Can-Sol Ingredients & Drug Interactions
by Pure Herbs
What is this page for?
First and foremost: checking Can-Sol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Can-Sol is a dietary supplement by Pure Herbs with 3 active ingredients. Its ingredients are commonly taken for psoriasis (topical), eczema and other skin conditions, digestive upset.Based on those ingredients, 1,362 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oregon Grape Root Extract, Chaparral Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Can-Sol by Pure Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Can-Sol by Pure Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Can-Sol by Pure Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Can-Sol is a liquid formula with 3 active ingredients: Oregon grape root extract, chaparral leaf extract, and fragrant waterlily root extract. The extract forms mean the active compounds are concentrated from the plant material.
The product also contains water and grain spirits as inactive ingredients (the liquid base).
Does it work?
Couldn't assess
Oregon grape is possibly effective for psoriasis. For other conditions — atopic dermatitis (eczema), acid reflux (GERD), and peptic ulcers — the evidence we hold isn't strong enough to rate its effectiveness.
Chaparral and fragrant waterlily root have no effectiveness ratings in our data, so we can't speak to what they're meant to do in this formula.
How safe is it?
Well-documented data
Oregon grape is generally well tolerated when applied to skin, but oral use (which this product is) hasn't been studied as thoroughly and should be approached carefully. Chaparral carries serious safety concerns — it's been linked to liver and kidney damage, including jaundice, cirrhosis, and in rare cases liver failure requiring transplant.
Berberine-containing plants like Oregon grape are traditionally avoided in pregnancy, and the product should not be used then. Both Oregon grape and chaparral should be avoided while breastfeeding — berberine may pass to infants, and chaparral poses toxicity risks.
Fragrant waterlily root has limited safety data; there's not enough information to know if it's safe in pregnancy or while breastfeeding.
Meds to double-check
Moderate interaction found
Check with your pharmacist if you take blood thinners (anticoagulants or antiplatelets like warfarin or clopidogrel), blood pressure medications (especially amlodipine), sedating drugs, diabetes medications, or cyclosporine. Additionally, avoid this product if you take any medication toxic to the liver, since chaparral may compound that damage.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take any blood thinners, blood pressure medications, diabetes drugs, sedatives, or drugs metabolized by your liver, you need to check this product with your pharmacist before starting. Chaparral's toxicity profile is a serious concern and should factor into your decision.
Talk to your pharmacist about whether Can-Sol is right for you and your medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Can-Sol, straight from the product label.
| Brand | Pure Herbs |
|---|---|
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 327469 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Can-Sol by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1888 mg | -- |
| Oregon Grape Root Extract | 0 NP | -- |
| Chaparral Leaf Extract | 0 NP | -- |
| Fragrant Waterlily Root Extract | 0 NP | -- |
Other ingredients: Water, Distilled, Grain Spirits
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.
Shake well before use
Formulation
Beneficial for maintaining a healthy intestinal flora.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: Rare reports of serious liver disease have been associated with ingestion of chaparral.
Ask a healthcare professional before use if you have or have had liver problems, frequently use alcoholic beverages, or are taking any medication.
Stop use and see a doctor if you develop symptoms that may signal liver problems.
Not intended for use by pregnant or nursing women.
Keep out of reach of children
Brand IP Statement(s)
Pure Herbs, Ltd. Natural Herbal Extracts
FDA Statement of Identity
Dietary Supplement
General Statements
"No expense has been spared to provide the finest nature has to offer."
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Can-Sol by Pure Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Can-Sol by Pure Herbs
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Water, Distilled, Grain Spirits. These complete the product’s ingredient list but are not active constituents.
Can-Sol by Pure Herbs Drug Interactions
HelloPharmacist Interaction Report
Can-Sol by Pure Herbs contains Oregon grape root extract and chaparral leaf extract, both of which interact with medications.
Oregon grape is the primary concern here — it contains berberine, which can inhibit several liver enzymes (CYP2D6, CYP2C9, and CYP3A4) that break down many drugs. This means Oregon grape can raise blood levels of medications metabolized by those pathways, potentially making them stronger or causing side effects.
The most serious documented interaction is with blood thinners (anticoagulant or antiplatelet drugs) — berberine may increase bleeding risk by interfering with how platelets clump together.
Read the full breakdown — every affected drug type, severity by severity
Oregon grape also interacts with blood pressure medications (antihypertensive drugs), sedating medications (CNS depressants), blood sugar medications (antidiabetes drugs), and cyclosporine (an immunosuppressant). Each of these interactions carries Moderate severity.
Additionally, chaparral leaf extract can have additive liver damage when combined with other drugs that are toxic to the liver.
Fragrant waterlily root extract, the third ingredient, has no documented interactions in our data. Altogether, these interactions span 1,341 individual medications.
Before you start Can-Sol, run your exact medications through the interaction checker below — especially if you take any blood thinners, blood pressure drugs, diabetes medications, sedatives, or medications metabolized by your liver.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Can-Sol?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Can-Sol interact with 1,362 drugs. Click any drug to see the details.
2 of the 3 ingredients in Can-Sol interact with drugs. Each result below shows which ingredient is responsible. Oregon Grape Root Extract Chaparral Leaf Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregon Grape Root Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Abiraterone interactionOregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Abiraterone Acetate interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregon Grape Root Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.
Read the full Oregon Grape Root Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acarbose interactionOregon Grape Root ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Oregon Grape Root Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Oregon Grape Root Extract + Acebutolol interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregon Grape Root Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Oregon Grape Root ExtractCns Depressants Moderate
Interaction Summary
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape Root Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Aspirin interactionOregon Grape Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregon Grape Root Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregon Grape Root Extract + Acetaminophen, Aspirin, Caffeine interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Can-Sol — through 1 ingredient. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Butalbital, Caffeine interactionOregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape Root Extract + Acetaminophen, Butalbital, Codeine interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionOregon Grape Root ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.
Read the full Oregon Grape Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Caffeine, Codeine interactionOregon Grape Root ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape Root Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Caffeine, Isometheptene interactionOregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Oregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionChaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Can-Sol — through 2 ingredients. Tap an ingredient for the detail:
Chaparral Leaf ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral Leaf Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionOregon Grape Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
Read the full Oregon Grape Root Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Can-Sol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Oregon Grape Root Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro and in vivo research suggests that berberine, a constituent of Oregon grape, can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, Oregon grape might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research suggests that berberine, a constituent of Oregon grape, can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that berberine, a constituent of Oregon grape, can have hypotensive effects. Also, an analysis of clinical evidence suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Cns Depressants
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Animal research suggests that berberine, a constituent of Oregon grape, can have sedative effects.
Cyclosporine (Neoral, Sandimmune)
Theoretically, Oregon grape might increase the effects and adverse effects of cyclosporine.
Berberine, a constituent of Oregon grape, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2C9 (CYP2C9).
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2D6 (CYP2D6).
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, moderately inhibits cytochrome P450 3A4 (CYP3A4).
P-Glycoprotein Substrates
Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.
In vitro research suggests that Oregon grape extracts inhibit P-gp efflux.
Chaparral Leaf Extract
Hepatotoxic Drugs
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Brand information
Manufacturer and brand details for Can-Sol, from the product label.
Pure Herbs
See all Pure Herbs products- Name
- Pure Herbs, Ltd.
- City
- Sterling Heights
- State
- MI
- Phone Number
- (800) 860-4372
- Web Address
- www.pureherbs.com
Can-Sol by Pure Herbs: Common Questions
Does Can-Sol by Pure Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I use Can-Sol if I'm pregnant or breastfeeding?
What is Oregon grape used for in this product?
Is chaparral safe to use?
Can Oregon grape cause side effects?
Why does this product have so many drug interactions?
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The Full Monographs Behind Can-Sol’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Oregon Grape
Interacts with 1,218 drugsOregon grape is a shrub whose root contains berberine and related compounds. The strongest (though still modest) evidence is for topical creams that may slightly ease psoriasis; evidence for...
Read the full Oregon Grape monograph → Herb & supplement monographChaparral
Interacts with 370 drugsChaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious and sometimes irreversible liver and kidn...
Read the full Chaparral monograph → Herb & supplement monographWhite Lily
White Lily (Lilium candidum) is a flowering plant used mostly in traditional skin care, where its bulb- or flower-infused oils are applied for minor skin problems and soothing. Good-quality...
Read the full White Lily monograph →Sources & How We Checked
Can-Sol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 39 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oregon Grape 21 references
- Wiesenauer M, Lydtke R. Mahonia aquifolium in patients with Psoriasis vulgaris; an intraindividual study. Phytomedicine 1996;3:231-5.
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Gulliver WP, Donsky HJ. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Am J Ther 2005;12:398-406. PubMed
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Fan Y, Zhou Z, Zhang L. Effect of Oregon grape root extracts on P-glycoprotein mediated transport in in vitro cell lines. J Pharm Pharm Sci 2024;26:11927. PubMed
Chaparral 16 references
- Smith BC, Desmond PV. Acute hepatitis induced by ingestion of the herbal medication chaparral. Aust N Z J Med 1993;23:526.. PubMed
- Gordon DW, Rosenthal G, Hart J, et al. Chaparral ingestion: the broadening spectrum of liver injury caused by herbal medications. JAMA 1995;273:489-90.
- Batchelor WB, Heathcote J, Wanless IR. Chaparral-induced hepatic injury. Am J Gastroenterol 1995;90:831-3.
- Katz M, Saibil F. Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6.
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med 1997;157:913-9. DOI
- Heron S, Yarnell E. The safety of low-dose Larrea tridentata (DC) Coville (creosote bush or chaparral): a retrospective clinical study. J Altern Complement Med 2001;7:175-85..
- Chaparral-induced toxic hepatitis-California and Texas, 1992. MMWR Morb Mortal Wkly Rep 1992;41:812-4.. DOI
- Estes JD, Stolpman D, Olyaei A, et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg 2003;138:852-8.. PubMed
- Lambert JD, Zhao D, Meyers RO, et al. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 2002;40:1701-8.. PubMed
- Shasky DR. Contact dermatitis from Larrea tridentata (creosote bush). J Am Acad Dermatol 1986;15:302.. PubMed
- Smith AY, Feddersen RM, Gardner KD Jr, Davis CJ Jr. Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: a case report. J Urol 1994;152:2089-91.. PubMed
- Kauma, H., Koskela, R., Makisalo, H., Autio-Harmainen, H., Lehtola, J., and Hockerstedt, K. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand.J Gastroenterol. 2004;39(11):1168-1171. PubMed
- Leonforte, J. F. Contact dermatitis from Larrea (creosote bush). J Am Acad.Dermatol. 1986;14(2 Pt 1):202-207. PubMed
- Alderman, S., Kailas, S., Goldfarb, S., Singaram, C., and Malone, D. G. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin.Gastroenterol. 1994;19(3):242-247.
- Clark, F. Chaparral-induced toxic hepatitis: California and Texas, 1992. MMWR Morb Mortal Wkly Rep. 1992;41:812-814. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC