Biodynamic Organic Pomegranate Peel Ingredients & Drug Interactions
by Dr. Mercola
What is this page for?
First and foremost: checking Biodynamic Organic Pomegranate Peel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Biodynamic Organic Pomegranate Peel is a dietary supplement by Dr. Mercola with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Biodynamic organic Pomegranate peel powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Biodynamic Organic Pomegranate Peel by Dr. Mercola
Ask about any prescription or over-the-counter medication and we check it for interactions with Biodynamic Organic Pomegranate Peel by Dr. Mercola — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Biodynamic Organic Pomegranate Peel by Dr. Mercola
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains a single active ingredient: biodynamic organic pomegranate peel powder. Pomegranate peel is the outer skin of the pomegranate fruit, dried and powdered.
The inactive ingredients are organic gum acacia and tapioca maltodextrin, which are binders and fillers that hold the tablet together.
Does it work?
Moderate evidence
Pomegranate peel is possibly effective for high blood pressure — some research shows it may help lower it modestly. For high cholesterol and diabetes, the evidence rates as possibly ineffective.
For nonalcoholic fatty liver disease, we don't have enough reliable evidence to rate it either way. If you're considering this for blood pressure support, talk with your doctor about whether it fits your treatment plan.
How safe is it?
Well-documented data
Pomegranate fruit and juice are generally well tolerated as food. However, because this is a concentrated peel supplement rather than whole fruit, the safety data is more limited.
The main mild side effects reported are diarrhea and flatulence — in clinical studies, these occurred in a small number of people taking pomegranate extracts. Nausea, abdominal pain, and constipation have also been reported in small numbers of trial participants at higher doses.
For pregnancy and lactation, the available data rates pomegranate as possibly safe, though information is limited. If you're pregnant or nursing, talk with your doctor or pharmacist before starting this supplement to weigh the benefits and unknowns for your situation.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take blood pressure-lowering drugs (antihypertensives), ACE inhibitors, warfarin or other blood thinners, rosuvastatin or other cholesterol medications, or any drug your liver processes through CYP2D6 enzymes — these carry documented moderate-severity interactions. Minor interactions are also documented with CYP2C9 and CYP3A4 substrate drugs and carbamazepine.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Pomegranate peel may help with blood pressure, though the evidence is modest. If you take blood pressure drugs, blood thinners, cholesterol medications, or drugs your liver metabolizes through certain pathways, you'll need to check your exact medications with your doctor or pharmacist first — this supplement has documented interactions with a wide range of drugs.
Generally well tolerated, but mild digestive side effects are possible. Discuss it with your healthcare provider before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Biodynamic Organic Pomegranate Peel, straight from the product label.
| Brand | Dr. Mercola |
|---|---|
| Barcode (UPC) | 810487033626 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2021 |
| DSLD ID | 250386 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Biodynamic Organic Pomegranate Peel by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Biodynamic organic Pomegranate peel powder | 750 mg | -- |
Other ingredients: organic Gum Acacia, Tapioca Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Adults, as a dietary supplement, take two (2) tablets daily, preferably on an empty stomach.
Keep out of reach of children.
Precautions
Do not use if safety seal is broken.
If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.
General Statements
Dr. Mercola has been providing quality products since 2001.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Demeter Certified Biodynamic USDA Organic
Formulation
USDA Organic Certified Organic by: QCS
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Biodynamic Organic Pomegranate Peel by Dr. Mercola label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Biodynamic Organic Pomegranate Peel by Dr. Mercola
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Biodynamic organic Pomegranate peel powder
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Biodynamic organic Pomegranate peel powder monograph & interactionsOther (inactive) ingredients: Organic Gum Acacia, Tapioca Maltodextrin. These complete the product’s ingredient list but are not active constituents.
Biodynamic Organic Pomegranate Peel by Dr. Mercola Drug Interactions
HelloPharmacist Interaction Report
Dr.
Mercola's Biodynamic Organic Pomegranate Peel contains one active ingredient — pomegranate peel powder — which interacts with several medication types. The most serious concern is with blood pressure-lowering drugs (antihypertensives).
Pomegranate can lower blood pressure on its own, so combining it with these medications might push your pressure too low.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to flag ACE inhibitors (a common blood pressure med), warfarin (a blood thinner), and drugs your liver breaks down using specific enzymes — particularly CYP2D6 substrates and rosuvastatin (a cholesterol medication). Pomegranate may raise levels of these drugs in your bloodstream, raising the risk of side effects.
With warfarin specifically, there's also a theoretical bleeding risk. Minor interactions are documented with other liver-enzyme-processed drugs (CYP2C9 and CYP3A4 substrates) and carbamazepine (an anti-seizure medication), though research suggests these are less likely to cause real-world problems.
We could not check a couple of inactive ingredients for interaction data. Altogether, these interactions span 923 individual medications.
Use the medication checker on this page to see if any of your prescriptions are affected, and go over the results with your doctor or pharmacist before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Biodynamic Organic Pomegranate Peel?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Biodynamic Organic Pomegranate Peel interact with 922 drugs. Click any drug to see the details.
1 of the 1 ingredient in Biodynamic Organic Pomegranate Peel interact with drugs. Each result below shows which ingredient is responsible. Biodynamic organic Pomegranate peel powder
AcebutololRhotral, Sectral
How Acebutolol interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acebutolol interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Hydrocodone interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Oxycodone interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Biodynamic Organic Pomegranate Peel — through 1 ingredient. Tap an ingredient for the detail:
Biodynamic Organic Pomegranate Peel PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Biodynamic Organic Pomegranate Peel Powder + Acetazolamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Biodynamic Organic Pomegranate Peel with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Biodynamic organic Pomegranate peel powder
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Brand information
Manufacturer and brand details for Biodynamic Organic Pomegranate Peel, from the product label.
Dr. Mercola
See all Dr. Mercola products- Name
- NHP
- Street Address
- 125 SW 3rd Place
- City
- Cape Coral
- State
- FL
- ZipCode
- 33991
- Phone Number
- (877) 985-2696
Biodynamic Organic Pomegranate Peel by Dr. Mercola: Common Questions
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The Full Monographs Behind Biodynamic Organic Pomegranate Peel’s Ingredients
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Sources & How We Checked
Biodynamic Organic Pomegranate Peel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pomegranate 27 references
- Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
- Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
- Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
- Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
- Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
- Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
- Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
- Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
- Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
- Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
- Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
- Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
- Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
- Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
- Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. PubMed
- Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2.
- Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther PubMed
- Jarvis S, Li C, Bogle RG. Possible interaction between pomegranate juice and warfarin. Emerg Med J 2010;27:74-5. PubMed
- Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., and Azadbakht, L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam.Nutr Res 2006;76(3):147-151. PubMed
- Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study PubMed
- Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.
- Sohrab G, Sotoodeh G, Siasi F, et al. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470.
- Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. PubMed
- Hanley MJ, Masse G, Harmatz JS, et al. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results. Clin Pharmacol Ther 2012;92(5):651-7. PubMed
- Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5. PubMed
- Park SJ, Yeo CW, Shim EJ, et al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. PubMed
- Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC