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Dietary supplement

Buckthorn Bark Extract Ingredients & Drug Interactions

by BulkSupplements.com

Buckthorn Bark Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Buckthorn Bark Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Buckthorn Bark Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for constipation, occasional laxative use, digestive complaints.Based on those ingredients, 99 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Buckthorn bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Buckthorn Bark Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Buckthorn Bark Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Buckthorn Bark Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: buckthorn bark extract, a potent stimulant laxative derived from European buckthorn. That's the whole formula — there are no other active ingredients and no fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: occasional constipation relief.
  • We looked for evidence on: Constipation, bowel regularity, digestive function.
  • The strongest evidence on file: European Buckthorn is rated "Possibly Effective" for Constipation (Natural Medicines).

The evidence we hold supports buckthorn for constipation as possibly effective. That means there's some data backing its traditional use, but more solid research would help confirm how well it really works for most people.

The evidence, ingredient by ingredient European Buckthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use is generally well tolerated, but buckthorn can cause abdominal pain, cramps, or watery diarrhea. The bigger concern is chronic use or overuse: it can deplete potassium (which harms heart and muscle function), cause protein in the urine, and lead to harmless pigment spots in your intestines that usually fade when you stop.

Buckthorn is rated likely unsafe in pregnancy and should be avoided while breastfeeding, since laxatives can pass into breast milk. Because it's a harsh stimulant laxative, use it only under professional guidance — raw berries can be toxic.

Side effects, ingredient by ingredient European Buckthorn

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — European Buckthorn.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 99 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take digoxin (a heart medication) — buckthorn can raise its levels dangerously. Also double-check if you're on warfarin or other blood thinners, diuretics (water pills), or any other stimulant laxatives.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Buckthorn is meant for short-term constipation relief under professional supervision, not daily or long-term use. If you take digoxin, warfarin, diuretics, or other laxatives, talk with your doctor or pharmacist before starting this product.

Pregnant or nursing? Skip it.

Anyone considering it should discuss it with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Buckthorn Bark Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X001B9LL6H
Net contents 100 Gram(s); 3.5 Oz(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 253947
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Buckthorn Bark Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
750 mg
Maximum serving Sizes:
750 mg
Servings per container
133
UPC/BARCODE
X001B9LL6H
IngredientAmount% DV
Buckthorn bark extract750 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

New - Buckthorn Bark Extract Powder by Bulksupplements (100 grams)

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives.

Color may vary

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 750 mg (about 1/3 tsp) up to three times daily, or as directed by a physician.

Storage

Store in a dry, cool place.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Buckthorn Bark Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Buckthorn Bark Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Buckthorn Bark Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size750 mg Dosage formPowder Servings per container133 Amounts shown are per serving.

Buckthorn bark extract

Interacts with
99 drugs
750 mg per serving

European Buckthorn is a shrub whose bark and berries contain compounds that act as a strong, irritant-type laxative. Because it can cause cramping, fl...

Buckthorn bark extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Buckthorn Bark Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Buckthorn Bark Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
99Drugs
1 Major 98 Moderate

Ingredients driving the most interactions

Buckthorn bark extract 99

Individual Drug Interactions

The ingredients in Buckthorn Bark Extract interact with 99 drugs. Click any drug to see the details.

1 of the 1 ingredient in Buckthorn Bark Extract interact with drugs. Each result below shows which ingredient is responsible. Buckthorn bark extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Buckthorn Bark Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Buckthorn bark extract4 drug types · 99 drugs

Digoxin (Lanoxin)

European buckthorn has stimulant laxative effects. Theoretically, the overuse or abuse of European buckthorn might increase the toxicity of cardiac glycoside drugs.

Likelihood Probable Evidence D
Diuretic Drugs

European buckthorn has stimulant laxative effects. Theoretically, overuse of European buckthorn might compound diuretic-induced potassium loss. There is some concern that taking European buckthorn along with potassium-depleting diuretics might increase the risk for hypokalemia.
Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Stimulant Laxatives

European buckthorn has stimulant laxative effects. Concomitant use with stimulant laxative medications might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

European buckthorn has stimulant laxative effects, which can cause diarrhea in some people. Diarrhea can increase the effects of warfarin, which can increase the international normalized ratio (INR) and the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of European buckthorn.

Likelihood Possible Evidence D
Buckthorn bark extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Buckthorn Bark Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Buckthorn Bark Extract by BulkSupplements.com: Common Questions

Does Buckthorn Bark Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Buckthorn Bark Extract has a known interaction with 99 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Buckthorn Bark Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is buckthorn safe to use long-term?
No. Chronic use or overuse can deplete potassium, damage heart and muscle function, cause protein and blood in your urine, and lead to other problems. It's a harsh laxative meant only for short-term use under professional guidance.
Can I take this while pregnant or breastfeeding?
Buckthorn is rated likely unsafe in pregnancy and should be avoided while nursing because laxatives pass into breast milk. Talk with your doctor or pharmacist about safer options.
What side effects should I expect?
Short-term use typically causes abdominal pain, cramps, or watery diarrhea. Long-term use raises the risk of potassium loss (weakness, heart problems), harmless pigment spots in your intestines, and blood or protein in your urine.
How does buckthorn actually work for constipation?
It's a stimulant laxative — it triggers strong contractions in your intestines to move stool. That's why it's harsh and why it shouldn't be used routinely.
Can I combine this with other laxatives?
No. Taking buckthorn with other stimulant laxatives compounds fluid and electrolyte loss, which is dangerous. Use only one at a time, and under professional guidance.
What makes buckthorn different from other laxatives?
Buckthorn is one of the harsher stimulant laxatives available, which is why the facts recommend use only under professional guidance — raw berries can even be toxic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Buckthorn Bark Extract label
Go deeper

The Full Monographs Behind Buckthorn Bark Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

European Buckthorn

Interacts with 99 drugs

European Buckthorn is a shrub whose bark and berries contain compounds that act as a strong, irritant-type laxative. Because it can cause cramping, fluid and electrolyte loss, and the berrie...

Read the full European Buckthorn monograph →
Sources

Sources & How We Checked

Buckthorn Bark Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

European Buckthorn 7 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Tyler VE. Herbs of Choice. Binghamton, NY: Pharmaceutical Products Press, 1994.
  3. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed

See these in context on the European Buckthorn monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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