Major interaction on record — check this product against your medications before combining. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Bio-Gro Unflavored Ingredients & Drug Interactions

by iSatori

Bio-Gro Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio-Gro Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Bio-Gro Unflavored is a dietary supplement by iSatori with 7 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 168 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bio-Gro Unflavored by iSatori

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio-Gro Unflavored by iSatori — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bio-Gro Unflavored by iSatori

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Custom Engineered Bio-Pro Bio-Active Peptides” is listed as a grouped ingredient — the label gives one combined amount (1.50 Gram(s)) without saying how much of each component you get.

Bio-Gro Unflavored contains 6 active ingredients. Calcium is the primary mineral component, included for bone health and other roles.

The product also contains proline-rich peptides (amino acids tied to connective tissue), lactoferrin (a protein that binds and transports iron), fibroblast growth factor, a proprietary blend of growth factors, and immunoglobulins (immune proteins). The inactive ingredients are medium-chain triglycerides and sunflower lecithin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hyperkalemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Dyspepsia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Kidney failure — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hypocalcemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Osteoporosis — rated "Likely Effective" (Calcium) (Natural Medicines).

Calcium in this product is effective for kidney failure, indigestion, low blood calcium (hypocalcemia), high potassium (hyperkalemia), and likely effective for osteoporosis. For the other active ingredients, the evidence is less clear.

Proline-rich peptides, lactoferrin, and the growth factor blends all have insufficient reliable evidence to rate them for athletic performance, fractures, bone loss (osteopenia), osteoporosis, or wound healing. Lactoferrin appears possibly effective for blood infection (sepsis) and pregnancy-related iron deficiency, but likely ineffective for preventing harm to newborns.

The evidence, ingredient by ingredient Calcium Proline Lactoferrin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems. Common mild side effects from oral calcium are belching, constipation, diarrhea, gas, and stomach upset.

Rare serious concerns include kidney stones and a skin condition called calciphylaxis. There is also some concern that very high calcium intake — over 1,500–2,000 mg daily — may be linked to increased prostate cancer risk and possibly cardiovascular disease, though research on this remains mixed and debated.

Proline-rich peptides are considered low-risk from food sources, but supplement safety hasn't been well studied. Lactoferrin is generally well tolerated short-term; at higher doses (7.2 grams daily) constipation, diarrhea, and fatigue have been reported.

Long-term safety data for lactoferrin are limited.

Side effects, ingredient by ingredient Calcium Proline Lactoferrin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 168 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any HIV integrase inhibitors (dolutegravir, elvitegravir, or raltegravir), thyroid medication (levothyroxine), heart drugs (diltiazem, sotalol), the antibiotic ceftriaxone, or psoriasis treatments like calcipotriene, you need to discuss this product with your pharmacist or doctor before starting — calcium can significantly affect how these work. Timing and separation of doses matter.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This is a calcium-based product suited for bone health and related deficiencies, but its main ingredient interacts with several important drug classes — especially HIV medications and thyroid drugs. If you take prescriptions, check them against this product before use.

Proline-rich peptides and lactoferrin are generally well tolerated but lack strong evidence for many claims. Talk with your pharmacist about your specific medications and health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio-Gro Unflavored, straight from the product label.

Brand iSatori
Barcode (UPC) 883488003370
Net contents 3.17 oz.; 90 Gram(s)
Market status On market
Date entered into DSLD Jan 25, 2016
DSLD ID 56091
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio-Gro Unflavored by iSatori, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
4.5 Gram(s)
Servings per container
60
UPC/BARCODE
883488003370
IngredientAmount% DV
Calories5 {Calories}--
Total Carbohydrates1 Gram(s)1%
Sugar0 Gram(s)--
Calcium20 mg2%
proline rich Peptides0 NP--
Lactoferrin0 NP--
Fibroblast-GF0 NP--
Growth Factors0 NP--
Immunoglobulins0 NP--
Custom Engineered Bio-Pro Bio-Active Peptides1.5 Gram(s)--

Other ingredients: Medium Chain Triglycerides, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Consult a physician or healthcare provider before using this or any other dietary supplement or starting any exercise program. WARNING for California residents only: This product contains substances known to the state of California to cause cancer and birth defects and other reproductive harm. Exposure to moisture and humidity may cause clumping but will not affect product efficacy. Do not use if packaging has been tampered with.

NOTICE: TESTED ATHLETES SHOULD CHECK WITH GOVERNING BODY(s) BEFORE USE.

ALLERGEN WARNING: Contains milk product (Colostrum).

WARNING: KEEP OUT OF REACH OF CHILDREN.

Do not use this product if you are pregnant, nursing, or contemplating pregnancy.

Not intended for individuals under the age of 18, unless instructed by a doctor.

Storage

Store in a cool, dry place between 60(0) F and 80(0) F.

Seals/Symbols

MADE IN THE USA

MANUFACUTRED IN A GMP FACILITY

General Statements

Made in the USA in a GMP Facility.

(Stock Symbol: “IFIT”)

PATENT-PENDING. USPTO No. 61/832,610

Bio-Pro Bio-Active Peptides (BAP’s) are cleaved protein fragments extracted from the highest grade bovine colostrum.

For scientific references and clinical study results, visit iSatori.com/BioGro

INSTANTIZED EASY MIXING!

Get Your FREE Hyper-Growth Training Plan, Visit TheMuscleSystem.com or call 1-866-688-7679

PROTEIN SYNTHESIS AMPLIFIER

DELICIOUS

If you, or your doctor, have any questions about this product, please call 1-866-688-7679.

Brand IP Statement(s)

2014 iSatori, Inc.,

POWERED BY Bio Pro Bio-Active Peptides

General

060114

Formula

The first ever to utilize a highly concentrated, patented form of micro-fraction BAP’s, Bio-Gro signals the body to amplify the natural protein synthesis process, helping you develop lean muscle more efficiently and recover faster from intense workouts.

Contains milk product (Colostrum).

Suggested/Recommended/Usage/Directions

DAILY USAGE To best amplify protein synthesis, use Bio-Gro twice daily as follows: BODYWEIGHT <200 lbs >200 lbs AM 2 {scoops} / 3 {scoops} PM 2 {scoops} / 3 {scoops}

DIRECTIONS FOR USE: As a dietary supplement, mix 2 to 3 servings (heaping scoops) of Bio-Gro twice daily in 6 to 9 oz of cold liquid, or mix in soft food (yogurt, oatmeal, protein shake, etc.). Bio-Gro is available as an unflavored or flavored powder that can be taken anytime with or without food. Follow daily usage chart for optimal results (on left panel).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio-Gro Unflavored by iSatori label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio-Gro Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio-Gro Unflavored by iSatori

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

Calcium

Interacts with
168 drugs
20 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Custom Engineered Bio-Pro Bio-Active Peptides

1.5 Gram(s) per serving Form: Colostrum

Other (inactive) ingredients: Medium Chain Triglycerides, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio-Gro Unflavored by iSatori Drug Interactions

Want to check YOUR meds against Bio-Gro Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
168Drugs
7 Major 143 Moderate 18 Minor

Ingredients driving the most interactions

Calcium 168

Individual Drug Interactions

The ingredients in Bio-Gro Unflavored interact with 168 drugs. Click any drug to see the details.

1 of the 7 ingredients in Bio-Gro Unflavored interact with drugs. Each result below shows which ingredient is responsible. Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio-Gro Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio-Gro Unflavored, from the product label.

iSatori

See all iSatori products
Name
iSatori
Street Address
15000 W. 6th Ave., Ste. 202
City
Golden
State
CO
ZipCode
80401
Phone Number
1-866-688-7679
Web Address
www.iSatori.com
Pharmacist Counseling Corner

Bio-Gro Unflavored by iSatori: Common Questions

Does Bio-Gro Unflavored by iSatori interact with any medications?
Yes. Based on its ingredients, Bio-Gro Unflavored has a known interaction with 168 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio-Gro Unflavored contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
Calcium is likely safe in pregnancy at recommended amounts — adequate calcium is actually important during pregnancy. However, proline-rich peptides and lactoferrin don't have enough safety data established for pregnancy, so the supplement as a whole should only be used under medical supervision. Talk with your doctor before starting.
Can I take this while breastfeeding?
Calcium needs can be met during breastfeeding at recommended amounts. Lactoferrin occurs naturally in breast milk, but safety of the supplement form while breastfeeding isn't well studied. Proline-rich peptides also lack established breastfeeding safety data. Check with your provider before use.
What are the most common side effects?
From calcium, the most likely mild side effects are constipation, diarrhea, belching, gas, and stomach upset. Lactoferrin can cause constipation or diarrhea, especially at higher doses. Most people tolerate it well at typical doses.
Does proline-rich peptides actually help with bone health or fractures?
There isn't enough reliable evidence yet to say whether it works for bone health, fractures, or osteoporosis. The calcium in the formula is the ingredient with solid evidence for bone support.
What is lactoferrin and why is it in here?
Lactoferrin is a protein that carries iron. It's naturally in breast milk and other body fluids. It appears possibly effective for blood infection (sepsis) and pregnancy-related low iron, but it's likely ineffective at preventing serious newborn complications. It's included here as a general wellness ingredient.
Why can't you check some ingredients for drug interactions?
Fibroblast growth factor, growth factors, immunoglobulins, and the custom peptide blend don't have interaction data on file — we simply don't hold a detailed monograph for them. That doesn't mean they don't interact; it means we haven't checked them yet. If those are concerns for you, ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio-Gro Unflavored label
Go deeper

The Full Monographs Behind Bio-Gro Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Proline

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...

Read the full Proline monograph → Herb & supplement monograph

Lactoferrin

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is being studied for immune support, iron l...

Read the full Lactoferrin monograph →
Sources

Sources & How We Checked

Bio-Gro Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 72 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
  23. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
  24. Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-6. PubMed
  25. Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed
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See these in context on the Lactoferrin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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