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Dietary supplement

Phosphatidyl Serine with SerinAid 100 mg Ingredients & Drug Interactions

by Doctor's Best

Phosphatidyl Serine with SerinAid 100 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidyl Serine with SerinAid 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidyl Serine with SerinAid 100 mg is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: phosphatidylserine, a naturally occurring compound found in cell membranes. The 100 mg dose is suspended in medium-chain triglycerides and soybean oil, with soy lecithin, oleic acid, and glycerin as additional inactive ingredients that help stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive function support.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), mental clarity, neurotransmitter function, brain health.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease based on available evidence. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the evidence we hold is insufficient to rate whether it works.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with insomnia more likely at higher doses (around 600 mg) and stomach upset possible at 200–300 mg per day.

There is not enough safety information available about use during pregnancy or while breastfeeding; talk with your doctor or pharmacist about whether this product is right for you if you are pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your doctor or pharmacist if you take anticholinergic drugs (for overactive bladder, Parkinson's disease, or other conditions) or cholinergic medications. Both interactions are moderate in severity and could affect how well your drugs work or cause added effects you don't want.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidylserine may be worth considering if you're dealing with age-related memory loss or Alzheimer disease and want a possibly effective option. If you take anticholinergic or cholinergic medications, you'll want to check with your doctor or pharmacist first.

Side effects are usually mild, but watch for stomach upset or sleep problems. Talk it over with your own healthcare provider to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidyl Serine with SerinAid 100 mg, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950001688
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 209417
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
753950001688
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Medium Chain Triglycerides, Soy Lecithin, Soybean Oil, Oleic Acid, Glycerin, Softgel capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Doctor's Best PhosphatidylSerine (PS) contains SerinAid, which provides a vital nutrient, PS, for the brain's nerve cell connections (synapses).

With SerinAid PhosphatidylSerine

Formulation

PS helps facilitate the activity of neurotransmitters involved in learning, memory, and mood. PS supports overall cognitive function, focus and mental clarity. PS and other phospholipids are structural components of brain neurons that can help enhance cell-to-cell communication. Numerous double-blind clinical trials document the benefits of PS for memory, learning, and other cognitive functions. PS may also help the body cope with occasional stress. Helps support memory, learning, and other cognitive functions. Helps support the brain and body in coping with occasional stress. Helps facilitate nerve cell connectivity.

Powerful memory support

Gluten free

This product contains natural ingredients that may vary in color.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Science-Based Nutrition

Precautions

Contains Soy

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 softgel 3 times daily with food, or as recommended by a nutritionally-informed physician.

Storage

Store in a cool dry place.

Brand IP Statement(s)

SerinAid is a registered trademark of Chemi Nutra.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidyl Serine with SerinAid 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: SerinAid

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Medium Chain Triglycerides, Soy Lecithin, Soybean Oil, Oleic Acid, Glycerin, Softgel capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best Drug Interactions

Want to check YOUR meds against Phosphatidyl Serine with SerinAid 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Phosphatidyl Serine with SerinAid 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phosphatidyl Serine with SerinAid 100 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidyl Serine with SerinAid 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phosphatidyl Serine with SerinAid 100 mg, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
State
California
ZipCode
92612
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best: Common Questions

Does Phosphatidyl Serine with SerinAid 100 mg by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Phosphatidyl Serine with SerinAid 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidyl Serine with SerinAid 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
There is not enough safety data available about phosphatidylserine during pregnancy or breastfeeding. It's best to avoid it in these situations and talk with your doctor or pharmacist about whether this product is safe for your specific circumstances.
What side effects should I watch for?
Most people tolerate it well, but you might notice flatulence, stomach upset, headache, nausea, or trouble sleeping — especially insomnia if you take higher doses. These side effects are most common when starting at 200–300 mg per day or higher.
Does this really help with memory loss?
Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease. For other uses like ADHD or general memory, the evidence we have is not strong enough to rate whether it works.
Why is one dose 100 mg when I've heard of higher doses?
This product delivers 100 mg per softgel. Many studies and marketed products use doses ranging from 100 mg up to 600 mg per day, depending on the condition being addressed — your doctor or pharmacist can advise the right amount for you.
Are there any fillers or things I should avoid in this softgel?
The inactive ingredients are medium-chain triglycerides, soy lecithin, soybean oil, oleic acid, glycerin, and the softgel capsule itself. If you have a soy allergy, check with your pharmacist, since this product contains soy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidyl Serine with SerinAid 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidyl Serine with SerinAid 100 mg label
Go deeper

The Full Monographs Behind Phosphatidyl Serine with SerinAid 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Phosphatidyl Serine with SerinAid 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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