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Dietary supplement

Calm Drops Lozenges Raspberry Flavored Ingredients & Drug Interactions

by Nature's Way

Calm Drops Lozenges Raspberry Flavored label
See full label image
Lozenge Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calm Drops Lozenges Raspberry Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calm Drops Lozenges Raspberry Flavored is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma-Aminobutyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calm Drops Lozenges Raspberry Flavored by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Calm Drops Lozenges Raspberry Flavored by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calm Drops Lozenges Raspberry Flavored by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This lozenge contains one active ingredient: GABA (gamma-aminobutyric acid), a natural brain chemical your body makes to help promote relaxation. The rest is inactive ingredients that give it flavor and texture — cane sugar, brown rice syrup, natural flavors, citric acid, and vegetable and fruit juice.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote relaxed mental state and ease stress.
  • We looked for evidence on: Anxiety, Psychological well-being, stress reduction, relaxation.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Psychological well-being.

The evidence for GABA lozenges isn't established yet. Our data shows insufficient reliable evidence to rate it for anxiety, ADHD, athletic performance, chronic bronchitis, and cerebral palsy — the conditions it's typically marketed for.

That doesn't mean it doesn't work; it means the studies we have aren't robust enough to say one way or the other.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

GABA is generally well tolerated when taken by mouth or as a lozenge, though a full safety evaluation hasn't been done. Short-term use appears okay, but we don't have good long-term safety data.

The most common side effects reported orally are drowsiness, nausea, gastric upset, minor throat burning, and muscle weakness. Because safety information is limited, your doctor should weigh whether it's right for you.

There isn't enough data on file to know whether it's safe in pregnancy or while breastfeeding — talk with your doctor or pharmacist before using it if you're pregnant or nursing.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medication (antihypertensives), double-check before starting — GABA might lower your pressure further. Also flag any CNS depressants you're on, like sleep aids or certain pain or anxiety medications, since the combination could increase drowsiness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people looking for a natural relaxation aid, but the evidence that it actually works isn't solid yet. If you take blood pressure medication or anything that makes you drowsy, check with your pharmacist first.

And if you're pregnant, nursing, or taking any prescription drugs, talk to your doctor before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calm Drops Lozenges Raspberry Flavored, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674149706
Net contents 24 Lozenge(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 333709
Product type Non-nutrient/non-botanical
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calm Drops Lozenges Raspberry Flavored by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
24
UPC/BARCODE
033674149706
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Gamma-Aminobutyric Acid100 mg--

Other ingredients: Cane Sugar, Brown Rice syrup, Natural Flavors, Citric Acid, Vegetable and Fruit Juice

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Soothe stress within 60 minutes Works quickly to help ease stress

Gluten free. No salt, wheat, soy, egg, peanut, dairy, or gelatin.

Packaged and tested in the USA

Vegan Gelatin Free

Vegan Gelatin Free

Fast-acting support to help calm the mind in response to stress

Drug-free, non-habit forming lozenges

Formula

Calm Drops Lozenges with Fast-Acting GABA Fast-acting GABA works within 60 minutes to promote a relaxed mental state

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 lozenge daily as needed. Allow lozenge to dissolve slowly in mouth: do not chew.

Precautions

Not formulated for children. Keep out of reach of children.

Do not exceed recommended dose. Do not use if package is open or torn, or if individual pieces are unwrapped.

Warning: Do not take if you are pregnant or nursing. If you have high blood pressure or if you are taking any medications, consult a healthcare professional before use.

Storage

Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Copyright 2024 Nature's Way Brands, LLC

General Statements

Questions? 1-800-962-8873/ naturesway.com

Individually wrapped lozenges are designed for on-the-go use Explore more products at NATURESWAY.COM

Seals/Symbols

Vegan Gelatin Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calm Drops Lozenges Raspberry Flavored by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calm Drops Lozenges Raspberry Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calm Drops Lozenges Raspberry Flavored by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container24 Amounts shown are per serving.

Gamma-Aminobutyric Acid

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma-Aminobutyric Acid monograph & interactions

Other (inactive) ingredients: Cane Sugar, Brown Rice syrup, Natural Flavors, Citric Acid, Vegetable and Fruit Juice. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calm Drops Lozenges Raspberry Flavored by Nature's Way Drug Interactions

Want to check YOUR meds against Calm Drops Lozenges Raspberry Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma-Aminobutyric Acid 419

Individual Drug Interactions

The ingredients in Calm Drops Lozenges Raspberry Flavored interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calm Drops Lozenges Raspberry Flavored interact with drugs. Each result below shows which ingredient is responsible. Gamma-Aminobutyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Calm Drops Lozenges Raspberry Flavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma-Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma-Aminobutyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calm Drops Lozenges Raspberry Flavored, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Calm Drops Lozenges Raspberry Flavored by Nature's Way: Common Questions

Does Calm Drops Lozenges Raspberry Flavored by Nature's Way interact with any medications?
Yes. Based on its ingredients, Calm Drops Lozenges Raspberry Flavored has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calm Drops Lozenges Raspberry Flavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Drowsiness is one of the most commonly reported side effects when GABA is taken by mouth, so it's possible. If you try it, take note of how you feel, especially if you need to drive or operate machinery.
Is this lozenge safe to take while I'm breastfeeding?
There isn't enough safety information to know. The data advises against use while breastfeeding unless your doctor says it's okay — talk with your doctor or pharmacist about your situation.
Does GABA actually work for anxiety?
We have insufficient reliable evidence to say whether it works for anxiety. The research so far isn't strong enough to confirm it, so you might want to talk with your doctor about other options with better evidence behind them.
Are there any other side effects I should know about?
The most common ones are drowsiness, nausea, gastric upset, minor throat burning, and muscle weakness. One rare case of temporary stopped menstruation was reported with oral GABA. If anything unusual happens, stop and tell your doctor.
What other ingredients are in these lozenges?
The inactive ingredients are cane sugar, brown rice syrup, natural flavors, citric acid, and vegetable and fruit juice — basically flavoring and sweetener to make the lozenge taste good and dissolve in your mouth.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calm Drops Lozenges Raspberry Flavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calm Drops Lozenges Raspberry Flavored label
Go deeper

The Full Monographs Behind Calm Drops Lozenges Raspberry Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

Calm Drops Lozenges Raspberry Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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