No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Biotin 1000 mcg Ingredients & Drug Interactions

by Nature Made

Biotin 1000 mcg label
See full label image
Softgel Capsule Category: Vitamin
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biotin 1000 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Biotin 1000 mcg is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Biotin 1000 mcg by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: biotin, a B vitamin (B7) that supports hair, skin, and nail health, and plays a role in how your body metabolizes carbohydrates and fats. The inactive ingredients are soybean oil, gelatin, glycerin, yellow beeswax, water, rapeseed lecithin, and added colors—typical softgel capsule materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Biotin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports nervous system function.
  • We looked for evidence on: Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Biotin-thiamine-responsive basal ganglia disease, Diabetic neuropathy, Multiple sclerosis (MS), Muscle cramps, neuropathy — and 1 related terms.
  • The closest evidence on file: Biotin is rated "Possibly Ineffective" for Multiple sclerosis (MS) (Natural Medicines).
  • Also on file: Biotin is rated "Insufficient Reliable Evidence To Rate" for Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Diabetic neuropathy, Muscle cramps, Biotin-thiamine-responsive basal ganglia disease.

Biotin is likely effective for biotin deficiency, which is rare but can happen with certain conditions or medications. For other uses listed on the label—multiple sclerosis, seborrheic dermatitis (a red, flaky scalp condition), and hair loss (alopecia areata)—the evidence is either possibly ineffective or too thin to rate.

Talk with your doctor about whether this dose makes sense for your specific situation.

The evidence, ingredient by ingredient Biotin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at higher doses, because your body clears excess amounts through urine. Mild diarrhea has rarely been reported with very high doses (300 mg daily is far above this product's 1 mg dose).

One isolated case report linked high-dose biotin plus other supplements to a rare inflammation, but whether biotin was actually the cause remains unclear. Normal dietary amounts and typical supplement doses are considered safe, but if you're thinking about taking high-dose biotin products, check with your doctor first.

Side effects, ingredient by ingredient Biotin

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for the ingredients we could check in this product.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This supplement is straightforward if you have a biotin deficiency or want to cover your daily B7 needs. If you're taking it for hair, skin, or nail appearance without a known deficiency, the evidence doesn't strongly support it working for those goals.

There are no documented interactions with medications, but it's always smart to mention any new supplement to your doctor or pharmacist, especially if you're pregnant, breastfeeding, or considering high doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biotin 1000 mcg, straight from the product label.

Brand Nature Made
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270954
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biotin 1000 mcg by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
IngredientAmount% DV
Biotin1000 mcg3333%

Other ingredients: Soybean Oil, Gelatin, Glycerin, yellow Beeswax, Water, Rapeseed Lecithin, Colors added

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#1 pharmacist recommended Vitamin & supplement brand

Seals/Symbols

USP Verified Dietary Supplement

Formulation

Helps support nervous system function Essential nutrient

No synthetic dyes - colors derived from natural sources No artificial flavors Gluten free

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org Based on Pharmacy Times survey of pharmacists recommending letter vitamin supplements.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take 1 softgel daily with water and a meal.

Storage

Store tightly closed, in a cool, dry place, out of reach of children.

Precautions

Do not use if imprinted seal under cap is broken or missing.

Caution: Biotin may interfere with lab tests.

If you are taking medication or planning to undergo lab testing, consult your physician before use.

Store tightly closed, in a cool, dry place, out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biotin 1000 mcg by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biotin 1000 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biotin 1000 mcg by Nature Made

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Biotin

No known
interactions
1000 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Yellow Beeswax, Water, Rapeseed Lecithin, Colors added. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biotin 1000 mcg by Nature Made Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Biotin 1000 mcg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Biotin 1000 mcg, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
West Hills
State
CA
ZipCode
91309-9903
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

Biotin 1000 mcg by Nature Made: Common Questions

Does Biotin 1000 mcg by Nature Made interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Biotin 1000 mcg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Biotin 1000 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is biotin safe during pregnancy or breastfeeding?
Yes—biotin is rated likely safe in pregnancy and lactation. That said, amounts from food and standard prenatal vitamins are what's been established as appropriate. If you're considering a separate high-dose supplement, check with your doctor or midwife first.
Will biotin help my hair, skin, or nails grow?
The evidence is mixed. Biotin is likely effective only if you actually have a biotin deficiency, which is uncommon. For general hair, skin, or nail health without a deficiency, the science doesn't show it works reliably. Your doctor can tell you whether you're deficient.
What does biotin actually do in the body?
Biotin is a B vitamin that helps your body convert food into energy and plays a role in keeping hair, skin, and nails healthy. You get some from food, but this supplement adds extra if you're not getting enough from your diet.
Can I take this if I have a medical condition?
Biotin itself has no documented interactions with medications, but it's worth mentioning to your doctor or pharmacist if you have a chronic condition or take regular prescriptions—they know your full picture and can advise.
Are there any side effects at this dose?
At 1000 mcg, side effects are unlikely. Mild diarrhea has been rarely reported only with very high doses (300 mg daily or higher). This product is well below that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Biotin 1000 mcg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biotin 1000 mcg label
Go deeper

The Full Monographs Behind Biotin 1000 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph →
Sources

Sources & How We Checked

Biotin 1000 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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