Betaine Plus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Betaine Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Betaine Plus is a dietary supplement by Physician's Preference with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are from 650 mg Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Betaine Plus by Physician's Preference
Ask about any prescription or over-the-counter medication and we check it for interactions with Betaine Plus by Physician's Preference — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Betaine Plus by Physician's Preference
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 2 of its 2 active ingredients.
- “Betaine” is listed as a grouped ingredient — the label gives one combined amount (496 mg) without saying how much of each component you get.
Only Minor-severity interactions are documented for these ingredients.
Why this rating?
- 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
- The most serious interaction on file is rated Minor.
- For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 2 of 2.
- General safety write-ups exist for 2 of 2.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Betaine Plus, straight from the product label.
| Brand | Physician's Preference |
|---|---|
| Barcode (UPC) | 811749010980 |
| Net contents | 100 Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Oct 25, 2013 |
| DSLD ID | 26843 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Betaine Plus by Physician's Preference, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pepsin | 140 mg | -- |
| from 650 mg Betaine HCl | 650 mg | -- |
| Betaine | 496 mg | -- |
Other ingredients: Cellulose, Gelatin, Vegetable Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Tamper resistant package, do not use if outer seal is missing.
KEEP OUT OF REACH OF CHILDREN.
General
Formula #80106/#2216806
Formulation
This product contains NO yeast, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.
General Statements
Daily Essentials
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 capsule daily with food or as directed by your healthcare professional.
Storage
For optimal storage conditions, store in a cool, dry place (59(0)-77(0)F/15(0)-25(0)C) (35-45% relative humidity)
Formula
(With HCl And Pepsin)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Betaine Plus by Physician's Preference label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Betaine Plus by Physician's Preference
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pepsin
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Pepsin monograph & interactionsBetaine
Other (inactive) ingredients: Cellulose, Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.
Betaine Plus by Physician's Preference Drug Interactions
Betaine Plus contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 36 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Betaine Plus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Betaine Plus interact with 36 drugs. Click any drug to see the details.
1 of the 2 ingredients in Betaine Plus interact with drugs. Each result below shows which ingredient is responsible. from 650 mg Betaine HCl
PantoprazolePantoloc, Protonix, Protonix IV
How Pantoprazole interacts with Betaine Plus — through 1 ingredient. Tap an ingredient for the detail:
From 650 Mg Betaine HclProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full From 650 Mg Betaine Hcl + Pantoprazole interactionRabeprazolePariet
How Rabeprazole interacts with Betaine Plus — through 1 ingredient. Tap an ingredient for the detail:
From 650 Mg Betaine HclProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full From 650 Mg Betaine Hcl + Rabeprazole interactionRabeprazole SodiumAciphex, Aciphex Sprinkle
How Rabeprazole Sodium interacts with Betaine Plus — through 1 ingredient. Tap an ingredient for the detail:
From 650 Mg Betaine HclProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full From 650 Mg Betaine Hcl + Rabeprazole Sodium interactionRanitidineRanit, Ranitidine injection, Zantac, Zantac 150, Zantac 150 EFFER, Zantac 150 GEL +4 more
How Ranitidine interacts with Betaine Plus — through 1 ingredient. Tap an ingredient for the detail:
From 650 Mg Betaine HclH2-blockers Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
Read the full From 650 Mg Betaine Hcl + Ranitidine interactionRanitidine Bismuth CitrateTritec
How Ranitidine Bismuth Citrate interacts with Betaine Plus — through 1 ingredient. Tap an ingredient for the detail:
From 650 Mg Betaine HclH2-blockers Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
Read the full From 650 Mg Betaine Hcl + Ranitidine Bismuth Citrate interactionSodium Bicarbonate (otc Drug)Sodium Bicarbonate
How Sodium Bicarbonate (otc Drug) interacts with Betaine Plus — through 1 ingredient. Tap an ingredient for the detail:
From 650 Mg Betaine HclAntacids Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
Read the full From 650 Mg Betaine Hcl + Sodium Bicarbonate (otc Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Betaine Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
from 650 mg Betaine HCl
Antacids
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.
H2-Blockers
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.
Proton Pump Inhibitors (Ppis)
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs
Brand information
Manufacturer and brand details for Betaine Plus, from the product label.
Physician's Preference
See all Physician's Preference products- Name
- Physician's Preference(R)
- Street Address
- 20214 Braidwood Dr., Ste. 160
- City
- Katy
- State
- TX
- ZipCode
- 77450
- Web Address
- www.physicianspreference.com
Betaine Plus by Physician's Preference: Common Questions
Does Betaine Plus by Physician's Preference interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Betaine Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Betaine Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographBetaine Hydrochloride
Interacts with 36 drugsBetaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...
Read the full Betaine Hydrochloride monograph →Sources & How We Checked
Betaine Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Betaine Hydrochloride 2 references
- Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
- Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed
See these in context on the Betaine Hydrochloride monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC