gold 410

Individual Drug Interactions

The ingredients in Bergamot Extract BPF interact with 410 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bergamot Extract BPF interact with drugs. Each result below shows which ingredient is responsible. Bergamot Polyphenolic Fraction Gold

Each ingredient & the kinds of drugs it affects

For each ingredient in Bergamot Extract BPF with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bergamot Polyphenolic Fraction Gold2 drug types · 410 drugs

Antidiabetes Drugs

Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that bergamot juice has hypoglycemic effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Bergamot contains bergapten, which has photosensitizing effects.

Likelihood Probable Evidence D
Bergamot Polyphenolic Fraction Gold full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bergamot Extract BPF, from the product label.

Adaptogen Research

See all Adaptogen Research products
Name
Adaptogen Research
Street Address
625 Barksdale Road, Suite 113
City
Newark
State
DE
ZipCode
19711
Web Address
adaptogenresearch.com
Pharmacist Counseling Corner

Bergamot Extract BPF by Adaptogen Research: Common Questions

Does Bergamot Extract BPF by Adaptogen Research interact with any medications?
Yes. Based on its ingredients, Bergamot Extract BPF has a known interaction with 410 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bergamot Extract BPF contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against bergamot during pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist about your options.
What is bergapten, and why does it matter?
Bergapten is a naturally occurring compound in bergamot that causes photosensitivity — it makes your skin more sensitive to sunlight. That's why bergamot oil can cause sun-related skin reactions, especially if you're using it topically or taking medications that also increase sun sensitivity.
Is the extract safer than bergamot oil?
Yes. The oral extract in this tablet is generally well tolerated. Bergamot essential oil, on the other hand, can be toxic if swallowed and is more likely to cause sun-related skin problems. This product uses the extract, so it's much safer orally than the oil would be.
Does bergamot actually lower cholesterol?
The evidence suggests it may help — it's rated possibly effective for high cholesterol. But it's not a replacement for prescription medications or lifestyle changes. Talk with your doctor about whether it fits into your overall plan.
What side effects should I watch for?
Taken by mouth, bergamot extract is generally well tolerated short-term. One person reported heartburn in research. Most side effects we know about happen when bergamot oil is used on the skin — blisters, redness, and pigment spots, especially in fair-skinned people or with sun exposure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bergamot Extract BPF is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bergamot Extract BPF label
Go deeper

The Full Monographs Behind Bergamot Extract BPF’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bergamot

Interacts with 410 drugs

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil i...

Read the full Bergamot monograph →
Sources

Sources & How We Checked

Bergamot Extract BPF's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bergamot 17 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. PubMed
  5. Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed
  6. Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. PubMed
  7. Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55.
  8. Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. PubMed
  9. Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. F PubMed
  10. Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. PubMed
  11. Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.P PubMed
  12. Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243.
  13. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-23 PubMed
  14. Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97.
  15. Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. PubMed
  16. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. I. Characterization and quantification of the photoactive component. Br.J.Dermatol. 1977;96(5):475-482. PubMed
  17. Bruno A, Pandolfo G, Crucitti M, Cedro C, Zoccali RA, Muscatello MRA. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study. J Clin Psychopharmacol 2017;37(4):468-71. PubMed

See these in context on the Bergamot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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