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Dietary supplement

Best Lutein 20 mg Ingredients & Drug Interactions

by Doctor's Best

Best Lutein 20 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Best Lutein 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Best Lutein 20 mg is a dietary supplement by Doctor's Best with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Best Lutein 20 mg by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Best Lutein 20 mg by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Best Lutein 20 mg by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Zeaxanthin” is listed as a grouped ingredient — the label gives one combined amount (4 mg) without saying how much of each component you get.

Best Lutein 20 mg contains two active carotenoid ingredients: lutein and zeaxanthin (a blend that includes meso-zeaxanthin). These are yellow and orange pigments naturally found in leafy greens and the human eye, where they're believed to filter damaging light and protect cells.

The softgel is made with sunflower oil, gelatin, glycerin, and purified water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: lutein and zeaxanthin for eye and retinal health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts — two common eye conditions tied to aging — but the evidence doesn't support its use for retinitis pigmentosa, retinopathy of prematurity, bronchopulmonary dysplasia, or necrotizing enterocolitis. Meso-zeaxanthin is also possibly effective for AMD, but there isn't enough reliable evidence yet to rate it for cognitive decline, Alzheimer disease, asthma, breast cancer, or other conditions listed in the research we hold.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from this supplement is generally well tolerated; studies of doses up to 20 mg daily haven't shown adverse effects. Meso-zeaxanthin is also generally well tolerated at typical supplement doses.

Both are rated Likely Safe in pregnancy and lactation, though the data on concentrated supplements (rather than food sources) during these periods isn't robust — talk with your doctor or pharmacist about your individual situation if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs — including insulin, metformin, sulfonylureas, or any other medication to lower blood sugar — check your exact medications with the search tool on this page before adding this product. There's a Moderate concern that zeaxanthin might increase the risk of low blood sugar.

Confirm with your doctor or pharmacist that it's safe to use together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may be worth considering if you're concerned about age-related macular degeneration or cataracts and want to add lutein and zeaxanthin to your routine. If you take antidiabetes medications, check your specific drugs and confirm with your doctor or pharmacist before starting.

Pregnant, planning to become pregnant, or breastfeeding? Discuss this with your healthcare provider to be sure it fits your needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Best Lutein 20 mg, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950003682
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 63231
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Best Lutein 20 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
753950003682
IngredientAmount% DV
Lutein20 mg--
Zeaxanthin4 mg--
Meso-Zeaxanthin1 mg--

Other ingredients: Sunflower Oil, Gelatin, Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

These carotenoids naturally accumulate in the retina and support healthy light sensing and glare control.* They are also excellent antioxidants.* Although meso-zeaxanthin is important for retinal health, it is very rare in the diet. This full-spectrum combination of retinal carotenoids promotes healthy visual function across the lifespan.* Enhances visual function* Promotes macular health* Supports the eyes during aging*

Scan for more info

CLINICALLY PROVEN FOR VISION AND EYE HEALTH*

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Lutemax is a registered trademark of OmniActive Technologies

Science-Based Nutrition

Lutemax 2020 LUTEIN & ZEAXANTHIN

FDA Statement of Identity

Dietary Supplement

Formula

Featuring Lutemax

Best Lutein Featuring Lutemax supplies lutein, zeaxanthin, and meso-zeaxanthin, the three carotenoid nutrients that predominate in the eye.

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 softgel daily, with or without food, or more, as recommended by a nutritionally-informed physician.

Formulation

Non-GMO and Gluten Free

General

YDRB368

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Best Lutein 20 mg by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Best Lutein 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Best Lutein 20 mg by Doctor's Best

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
20 mg per serving Form: Lutemax 2020 Marigold flower extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
4 mg per serving Form: Lutemax 2020 Marigold flower extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Best Lutein 20 mg by Doctor's Best Drug Interactions

Want to check YOUR meds against Best Lutein 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Best Lutein 20 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Best Lutein 20 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Best Lutein 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Best Lutein 20 mg, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
San Clemente
State
CA
ZipCode
92673
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Best Lutein 20 mg by Doctor's Best: Common Questions

Does Best Lutein 20 mg by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Best Lutein 20 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Best Lutein 20 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lutein, and why is it in here?
Lutein is a yellow pigment that's naturally in your eyes, leafy greens, and egg yolks. It's believed to protect your eyes from damage caused by light and aging. This supplement delivers 20 mg per dose, an amount that studies suggest may help protect against age-related macular degeneration and cataracts.
What about zeaxanthin and meso-zeaxanthin?
Both are related carotenoid pigments that work alongside lutein in the eye. Meso-zeaxanthin is a form of zeaxanthin found naturally in the retina. Together, these compounds are thought to protect eye health, and meso-zeaxanthin is also possibly effective for age-related macular degeneration.
Can I take this if I'm pregnant or breastfeeding?
Both lutein and meso-zeaxanthin are rated Likely Safe in pregnancy and lactation. However, most safety data comes from food sources rather than concentrated supplements, so there isn't a lot of information on high-dose supplements during these periods. Talk with your doctor or pharmacist about what's right for you.
Are there any side effects?
Lutein and meso-zeaxanthin are generally well tolerated at typical supplement doses. Studies of lutein at 20 mg daily haven't reported adverse effects, and meso-zeaxanthin is also well tolerated when used as directed.
Does this help with cataracts or macular degeneration?
The evidence suggests that lutein and meso-zeaxanthin are possibly effective for age-related macular degeneration and cataracts, meaning there's some support but it's not definitive. Talk with your eye doctor about whether adding this supplement makes sense for your individual situation.
What are the other ingredients — are there fillers?
The softgel capsule contains sunflower oil, gelatin, glycerin, and purified water as inactive ingredients — these are the materials that hold and deliver the active compounds.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Best Lutein 20 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Best Lutein 20 mg label
Go deeper

The Full Monographs Behind Best Lutein 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Best Lutein 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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