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Dietary supplement

Buddy Bear Probiotic Natural Orange Flavor Ingredients & Drug Interactions

by Renew Life

Buddy Bear Probiotic Natural Orange Flavor label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Buddy Bear Probiotic Natural Orange Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Buddy Bear Probiotic Natural Orange Flavor is a dietary supplement by Renew Life with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Buddy Bear Probiotic Natural Orange Flavor by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Buddy Bear Probiotic Natural Orange Flavor by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Buddy Bear Probiotic Natural Orange Flavor by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 5 active ingredients: a probiotic blend featuring Lactobacillus acidophilus and Bifidobacterium infantis (live beneficial bacteria), Bifidobacterium (another probiotic organism), and FOS (a type of fiber that feeds good bacteria). The tablet also contains several inactive ingredients, including organic cane extract, orange fruit crystals, natural orange flavor, vegetable stearine, citric acid, and vegetable stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and probiotic support for children.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Rotaviral diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Lactose intolerance, Rotaviral diarrhea, Travelers' diarrhea, and more.

Lactobacillus acidophilus, the main active ingredient we have effectiveness data for, is rated possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated possibly ineffective for atopic disease (allergic conditions), and the evidence for acute respiratory distress syndrome is too limited to rate.

We don't have established effectiveness data in our files for the other ingredients in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like stomach discomfort, abdominal pain, bloating, flatulence, diarrhea, and burping can occur when taking it with other probiotics, but these are uncommon.

In rare cases, L. acidophilus has been linked to serious infections like bacteremia or endocarditis, mostly in people where the bacteria may have translocated from other body sites — this isn't a typical concern for otherwise healthy people. One trial reported a couple of rash cases, though it's unclear whether L. acidophilus itself was responsible.

The safety data shows L. acidophilus is possibly safe in pregnancy, though data are limited; there's no lactation safety rating on file.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication type to double-check is antibiotic drugs — taking them at the same time as this probiotic may reduce the probiotic's effectiveness. Separate the timing by a few hours if you can.

Use the search tool on this page to look up your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a reasonable choice if you're looking for a probiotic to support digestive health or if you've had antibiotic-related diarrhea — though timing matters. If you take antibiotics, talk with your pharmacist about spacing them apart from this product.

Anyone with a compromised immune system or a history of serious infections should check with their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Buddy Bear Probiotic Natural Orange Flavor, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257157133
Net contents 60 Chewable Bear Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71500
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Kosher, Gluten Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Buddy Bear Probiotic Natural Orange Flavor by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
631257157133
IngredientAmount% DV
Total Carbohydrates1.1 Gram(s)1%
Sugar1 Gram(s)--
Calories from Fat2 Calorie(s)--
Total Fat0.2 Gram(s)1%
Total Calories6 Calorie(s)--
FOS100 mg--
Probiotic Blend0 NP--
Bifidus0 NP--
Bifidobacterium0 NP--
Blend0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium infantis0 NP--

Other ingredients: organic Cane extract, Orange fruit crystals, natural Orange flavor, Vegetable Stearine, Citric Acid, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Buddy Bear Probiotic is a natural probiotic supplement formulated for children age 2 and older who are capable of chewing.

Each great-tasting chewable bear tablet contains: ~ Lactobacillus acidophilus ~ Bifidobacterium bifidus ~ Bifidobacterium infantis ~ FOS

Manufactured in a GMP and Kosher facility

Chewable probiotic for kids

1 billion active bifidobacteria and lactobacillus cultures

Contains less than 2% of the recommended daily allowance for Vitamin A, C, Calcium and Iron

This product may contain mild traces of milk proteins from fermentation ingredients.

This product is recommended for those on a low-lactose diet.

Buddy Bear Probiotic contains active Bifidobacteria and Lactobacillus cultures to help support digestive and immune health.*

Formulation

Contains no yeast, wheat, rye, soy, salt or gluten

General Statements

Quality and purity guaranteed

Made in USA

Contains 1 billion active cultures to help support digestive and immune health*

Delicious natural sun-kissed orange flavor

Precautions

Warning: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition.

Keep out of reach of children.

Tamper Evident: Do not use if safety seal is broken or missing.

This product may contain mild traces of milk proteins from fermentation ingredients.

Storage

Best if refrigerated.

General

1008

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Renew Life The digestive care company

Buddy Bear Kids’ Products are formulated by Brenda Watson C.N.C., president of ReNew Life Formulas and the founder of five natural healthcare clinics specializing in digestive care.

Try these other Buddy Bear digestive health products for kids! Buddy Bear Digest A mild, plant-based enzyme blend formulated to assist with digestion and aid nutrient absorption. Many children experience discomfort from incomplete digestion, and these chewable bear tablets can help. Buddy Bear Fiber A blend of natural acacia fiber and larch fiber that supports healthy elimination and helps promote healthy blood sugar levels. Fiber also helps manage your child’s hunger naturally and promote less snacking throughout the day. Buddy Bear DHA An Omega-3 essential fatty acid (EFA) formula that provides the nourishing benefits of natural DHA from deep-sea, cold-water fish. DHA promotes healthy brain and nervous system function, as well as eye health. Buddy Bear Gentle Lax Provides gentle, natural relief from occasional constipation for children over 2 years of age. Each chewable bear tablet blends magnesium with natural herbs to help support regular bowel movements and promote healthy elimination.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults and children over 2 years of age: Chew 1 bear tablet daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Buddy Bear Probiotic Natural Orange Flavor by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Buddy Bear Probiotic Natural Orange Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Buddy Bear Probiotic Natural Orange Flavor by Renew Life

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Total Calories

6 Calorie(s) per serving

FOS

100 mg per serving

Probiotic Blend

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Other (inactive) ingredients: Organic Cane extract, Orange fruit crystals, Natural Orange flavor, Vegetable Stearine, Citric Acid, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Buddy Bear Probiotic Natural Orange Flavor by Renew Life Drug Interactions

Want to check YOUR meds against Buddy Bear Probiotic Natural Orange Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Buddy Bear Probiotic Natural Orange Flavor interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in Buddy Bear Probiotic Natural Orange Flavor interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Buddy Bear Probiotic Natural Orange Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Buddy Bear Probiotic Natural Orange Flavor, from the product label.

Renew Life

Name
Renew Life Formulas
City
Clearwater
State
FL
ZipCode
33765
Phone Number
866-450-1787
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Buddy Bear Probiotic Natural Orange Flavor by Renew Life: Common Questions

Does Buddy Bear Probiotic Natural Orange Flavor by Renew Life interact with any medications?
Yes. Based on its ingredients, Buddy Bear Probiotic Natural Orange Flavor has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Buddy Bear Probiotic Natural Orange Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
You can, but ideally separate them by a few hours — antibiotics can kill off the live organisms in this probiotic, making it less effective. Ask your pharmacist for the best timing for your specific antibiotic.
What does this probiotic actually do?
Lactobacillus acidophilus, the main ingredient, is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. The evidence is strongest for digestive and gut-related issues.
Does it cause side effects?
Most people tolerate it well. Occasional side effects can include bloating, gas, abdominal discomfort, or loose stools — but these are uncommon. Serious infections from L. acidophilus are very rare and almost always happen in people with weakened immune systems.
Is it safe to take while pregnant or breastfeeding?
The data shows L. acidophilus is possibly safe during pregnancy, though information is limited. There's no safety rating on file for breastfeeding. Talk with your doctor or pharmacist for personalized advice about your situation.
What's in this besides the probiotics?
The active ingredients are the Lactobacillus acidophilus and Bifidobacterium organisms, plus FOS (a prebiotic fiber). The rest is inactive ingredients like cane extract, orange flavoring, citric acid, and vegetable-based binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Buddy Bear Probiotic Natural Orange Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Buddy Bear Probiotic Natural Orange Flavor label
Go deeper

The Full Monographs Behind Buddy Bear Probiotic Natural Orange Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Buddy Bear Probiotic Natural Orange Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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