Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Brazil Red Bee Propolis Capsules Ingredients & Drug Interactions

by Confidence USA

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Brazil Red Bee Propolis Capsules is a dietary supplement by Confidence USA with 2 active ingredients. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bee Propolis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Brazil Red Bee Propolis Capsules by Confidence USA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Brazil Red Proprietary Blend” is a proprietary blend — the label gives one combined amount (800 mg) without saying how much of each component you get.

Brazil Red Bee Propolis Capsules contains 2 active ingredients: bee propolis and Brazil bee propolis extract. Propolis is a resinous compound that honey bees make and use to seal their hives.

Both forms in this product are the same active ingredient from the monograph, just listed separately—you're getting propolis as the therapeutic agent. The capsule itself contains inactive ingredients: bovine gelatin (the capsule material), rice flour, microcrystalline cellulose, and magnesium stearate (a binder and flow agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support immunity and cellular health.
  • We looked for evidence on: Common cold, Upper respiratory tract infection (URTI), Coronavirus disease 2019 (COVID-19), Herpes labialis (cold sores), Genital herpes, Oral mucositis — and 4 related terms.
  • The strongest evidence on file: Propolis is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Propolis is rated "Possibly Effective" for Oral mucositis.
  • Also on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI), Gingivitis, Periodontitis, Wound healing, and more.

The evidence on propolis is mixed. For oral mucositis (mouth inflammation from chemotherapy or other causes) and herpes labialis (cold sores), the data we hold rates it as possibly effective—meaning there's some promising research, but it's not yet rock-solid.

For diabetes, propolis is also rated possibly effective on the same basis. For dengue fever, we don't have enough reliable evidence to say one way or the other.

Talk to your pharmacist or doctor about whether this product fits your needs.

The evidence, ingredient by ingredient Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Propolis is generally well tolerated in the short term. The most common side effect is headache—about 7% of people taking 250 mg twice daily for 4 months reported mild headache in one trial.

Allergic reactions are possible, especially if you're sensitive to bee products. Serious allergic reactions are rare but can happen.

If you're allergic to bees or bee products, be cautious. Because there isn't enough reliable safety data, the product should be avoided during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propolis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check the following medication types before adding this product: drugs metabolized by CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2E1 (your pharmacist can tell you if yours fall into these groups), blood thinners and antiplatelet drugs, and warfarin in particular. All carry a Moderate severity rating.

Use the search tool above to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have no allergies to bee products and aren't on medications that depend on liver enzymes to be cleared, this propolis supplement may be worth a try for cold sores, mouth inflammation, or blood sugar support. Steer clear if you're pregnant, breastfeeding, or allergic to bee products.

Before you start, run your medications through the interaction checker on this page—propolis affects how your body processes many drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brazil Red Bee Propolis Capsules, straight from the product label.

Brand Confidence USA
Barcode (UPC) 892483001755
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283347
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brazil Red Bee Propolis Capsules by Confidence USA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
892483001755
IngredientAmount% DV
Bee Propolis0 NP--
Brazil Red Proprietary Blend800 mg--
Brazil Bee Propolis Extract0 NP--

Other ingredients: Bovine Gelatin, Rice Flour, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant, nursing or taking any medications, consult your physician before using this product.

Discontinue use and contact your physician if any adverse reactions occur.

Keep out of reach of children.

If outer safety seal is broken or missing, do not consume.

Formula

Brazil Red - Bee Propolis Capsules is a 100% natural pure Brazilian Bee Propolis extract that contains up to 400% more bee propolis than other bee propolis products on the market.

High quality propolis

Formulation

Research has shown that Brazilian Bee Propolis is the most highly desired and concentrated variety of bee propolis due to the local climate and vegetation. When taken regularly, Brazilian Bee Propolis may support immunity, cellular proliferation, detoxification and anti-aging.

Brazil Red - Bee Propolis Capsules is manufactured by Confidence USA, Inc., an FDA registered manufacturer following strict current Good Manufacturing Practices. (FDA Registration# 10362791850 - Product Code# FP0193)

Made in USA

Supports overall health

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Good Manufacturing Practice GMP

100% Potency guaranteed

General Statements

Other countries: 001-516-767-1860 For more info and reorders: www.ConfidenceUSA.com

Brand IP Statement(s)

Confidence USA Better Products for A Better Life

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adult - Take 2 capsules daily as dietary supplement.

Storage

Store at room temperature, with lid tightly closed.

See for yourself

Brazil Red Bee Propolis Capsules by Confidence USA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Brazil Red Bee Propolis Capsules by Confidence USA

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Brazil Red Proprietary Blend

800 mg per serving

Other (inactive) ingredients: Bovine Gelatin, Rice Flour, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brazil Red Bee Propolis Capsules by Confidence USA Drug Interactions

Want to check YOUR meds against Brazil Red Bee Propolis Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
921Drugs
921 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Brazil Red Bee Propolis Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bee Propolis8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Brazil Red Bee Propolis Capsules, from the product label.

Confidence USA

See all Confidence USA products
Name
Confidence USA, INC.
City
Port Washington
State
NY
ZipCode
11050
Phone Number
1-800-887-7161
Web Address
ConfidenceUSA.com
Pharmacist Counseling Corner

Brazil Red Bee Propolis Capsules by Confidence USA: Common Questions

Does Brazil Red Bee Propolis Capsules by Confidence USA interact with any medications?
Yes. Based on its ingredients, Brazil Red Bee Propolis Capsules has a known interaction with 921 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brazil Red Bee Propolis Capsules contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm allergic to bee stings?
Propolis is made by bees from plant resins, not bee venom, so a bee-sting allergy and propolis sensitivity aren't the same thing. However, if you're allergic to bees or bee products in general—like bee pollen or honey—you're at higher risk for an allergic reaction to propolis. Talk to your pharmacist or doctor first if you have a bee-product allergy.
What's the difference between the two propolis ingredients listed?
Both bee propolis and Brazil bee propolis extract are the same active ingredient—propolis. One may be a whole propolis and the other an extract form, but they work the same way in your body. Together they make up the active part of this capsule.
Will this help with my cold sores?
The evidence says propolis is possibly effective for herpes labialis (cold sores), meaning there's some research supporting it but it's not yet definitive. It may be worth trying, but talk to your pharmacist about what to expect and whether it's right for your situation.
Does this product have fillers?
Yes. The capsule contains rice flour, microcrystalline cellulose, and magnesium stearate as inactive ingredients. These are standard binders and flow agents that help the capsule work properly.
Can I take this while pregnant or breastfeeding?
No. There isn't enough reliable safety information, so propolis is best avoided during pregnancy and while breastfeeding. Talk to your doctor or pharmacist about safer options if you need support during this time.
What are the most common side effects?
Headache is the most common side effect—about 7% of people taking propolis in a trial reported mild headache. Allergic reactions, especially skin reactions in people sensitive to bee products, can occur. Serious allergic reactions are rare.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brazil Red Bee Propolis Capsules label
Go deeper

The Full Monographs Behind Brazil Red Bee Propolis Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Brazil Red Bee Propolis Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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