Brazil Red Bee Propolis Capsules Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Brazil Red Bee Propolis Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Brazil Red Bee Propolis Capsules is a dietary supplement by Confidence USA with 2 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bee Propolis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Brazil Red Bee Propolis Capsules by Confidence USA
Ask about any prescription or over-the-counter medication and we check it for interactions with Brazil Red Bee Propolis Capsules by Confidence USA — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Brazil Red Bee Propolis Capsules by Confidence USA
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Brazil Red Bee Propolis Capsules contains 2 active ingredients: bee propolis and Brazil bee propolis extract. Propolis is a resinous compound that honey bees make and use to seal their hives.
Both forms in this product are the same active ingredient from the monograph, just listed separately—you're getting propolis as the therapeutic agent. The capsule itself contains inactive ingredients: bovine gelatin (the capsule material), rice flour, microcrystalline cellulose, and magnesium stearate (a binder and flow agent).
Does it work?
Moderate evidence
The evidence on propolis is mixed. For oral mucositis (mouth inflammation from chemotherapy or other causes) and herpes labialis (cold sores), the data we hold rates it as possibly effective—meaning there's some promising research, but it's not yet rock-solid.
For diabetes, propolis is also rated possibly effective on the same basis. For dengue fever, we don't have enough reliable evidence to say one way or the other.
Talk to your pharmacist or doctor about whether this product fits your needs.
How safe is it?
Well-documented data
Propolis is generally well tolerated in the short term. The most common side effect is headache—about 7% of people taking 250 mg twice daily for 4 months reported mild headache in one trial.
Allergic reactions are possible, especially if you're sensitive to bee products. Serious allergic reactions are rare but can happen.
If you're allergic to bees or bee products, be cautious. Because there isn't enough reliable safety data, the product should be avoided during pregnancy and while breastfeeding.
Meds to double-check
Moderate interaction found
Check the following medication types before adding this product: drugs metabolized by CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2E1 (your pharmacist can tell you if yours fall into these groups), blood thinners and antiplatelet drugs, and warfarin in particular. All carry a Moderate severity rating.
Use the search tool above to verify your exact medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you have no allergies to bee products and aren't on medications that depend on liver enzymes to be cleared, this propolis supplement may be worth a try for cold sores, mouth inflammation, or blood sugar support. Steer clear if you're pregnant, breastfeeding, or allergic to bee products.
Before you start, run your medications through the interaction checker on this page—propolis affects how your body processes many drugs.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Brazil Red Bee Propolis Capsules, straight from the product label.
| Brand | Confidence USA |
|---|---|
| Barcode (UPC) | 892483001755 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2023 |
| DSLD ID | 283347 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Brazil Red Bee Propolis Capsules by Confidence USA, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bee Propolis | 0 NP | -- |
| Brazil Red Proprietary Blend | 800 mg | -- |
| Brazil Bee Propolis Extract | 0 NP | -- |
Other ingredients: Bovine Gelatin, Rice Flour, Microcrystalline Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: If you are pregnant, nursing or taking any medications, consult your physician before using this product.
Discontinue use and contact your physician if any adverse reactions occur.
Keep out of reach of children.
If outer safety seal is broken or missing, do not consume.
Formula
Brazil Red - Bee Propolis Capsules is a 100% natural pure Brazilian Bee Propolis extract that contains up to 400% more bee propolis than other bee propolis products on the market.
High quality propolis
Formulation
Research has shown that Brazilian Bee Propolis is the most highly desired and concentrated variety of bee propolis due to the local climate and vegetation. When taken regularly, Brazilian Bee Propolis may support immunity, cellular proliferation, detoxification and anti-aging.
Brazil Red - Bee Propolis Capsules is manufactured by Confidence USA, Inc., an FDA registered manufacturer following strict current Good Manufacturing Practices. (FDA Registration# 10362791850 - Product Code# FP0193)
Made in USA
Supports overall health
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Good Manufacturing Practice GMP
100% Potency guaranteed
General Statements
Other countries: 001-516-767-1860 For more info and reorders: www.ConfidenceUSA.com
Brand IP Statement(s)
Confidence USA Better Products for A Better Life
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adult - Take 2 capsules daily as dietary supplement.
Storage
Store at room temperature, with lid tightly closed.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Brazil Red Bee Propolis Capsules by Confidence USA label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Brazil Red Bee Propolis Capsules by Confidence USA
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Brazil Red Proprietary Blend
Other (inactive) ingredients: Bovine Gelatin, Rice Flour, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Brazil Red Bee Propolis Capsules by Confidence USA Drug Interactions
HelloPharmacist Interaction Report
Brazil Red Bee Propolis Capsules by Confidence USA contains propolis, which has documented interactions with a number of medications.
The most serious concern is with drugs broken down by your liver's cytochrome P450 enzyme system—specifically CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1 substrates. At high doses, propolis might theoretically slow how your liver clears these drugs, raising their blood levels.
Lab research supports this possibility, though animal studies at high doses haven't shown the effect in practice; the real-world impact in humans remains unclear.
Read the full breakdown — every affected drug type, severity by severity
Additionally, propolis may interact with blood thinners (anticoagulants) and antiplatelet drugs like warfarin. Lab research shows propolis can interfere with platelet clumping, and animal work suggests it may reduce warfarin's effectiveness by lowering your INR (a blood-clotting measure).
Again, this hasn't been reported in people yet, but it's worth knowing about.
Altogether, these interactions span 911 individual medications. Because propolis affects how your liver handles drugs, the safest move is to check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Brazil Red Bee Propolis Capsules?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Brazil Red Bee Propolis Capsules interact with 921 drugs. Click any drug to see the details.
1 of the 2 ingredients in Brazil Red Bee Propolis Capsules interact with drugs. Each result below shows which ingredient is responsible. Bee Propolis
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Brazil Bee Propolis Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
Read the full Brazil Bee Propolis Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Brazil Bee Propolis Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Brazil Red Bee Propolis Capsules — through 1 ingredient. Tap an ingredient for the detail:
Brazil Bee Propolis ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Brazil Bee Propolis Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Brazil Red Bee Propolis Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bee Propolis
Anticoagulant/Antiplatelet Drugs
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Brazil Red Bee Propolis Capsules, from the product label.
Confidence USA
See all Confidence USA products- Name
- Confidence USA, INC.
- City
- Port Washington
- State
- NY
- ZipCode
- 11050
- Phone Number
- 1-800-887-7161
- Web Address
- ConfidenceUSA.com
Brazil Red Bee Propolis Capsules by Confidence USA: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Brazil Red Bee Propolis Capsules’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Brazil Red Bee Propolis Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Propolis 21 references
- Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
- Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
- Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
- Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
- Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
- Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
- Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
- Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
- Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
- Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
- Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
- Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC