Calcium-D-Glucarate Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Calcium-D-Glucarate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Calcium-D-Glucarate is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for detoxification support, hormone balance, estrogen metabolism.Based on those ingredients, 126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Calcium-D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Calcium-D-Glucarate by Pure Encapsulations
Ask about any prescription or over-the-counter medication and we check it for interactions with Calcium-D-Glucarate by Pure Encapsulations — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Calcium-D-Glucarate by Pure Encapsulations
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: calcium D-glucarate, a compound derived from glucaric acid that occurs naturally in some fruits and vegetables. The capsule itself is vegetarian.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that calcium D-glucarate works for breast cancer, prostate cancer, or colorectal cancer — the ratings are all insufficient reliable evidence to rate. If you're considering it for any of these conditions, that's a conversation to have with your doctor about what the current science actually supports.
How safe is it?
Some data gaps
Calcium D-glucarate appears generally well tolerated in the small studies available, but long-term safety data in humans hasn't been established, so we don't have a complete picture of what happens with extended use. The product should be avoided during pregnancy — there isn't enough safety information to recommend it.
It should also be avoided while breastfeeding, since safety data during lactation is unknown.
Meds to double-check
Moderate interaction found
Check your medications against this product if you take glucuronidated drugs (a large category that includes many common medications — the checker will identify yours), drink alcohol regularly, or take kanamycin. Moderate interactions exist with the first two; a Minor interaction with the antibiotic.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
Calcium D-glucarate is a single-ingredient supplement that may affect how your body clears a wide range of medications. Before you take it, run your exact prescriptions through the interaction checker on this page — especially if you take any medications regularly.
Talk with your doctor or pharmacist about whether it's right for you and whether the timing of doses matters.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Calcium-D-Glucarate, straight from the product label.
| Brand | Pure Encapsulations |
|---|---|
| Barcode (UPC) | 766298003566 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 7, 2019 |
| DSLD ID | 183962 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Calcium-D-Glucarate by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calcium-D-Glucarate | 1000 mg | -- |
Other ingredients: Vegetarian Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Store in a cool, dry place.
Suggested/Recommended/Usage/Directions
Recommendations: As a dietary supplement, take 2 capsules, 1-3 times daily, with meals.
Precautions
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
General Statements
Scan to learn about our hypoallergenic supplements
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.
Supports detoxification and healthy cells
Formulation
Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org
Gluten-free, Non-GMO & Hypoallergenic
Gluten-free, Non-GMO & Hypoallergenic
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
GF
Formula
CDG Glucarate This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, Inc. and protected by U.S. Patent 7,662,863.
Brand IP Statement(s)
CDG Glucarate This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, Inc. and protected by U.S. Patent 7,662,863.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
v5 code: CG1
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Calcium-D-Glucarate by Pure Encapsulations label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Calcium-D-Glucarate by Pure Encapsulations
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Calcium-D-Glucarate
Interacts with126 drugs
Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...
Calcium-D-Glucarate monograph & interactionsOther (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.
Calcium-D-Glucarate by Pure Encapsulations Drug Interactions
HelloPharmacist Interaction Report
Calcium-D-Glucarate by Pure Encapsulations interacts with a notable number of medications, primarily those that rely on a liver process called glucuronidation to be cleared from your body.
The most serious concern is with glucuronidated drugs — a broad category that includes many common medications. Calcium D-glucarate can speed up how quickly your body eliminates these drugs, which may make them less effective.
We're talking about a Moderate severity interaction across a large group of medications.
Read the full breakdown — every affected drug type, severity by severity
The supplement also has a Moderate interaction with alcohol. If you drink, alcohol may reduce how well calcium D-glucarate works in your body.
Additionally, there's a Minor interaction with kanamycin (an antibiotic), where calcium D-glucarate may increase how fast your body clears it and lower its blood levels.
Altogether, these interactions span 126 individual medications. Because glucuronidated drugs are so common — and because you may not know offhand which of your medications fall into that category — it's important to run each of your prescriptions through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Calcium-D-Glucarate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Calcium-D-Glucarate interact with 126 drugs. Click any drug to see the details.
1 of the 1 ingredient in Calcium-D-Glucarate interact with drugs. Each result below shows which ingredient is responsible. Calcium-D-Glucarate
KanamycinKantrex
How Kanamycin interacts with Calcium-D-Glucarate — through 1 ingredient. Tap an ingredient for the detail:
Calcium-d-glucarateKanamycin Minor
Interaction Summary
Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Read the full Calcium-d-glucarate + Kanamycin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Calcium-D-Glucarate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Calcium-D-Glucarate
Alcohol (Ethanol)
Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.
Glucuronidated Drugs
Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.
Kanamycin
Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.
Brand information
Manufacturer and brand details for Calcium-D-Glucarate, from the product label.
Pure Encapsulations
See all Pure Encapsulations products- Name
- Pure Encapsulations
- Street Address
- 490 Boston Post Road
- City
- Sudbury
- State
- MA
- Phone Number
- 1-800-753-2277
- Web Address
- www.PureEncapsulations.com
Calcium-D-Glucarate by Pure Encapsulations: Common Questions
Does Calcium-D-Glucarate by Pure Encapsulations interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
Will this work for cancer prevention?
What is calcium D-glucarate, and where does it come from?
Is it safe to take long-term?
Does alcohol affect how well this supplement works?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Calcium-D-Glucarate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Calcium-D-Glucarate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Calcium-D-Glucarate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Calcium D-glucarate 5 references
- Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
- Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
- Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
- Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
- Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC