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Dietary supplement

California Poppy Ingredients & Drug Interactions

by Five Flavors Herbs

California Poppy label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking California Poppy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

California Poppy is a dietary supplement by Five Flavors Herbs with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping (insomnia), mild aches and pains.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fresh California Poppy whole plant extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against California Poppy by Five Flavors Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with California Poppy by Five Flavors Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of California Poppy by Five Flavors Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fresh California poppy whole plant extract. California poppy is a plant used traditionally for relaxation and sleep support, though the scientific evidence for its effectiveness remains limited.

The liquid also contains cane alcohol as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see California Poppy's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Calms and soothes mild discomfort.
  • We looked for evidence on: Anxiety, Insomnia, Restlessness, Nervous tension.
  • The closest evidence on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Insomnia.

The evidence for California poppy isn't established yet in our data. Studies haven't provided reliable evidence to say whether it works for anxiety, insomnia, or bedwetting.

That doesn't mean it doesn't work—just that we don't have solid proof either way. More research is needed.

The evidence, ingredient by ingredient California Poppy

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

California poppy is generally well tolerated for short-term use, though human safety data are limited. In studies where it was combined with hawthorn and magnesium, some people reported muscular stiffness, morning fatigue, and nausea, though it's unclear whether these effects came from California poppy alone, the other ingredients, or the combination.

For pregnancy and breastfeeding, the safety data aren't sufficient to say it's okay. The facts advise against use during pregnancy and while breastfeeding.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient California Poppy

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — California Poppy.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check any medications that slow down your central nervous system: sleep aids, anti-anxiety drugs, opioids, sedatives, and certain antihistamines. California poppy may increase their sedative effects.

Use the medication checker on this page to look up your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

California poppy may appeal to you if you're looking for a traditional herb for sleep or anxiety support, but the scientific evidence for it is still limited. If you take any sedating medications—sleep aids, anti-anxiety drugs, pain relievers, or even certain allergy medicines—check with us first.

Avoid it during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about California Poppy, straight from the product label.

Brand Five Flavors Herbs
Barcode (UPC) 635983568898
Net contents 2 Fluid Ounce(s); 59 mL
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 320691
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for California Poppy by Five Flavors Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Milliliter(s)
Maximum serving Sizes:
1 Milliliter(s)
Servings per container
59
UPC/BARCODE
635983568898
IngredientAmount% DV
Fresh California Poppy whole plant extract1 mL--

Other ingredients: Cane Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use 1 ml, 2-3 times daily in water, or as directed. Shake well before using.

Precautions

Caution Consult with your physician or a qualified herbalist before using if pregnant or nursing.

Keep out of reach of children.

Formulation

Integrating Traditions for Wellness Five Flavors Herbs creates and delivers effective, sustainable herbal remedies by integrating East Asian medicine principles with Western herbs and modern research. Calms & Soothes mild discomfort

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

California Poppy by Five Flavors Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

California Poppy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in California Poppy by Five Flavors Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Milliliter(s) Dosage formLiquid Servings per container59 Amounts shown are per serving.

Fresh California Poppy whole plant extract

Interacts with
248 drugs
1 mL per serving

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is...

Fresh California Poppy whole plant extract monograph & interactions

Other (inactive) ingredients: Cane Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

California Poppy by Five Flavors Herbs Drug Interactions

Want to check YOUR meds against California Poppy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Fresh California Poppy whole plant extract 248

Individual Drug Interactions

The ingredients in California Poppy interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in California Poppy interact with drugs. Each result below shows which ingredient is responsible. Fresh California Poppy whole plant extract

Each ingredient & the kinds of drugs it affects

For each ingredient in California Poppy with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Fresh California Poppy whole plant extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Laboratory research shows that California poppy has sedative effects.

Likelihood Possible Evidence D
Fresh California Poppy whole plant extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for California Poppy, from the product label.

Five Flavors Herbs

See all Five Flavors Herbs products
Name
Five Flavors Herbs, Inc.
Street Address
344 40th St.
City
Oakland
State
CA
ZipCode
94609
Web Address
www,fiveflavorsherbs.com
Pharmacist Counseling Corner

California Poppy by Five Flavors Herbs: Common Questions

Does California Poppy by Five Flavors Herbs interact with any medications?
Yes. Based on its ingredients, California Poppy has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
California Poppy contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take California poppy if I'm pregnant or breastfeeding?
The safety data aren't strong enough to say yes. The facts advise against it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about whether it's right for your situation.
Does California poppy actually work for sleep or anxiety?
The research so far hasn't provided reliable evidence that it does. That doesn't mean people don't find it helpful—just that we don't have solid proof yet.
What side effects might I notice?
Data on side effects are limited. In one study where it was combined with other herbs, some people reported muscular stiffness, morning fatigue, and nausea—though it's unclear if California poppy alone caused them.
Why can't I take this with sleep medications?
Laboratory research shows California poppy has sedative effects. Taking it with drugs that already slow down your brain could increase drowsiness and sedation beyond what either alone would cause.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if California Poppy is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

California Poppy label
Go deeper

The Full Monographs Behind California Poppy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

California Poppy

Interacts with 248 drugs

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are...

Read the full California Poppy monograph →
Sources

Sources & How We Checked

California Poppy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

California Poppy 3 references
  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

See these in context on the California Poppy monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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