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Dietary supplement

Pau D'Arco 1,000 mg Ingredients & Drug Interactions

by Dr. Mercola

Pau D'Arco 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco 1,000 mg is a dietary supplement by Dr. Mercola with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco 1,000 mg by Dr. Mercola

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco 1,000 mg by Dr. Mercola — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco 1,000 mg by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco (also called pau d'arco bark), at 1,000 mg per capsule. Pau d'arco is a tree bark traditionally used in South American herbal medicine.

The capsule itself is made from inactive ingredients including hydroxypropyl methylcellulose (a plant-based capsule material), microcrystalline cellulose, medium chain triglyceride, and rice husk.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that pau d'arco works for any of its traditional uses. The data shows insufficient reliable evidence to rate it for cancer, peptic ulcers, wound healing, or dysmenorrhea (painful periods).

That doesn't mean it doesn't work—it means the studies aren't there yet to prove it does. If you're considering it for a specific condition, talk with your doctor about what the science actually supports.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at lower doses, but the safety data we hold flags several concerns. At doses above 1.5 grams of lapachol daily, it may cause anemia (low red blood cells), severe nausea, vomiting, diarrhea, and increased bleeding risk.

The product label advises caution because human safety data is limited. Occupational exposure to pau d'arco sawdust can cause asthma and skin reactions, though that's mainly a risk for workers, not supplement users.

The safety data advises against use during pregnancy due to possible harm to a developing baby and lack of safety studies. There isn't enough safety data to know whether it's okay while breastfeeding, so talk with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs—such as warfarin, apixaban, rivaroxaban, aspirin, clopidogrel, or dabigatran—talk with your doctor or pharmacist before starting this product. Pau d'arco may increase your bleeding risk when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'Arco 1,000 mg is a single-ingredient supplement made from pau d'arco bark—a traditional remedy with limited evidence of effectiveness for its claimed uses. The main concern is interaction with blood thinners and clot-preventing drugs, which can raise bleeding risk.

It's not recommended in pregnancy or while breastfeeding. Before you start, check your medications with your doctor or pharmacist, especially if you take any anticoagulants or antiplatelet drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco 1,000 mg, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810487031899
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 308861
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco 1,000 mg by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
810487031899
IngredientAmount% DV
Pau d'Arco1000 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Medium Chain Triglyceride, Rice Husk

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults, as a dietary supplement, take two (2) capsules twice daily.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, have a blood coagulation or other medical condition, or are taking medication such as anticoagulants, consult your physician before taking this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Blood flow support Energy production Mitochondrial health

FDA Statement of Identity

Dietary Supplement

General Statements

Providing quality products since 2001.

Formula

Pau D'Arco 1,000 mg per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco 1,000 mg by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco 1,000 mg by Dr. Mercola

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Pau d'Arco

Interacts with
122 drugs
1000 mg per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Medium Chain Triglyceride, Rice Husk. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco 1,000 mg by Dr. Mercola Drug Interactions

Want to check YOUR meds against Pau D'Arco 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco 122

Individual Drug Interactions

The ingredients in Pau D'Arco 1,000 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco 1,000 mg, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Pau D'Arco 1,000 mg by Dr. Mercola: Common Questions

Does Pau D'Arco 1,000 mg by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Pau D'Arco 1,000 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pau D'Arco if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy due to possible harm to a developing baby. There also isn't enough safety information available to recommend it while breastfeeding. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing.
Does Pau D'Arco work for cancer, ulcers, or wound healing?
The evidence we hold shows insufficient reliable evidence to rate pau d'arco for cancer, peptic ulcers, wound healing, or dysmenorrhea. That means the research isn't there yet to prove it works for these uses. If you're considering it for a specific condition, discuss what the evidence actually supports with your doctor.
What side effects might I experience?
At higher doses—above 1.5 grams of the lapachol compound daily—pau d'arco may cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea. Human safety data is limited, so caution is advised. If you notice any unusual symptoms, stop and talk with your pharmacist or doctor.
Is this safe to take with my blood thinner?
No, not without checking first. Pau d'arco may increase your bleeding risk if you take anticoagulant or antiplatelet drugs like warfarin, aspirin, or clopidogrel. Talk with your doctor or pharmacist before adding this to your routine.
How much pau d'arco is in each capsule?
Each capsule contains 1,000 mg of pau d'arco bark. The inactive ingredients are hydroxypropyl methylcellulose, microcrystalline cellulose, medium chain triglyceride, and rice husk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco 1,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco 1,000 mg label
Go deeper

The Full Monographs Behind Pau D'Arco 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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