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Dietary supplement

Calcium-D-Glucarate Ingredients & Drug Interactions

by Pure Encapsulations

Calcium-D-Glucarate label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calcium-D-Glucarate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calcium-D-Glucarate is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for detoxification support, hormone balance, estrogen metabolism.Based on those ingredients, 126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Calcium-D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calcium-D-Glucarate by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Calcium-D-Glucarate by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calcium-D-Glucarate by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: calcium D-glucarate, a compound derived from glucaric acid that occurs naturally in some fruits and vegetables. The capsule itself is vegetarian.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calcium D-glucarate product and its label doesn't state a use — see Calcium D-glucarate's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that calcium D-glucarate works for breast cancer, prostate cancer, or colorectal cancer — the ratings are all insufficient reliable evidence to rate. If you're considering it for any of these conditions, that's a conversation to have with your doctor about what the current science actually supports.

The evidence, ingredient by ingredient Calcium D-glucarate

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium D-glucarate appears generally well tolerated in the small studies available, but long-term safety data in humans hasn't been established, so we don't have a complete picture of what happens with extended use. The product should be avoided during pregnancy — there isn't enough safety information to recommend it.

It should also be avoided while breastfeeding, since safety data during lactation is unknown.

Side effects, ingredient by ingredient Calcium D-glucarate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calcium D-glucarate.
  • The most serious interaction on file is rated Moderate.
  • For scale: 126 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take glucuronidated drugs (a large category that includes many common medications — the checker will identify yours), drink alcohol regularly, or take kanamycin. Moderate interactions exist with the first two; a Minor interaction with the antibiotic.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Calcium D-glucarate is a single-ingredient supplement that may affect how your body clears a wide range of medications. Before you take it, run your exact prescriptions through the interaction checker on this page — especially if you take any medications regularly.

Talk with your doctor or pharmacist about whether it's right for you and whether the timing of doses matters.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calcium-D-Glucarate, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298003566
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 183962
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calcium-D-Glucarate by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
766298003566
IngredientAmount% DV
Calcium-D-Glucarate1000 mg--

Other ingredients: Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 2 capsules, 1-3 times daily, with meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Supports detoxification and healthy cells

Formulation

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GF

Formula

CDG Glucarate This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, Inc. and protected by U.S. Patent 7,662,863.

Brand IP Statement(s)

CDG Glucarate This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, Inc. and protected by U.S. Patent 7,662,863.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

v5 code: CG1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calcium-D-Glucarate by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calcium-D-Glucarate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calcium-D-Glucarate by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Calcium-D-Glucarate

Interacts with
126 drugs
1000 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium-D-Glucarate monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calcium-D-Glucarate by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Calcium-D-Glucarate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
126Drugs
125 Moderate 1 Minor

Ingredients driving the most interactions

Calcium-D-Glucarate 126

Individual Drug Interactions

The ingredients in Calcium-D-Glucarate interact with 126 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calcium-D-Glucarate interact with drugs. Each result below shows which ingredient is responsible. Calcium-D-Glucarate

Each ingredient & the kinds of drugs it affects

For each ingredient in Calcium-D-Glucarate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium-D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium-D-Glucarate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calcium-D-Glucarate, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Calcium-D-Glucarate by Pure Encapsulations: Common Questions

Does Calcium-D-Glucarate by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Calcium-D-Glucarate has a known interaction with 126 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calcium-D-Glucarate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against it in both cases. There isn't enough information to know it's safe during pregnancy, and safety while breastfeeding is unknown. Talk with your doctor if you're pregnant or nursing and considering this supplement.
Will this work for cancer prevention?
We don't have reliable evidence that it works for breast, prostate, or colorectal cancer. The research so far isn't conclusive enough to rate its effectiveness for those uses.
What is calcium D-glucarate, and where does it come from?
It's a compound derived from glucaric acid, which occurs naturally in some fruits and vegetables. Your body also produces small amounts of it.
Is it safe to take long-term?
Small studies show it's generally well tolerated, but we don't have solid long-term safety data in humans yet. If you're thinking about taking it for a long time, check in with your doctor first.
Does alcohol affect how well this supplement works?
Yes — there's a Moderate interaction. Alcohol may reduce calcium D-glucarate's activity, so if you drink regularly, that's worth discussing with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calcium-D-Glucarate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calcium-D-Glucarate label
Go deeper

The Full Monographs Behind Calcium-D-Glucarate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph →
Sources

Sources & How We Checked

Calcium-D-Glucarate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium D-glucarate 5 references
  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.

See these in context on the Calcium D-glucarate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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