Black Elderberry Syrup Ingredients & Drug Interactions
by Sambucol
What is this page for?
First and foremost: checking Black Elderberry Syrup against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Black Elderberry Syrup is a dietary supplement by Sambucol with 2 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Elderberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Black Elderberry Syrup by Sambucol
Ask about any prescription or over-the-counter medication and we check it for interactions with Black Elderberry Syrup by Sambucol — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Black Elderberry Syrup by Sambucol
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — Elderberry.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
- For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Black Elderberry Syrup, straight from the product label.
| Brand | Sambucol |
|---|---|
| Net contents | 7.8 Fluid Ounce(s); 230 mL |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 245370 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Black Elderberry Syrup by Sambucol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 30 Calorie(s) | -- |
| Total Carbohydrates | 8 Gram(s) | 3% |
| Sugar | 8 Gram(s) | -- |
| Elderberry extract | 3.8 Gram(s) | -- |
Other ingredients: Glucose Syrup, purified Water, Citric Acid, Potassium Sorbate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
BDP K Kosher: Supervised by the Chief Rabbinate of BETH DIN DE PARIS
Formula
BDP K Kosher: Supervised by the Chief Rabbinate of BETH DIN DE PARIS
Suggested/Recommended/Usage/Directions
Directions for use: For daily maintenance: Adults and children over 4 years: Take 2 teaspoons (10 ml) daily. For intensive use: Adults and children over 4 years: Take 2 teaspoons (10 ml) four times daily. If desired, mix syrup in water, fruit juice, smoothies, yogurt, or most anything!
Precautions
Sealed for your protection. Do not use if seal is broken or missing.
Keep out of reach of children.
Product of France
Storage
To preserve quality and freshness, keep tightly sealed and keep in a cool, dry place.
Formulation
Free from gluten, dairy, soy, wheat, nuts, artificial color and flavors.
Gluten free
Great tasting syrup Scientifically tested Supports immunity High antioxidant levels Syrup
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Black Elderberry Syrup by Sambucol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Black Elderberry Syrup by Sambucol
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size10 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Elderberry extract
Interacts with121 drugs
Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...
Elderberry extract monograph & interactionsOther (inactive) ingredients: Glucose Syrup, Purified Water, Citric Acid, Potassium Sorbate. These complete the product’s ingredient list but are not active constituents.
Black Elderberry Syrup by Sambucol Drug Interactions
Black Elderberry Syrup contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 121 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Black Elderberry Syrup?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Black Elderberry Syrup interact with 121 drugs. Click any drug to see the details.
1 of the 2 ingredients in Black Elderberry Syrup interact with drugs. Each result below shows which ingredient is responsible. Elderberry extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Abrocitinib interactionAdalimumabHumira
How Adalimumab interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Adalimumab-fkjp interactionAlefaceptAmevive
How Alefacept interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Alemtuzumab interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Anifrolumab-fnia interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Antithymocyte Globulin interactionAtezolizumabTecentriq
How Atezolizumab interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Azathioprine interactionBasiliximabSimulect
How Basiliximab interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Basiliximab interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Beclomethasone Dipropionate interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Betamethasone Valerate interactionBimekizumab-bkzxBimzelx
How Bimekizumab-bkzx interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Bimekizumab-bkzx interactionCiclesonideAlvesco, Omnaris, Zetonna
How Ciclesonide interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Ciclesonide interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Cisplatin interactionCladribineLeustatin, Mavenclad
How Cladribine interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Cladribine interactionCopanlisibAliqopa
How Copanlisib interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Copanlisib interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Black Elderberry Syrup — through 1 ingredient. Tap an ingredient for the detail:
Elderberry ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry Extract + Cortisone Acetate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Black Elderberry Syrup with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Elderberry extract
Immunosuppressants
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.
Pazopanib (Votrient)
Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
Brand information
Manufacturer and brand details for Black Elderberry Syrup, from the product label.
Sambucol
See all Sambucol products- Name
- PharmaCare US, Inc.
- City
- San Diego
- State
- CA
- ZipCode
- 92108
- Phone Number
- 1-888-871-9098
- Web Address
- www.SambucolUSA.com
Black Elderberry Syrup by Sambucol: Common Questions
Does Black Elderberry Syrup by Sambucol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Black Elderberry Syrup is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Black Elderberry Syrup’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Black Elderberry Syrup's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Elderberry 6 references
- Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
- Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
- European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
- Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
- Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
- Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC