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Dietary supplement

Calanus Oil Ingredients & Drug Interactions

by California Gold Nutrition

Calanus Oil label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calanus Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calanus Oil is a dietary supplement by California Gold Nutrition with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calanus Oil by California Gold Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Calanus Oil by California Gold Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calanus Oil by California Gold Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (90 mg) without saying how much of each component you get.
  • “Calanus Oil” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

Calanus Oil is a 4-ingredient softgel that delivers omega-3 fatty acids and a carotenoid antioxidant. The active ingredients are eicosapentaenoic acid, docosahexaenoic acid (the two main omega-3s found in marine sources), stearidonic acid (another omega-3), and astaxanthin (a pigment from marine algae with antioxidant properties).

The softgel itself is made from gelatin, purified water, glycerin, and sorbitol.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Astaxanthin product and its label doesn't state a use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Our data on astaxanthin's effectiveness shows insufficient reliable evidence to rate it for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome. The evidence hasn't yet reached the standard needed to say whether it works for these uses.

We hold no effectiveness ratings for the omega-3 fatty acids in this product within our monographs.

The evidence, ingredient by ingredient Astaxanthin Calanus Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported orally are abdominal pain, diarrhea, and red-colored stools.

At standard doses (around 6 mg daily), a small number of trial participants experienced increased bowel movements and red stool color; at much higher doses (40 mg daily), severe stomach pain occurred in two patients. During pregnancy, there is not enough safety data, so the safety data advises against use.

The same holds true for breastfeeding—safety data is insufficient, so it's best to avoid it. If you're pregnant or nursing and thinking about this product, talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Astaxanthin Calanus Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Calanus Oil, double-check any drugs metabolized by the liver enzyme CYP3A4 (Moderate severity) and CYP2B6 (Moderate severity)—astaxanthin may slow their breakdown. Because we cannot check the omega-3 and stearidonic acid components, there may be additional interactions not yet documented in our data.

Use the medication checker on this page and talk it over with your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Calanus Oil is an omega-3 and astaxanthin blend that may appeal to you if you're interested in marine-sourced supplements. Because we can't check three of its four active ingredients for drug interactions, and because one ingredient (astaxanthin) theoretically affects how your liver metabolizes certain medications, you should check your exact medications with the tool on this page and review the results with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calanus Oil, straight from the product label.

Brand California Gold Nutrition
Barcode (UPC) 898220019977
Net contents 90 Fish Gelatin Softgel(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 299594
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calanus Oil by California Gold Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
898220019977
IngredientAmount% DV
Eicosapentaenoic Acid15 mg--
Docosahexaenoic Acid20 mg--
Total Fat0.5 Gram(s)1%
Astaxanthin300 mcg--
Calories5 Calorie(s)--
Total Omega-3 Fatty Acids90 mg--
Calanus Oil500 mg--
Stearidonic Acid20 mg--

Other ingredients: Gelatin, Water, Purified, Glycerin, Sorbitol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 softgel daily, with food. Best when taken as directed by a qualified healthcare professional.

Precautions

Warnings: Keep out of reach of children.

Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.

Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.

Sealed for your protection. Do not use seal is missing or broken.

Contains: Fish (Tilapia) and crustacean shellfish (Calanus oil).

This product is not manufactured with milk, eggs, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in a third-party, audited and registered cGMP compliant facility that may process other products that contain these allergens or ingredients.

Storage

Best stored at controlled room temperature 20 degrees C to 25 degrees C (68 degrees F to 77 degrees F). Improper storage conditions, such as extended exposure to sunlight, high heat & humidity can cause product degradation over time.

Brand IP Statement(s)

California Gold Nutrition is a registered trademark of Madre Labs, LLC

Formula

Arctic omega-3s from calanus finmarchicus EPA DHA SDA Astaxanthin

Formulation

Formulated to contain No gluten No GMOs No soy

This product is not manufactured with milk, eggs, tree nuts, peanuts, wheat, soy, sesame, or gluten.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calanus Oil by California Gold Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calanus Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calanus Oil by California Gold Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Astaxanthin

Interacts with
671 drugs
300 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Calanus Oil

No known
interactions
500 mg per serving Form: Marine Zooplankton

Calanus oil is a marine omega-3 oil made from a small Arctic zooplankton (Calanus finmarchicus). It is rich in omega-3 fatty acids bound in a unique '...

Calanus Oil monograph & interactions
  • › Total Omega-3 Fatty Acids

Other (inactive) ingredients: Gelatin, Water, Purified, Glycerin, Sorbitol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calanus Oil by California Gold Nutrition Drug Interactions

Want to check YOUR meds against Calanus Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

Astaxanthin 671

Individual Drug Interactions

The ingredients in Calanus Oil interact with 671 drugs. Click any drug to see the details.

1 of the 2 ingredients in Calanus Oil interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Calanus Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calanus Oil, from the product label.

California Gold Nutrition

See all California Gold Nutrition products
Name
Madre Labs, LLC
Street Address
301 North Lake Avenue, Suite 500
City
Pasadena
State
CA
ZipCode
91101
Web Address
www.calgn.com
Pharmacist Counseling Corner

Calanus Oil by California Gold Nutrition: Common Questions

Does Calanus Oil by California Gold Nutrition interact with any medications?
Yes. Based on its ingredients, Calanus Oil has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calanus Oil contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is astaxanthin, and what's it doing in this product?
Astaxanthin is a red-orange pigment and antioxidant found naturally in marine plants and animals. It's in Calanus Oil to add antioxidant support alongside the omega-3 fatty acids. Our data doesn't yet show enough reliable evidence that it works for specific health claims, though research is ongoing.
Can I take Calanus Oil if I'm pregnant or breastfeeding?
No, not without talking to your doctor first. There isn't enough safety data during pregnancy or while breastfeeding, so the safety data advises against it. Your own healthcare provider can weigh the pros and cons for your specific situation.
What side effects should I watch for?
Astaxanthin is generally well tolerated, but some people report abdominal pain, diarrhea, or red-colored stools. At typical doses these are uncommon; at very high doses (much higher than this product), severe stomach pain has been reported in a small number of cases. Stop and call your doctor if you have severe abdominal pain.
Why can't you check three of the ingredients for drug interactions?
We don't hold interaction data for eicosapentaenoic acid, docosahexaenoic acid, or stearidonic acid in our current monographs. That doesn't mean they don't interact with anything—it means we haven't compiled that information yet. That's why checking your specific medications before you start is so important.
Is there any evidence this product works for age-related macular degeneration or cognitive decline?
Our data shows insufficient reliable evidence to say whether astaxanthin works for age-related macular degeneration, cognitive decline, Alzheimer disease, or any of the other uses we reviewed. Research is still ongoing, but we can't yet confirm benefit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calanus Oil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calanus Oil label
Go deeper

The Full Monographs Behind Calanus Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Calanus Oil

Calanus oil is a marine omega-3 oil made from a small Arctic zooplankton (Calanus finmarchicus). It is rich in omega-3 fatty acids bound in a unique 'wax ester' form, and early research sugg...

Read the full Calanus Oil monograph →
Sources

Sources & How We Checked

Calanus Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Calanus Oil 3 references
  1. Cook CM, Larsen TS, Derrig LD, Kelly KM, Tande KS. Wax ester rich oil from the marine crustacean, Calanus finmarchicus, is a bioavailable source of EPA and DHA for human consumption. Lipids. 2016;51(10):1137-1144.
  2. Tande KS, Vo TD, Lynch BS. Clinical safety evaluation of marine oil derived from Calanus finmarchicus. Regul Toxicol Pharmacol. 2016;80:25-31. PubMed
  3. Dadová K, Petr M, Steffl M, et al. Effect of calanus oil supplementation and 16 week exercise program on selected fitness parameters in older women. Nutrients. 2020 Feb 14;12(2):481. PubMed

See these in context on the Calanus Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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