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Dietary supplement

Beta-Carotene 25,000 IU Ingredients & Drug Interactions

by Sundown Naturals

Beta-Carotene 25,000 IU label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Beta-Carotene 25,000 IU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Beta-Carotene 25,000 IU is a dietary supplement by Sundown Naturals with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 387 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Beta-Carotene 25,000 IU by Sundown Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Beta-Carotene 25,000 IU by Sundown Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Beta-Carotene 25,000 IU by Sundown Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin A, supplied as 25,000 IU of beta-carotene per softgel. Beta-carotene is a plant-derived precursor that your body converts to vitamin A as needed.

The softgel capsule itself is made from gelatin, soybean oil, vegetable glycerin, yellow beeswax, and soy lecithin — these are inactive ingredients that help deliver the vitamin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: vitamin A supplement.
  • We looked for evidence on: Vitamin A deficiency, Night vision, Cataracts, Corneal abrasion, Acne, Aging skin — and 4 related terms.
  • The strongest evidence on file: Vitamin A is rated "Effective" for Vitamin A deficiency (Natural Medicines).
  • Also on file: Vitamin A is rated "Possibly Effective" for Aging skin, Night vision, Wrinkled skin.
  • Also on file: Vitamin A is rated "Possibly Ineffective" for Melanoma.

Vitamin A is effective for treating vitamin A deficiency. The evidence also suggests it may be possibly effective for oral leukoplakia, aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia — though the data for those uses is less established than it is for deficiency.

If you're taking this for a specific condition beyond simple deficiency, talk it through with your doctor to see if the evidence supports it for your situation.

The evidence, ingredient by ingredient Vitamin A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally well tolerated at recommended doses, but it builds up in your body over time, so high doses can become toxic. Serious side effects from excess vitamin A are rare but can include liver damage, a condition called pseudotumor cerebri (swelling inside the skull), and in very high doses, even coma.

More common signs of taking too much vitamin A chronically include dry, peeling, or reddened skin; brittle nails; hair loss; and fatigue. During pregnancy, the facts note a split rating: recommended and dietary amounts are likely safe, but high-dose vitamin A supplements — especially in the form of retinol — may pose a risk and are possibly unsafe.

During breastfeeding, normal dietary and recommended supplement amounts are appropriate. Talk with your doctor or pharmacist before taking high-dose vitamin A if you are pregnant, nursing, or planning to become pregnant.

Side effects, ingredient by ingredient Vitamin A

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin A.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 388 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sundown Naturals Beta-Carotene, double-check with your doctor or pharmacist if you take retinoids (like tretinoin or isotretinoin) — this is a Major interaction. You should also confirm if you're on blood thinners such as warfarin, tetracycline antibiotics, or any drugs that can strain the liver, as these carry Moderate interactions with high-dose vitamin A.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This beta-carotene supplement works well if you're deficient in vitamin A, and the dose here (25,000 IU) is below the upper safe limit for most adults. But if you take retinoid medications, blood thinners, tetracycline antibiotics, or other drugs that affect the liver, you'll need to check with your doctor or pharmacist first — the interactions can be serious.

Pregnant and nursing women should also confirm with their healthcare provider that this dose is right for them.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beta-Carotene 25,000 IU, straight from the product label.

Brand Sundown Naturals
Barcode (UPC) 030768004590
Net contents 100 Softgel(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1108
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beta-Carotene 25,000 IU by Sundown Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
030768004590
IngredientAmount% DV
Vitamin A25000 IU500%

Other ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, yellow Beeswax, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

VITAMIN A SUPPLEMENT

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Precautions

KEEP OUT OF REACH OF CHILDREN. STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT. TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

Brand IP Statement(s)

2010

General Statements

GUARANTEED QUALITY LABORATORY TESTED

HIGHEST POTENCY

PLEASE RECYCLE

Promotes Eye & Immune Health*

Smart Facts Beta-Carotene promotes immune and antioxidant support.* Beta-Carotene helps fight cell-damaging free radicals in the body.* Free radicals can contribute to oxidative stress, which in turn may contribute to the premature aging of cells.* This provitamin A is part of the Carotenoid family and readily converts to Vitamin A in the system when needed.*

General

Prod. No. 45347 06E B1220 DAZ

Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULTS, TAKE ONE (1) SOFTGEL DAILY, PREFERABLY WITH A MEAL. As a reminder, discuss the supplements and medications you take with your health care providers.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Beta-Carotene 25,000 IU by Sundown Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Beta-Carotene 25,000 IU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Beta-Carotene 25,000 IU by Sundown Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Vitamin A

Interacts with
387 drugs
25000 IU per serving Form: Beta-Carotene

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beta-Carotene 25,000 IU by Sundown Naturals Drug Interactions

Want to check YOUR meds against Beta-Carotene 25,000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
387Drugs
9 Major 378 Moderate

Ingredients driving the most interactions

Vitamin A 387

Individual Drug Interactions

The ingredients in Beta-Carotene 25,000 IU interact with 387 drugs. Click any drug to see the details.

1 of the 1 ingredient in Beta-Carotene 25,000 IU interact with drugs. Each result below shows which ingredient is responsible. Vitamin A

Each ingredient & the kinds of drugs it affects

For each ingredient in Beta-Carotene 25,000 IU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Beta-Carotene 25,000 IU, from the product label.

Sundown Naturals

See all Sundown Naturals products
Web Address
www.sundownnaturals.com
Pharmacist Counseling Corner

Beta-Carotene 25,000 IU by Sundown Naturals: Common Questions

Does Beta-Carotene 25,000 IU by Sundown Naturals interact with any medications?
Yes. Based on its ingredients, Beta-Carotene 25,000 IU has a known interaction with 387 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beta-Carotene 25,000 IU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is beta-carotene, and why is it in here instead of vitamin A directly?
Beta-carotene is a plant-derived form of vitamin A that your body converts to vitamin A as you need it. It's gentler than taking retinol (straight vitamin A) because your body controls how much it converts, reducing the risk of excess buildup.
Is 25,000 IU safe for daily use?
Yes — 25,000 IU is below the tolerable upper limit of 10,000 IU per day for adults, though the facts caution that even within safe ranges, vitamin A builds up in your body over time. If you're taking it long-term or have liver disease or take certain medications, talk with your doctor about whether this dose is right for you.
Can I take this if I'm pregnant?
The facts show a split rating: normal dietary amounts and recommended supplement doses are likely safe in pregnancy, but high-dose vitamin A supplements may be risky. Since this is a supplement (not a food source), you should confirm with your doctor or midwife that this dose is safe for your pregnancy.
What are the most common side effects?
At recommended doses, serious side effects are rare. Chronic use of too much vitamin A can cause dry, peeling skin; hair loss; brittle nails; and fatigue. Acute overdose — especially in young children — can cause headache, dizziness, and blurred vision.
Does this help with skin aging or acne?
The evidence suggests vitamin A may be possibly effective for aging skin. For acne, the data here doesn't address that use — you'd want to ask your doctor whether this supplement or a prescription retinoid is right for you.
Are there any other ingredients I should know about?
The softgel contains soybean oil, soy lecithin, and gelatin along with the beta-carotene. If you have soy or gelatin allergies, check the label or ask your pharmacist whether this product is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beta-Carotene 25,000 IU label
Go deeper

The Full Monographs Behind Beta-Carotene 25,000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph →
Sources

Sources & How We Checked

Beta-Carotene 25,000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
  22. Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
  23. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
  24. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
  25. Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
  26. Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
  27. Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
  28. Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
  29. Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
  30. Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
  31. Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed

See these in context on the Vitamin A monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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