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Dietary supplement

Cascara Sargada Extract Powder Ingredients & Drug Interactions

by Herbadiet

Cascara Sargada Extract Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cascara Sargada Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cascara Sargada Extract Powder is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for constipation, bowel cleansing before procedures, hemorrhoids.Based on those ingredients, 745 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cascara sagrada Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cascara Sargada Extract Powder by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Cascara Sargada Extract Powder by Herbadiet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cascara Sargada Extract Powder by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cascara sagrada extract in powder form. Cascara sagrada is a stimulant laxative derived from the bark of a buckthorn shrub; it works by triggering bowel contractions to move stool through your colon.

There are no inactive ingredients listed for this product.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cascara Sagrada's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Natural laxative for digestive regularity.
  • We looked for evidence on: Constipation, Bowel preparation, Bowel motility, Intestinal function.
  • The closest evidence on file: Cascara Sagrada is rated "Possibly Ineffective" for Bowel preparation (Natural Medicines).
  • Also on file: Cascara Sagrada is rated "Insufficient Reliable Evidence To Rate" for Constipation.

The evidence for cascara sagrada is mixed. For bowel preparation (like before a medical procedure), it's rated possibly ineffective.

For everyday constipation, there isn't enough reliable evidence in our data to rate whether it actually works. If you're considering it for constipation, talk with your pharmacist or doctor about whether the short-term risks are worth any potential benefit in your situation.

The evidence, ingredient by ingredient Cascara Sagrada

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cascara sagrada is generally well tolerated when used short-term at appropriate doses — most people report only mild belly discomfort or cramps. The real caution comes with long-term use: it can lead to low potassium, protein in your urine (albuminuria), blood in your urine (hematuria), and muscle wasting (cachexia).

Very rarely, fresh or improperly aged cascara bark can trigger severe vomiting. Also, stimulant laxatives like cascara aren't recommended during pregnancy.

Active compounds can pass into breast milk, so it's best avoided while nursing.

Side effects, ingredient by ingredient Cascara Sagrada

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cascara Sagrada.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 746 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on water pills or corticosteroids (risk of low potassium), warfarin or other blood thinners (increased bleeding risk), digoxin or other heart medications (toxicity from low potassium), or any other stimulant laxatives (compounded fluid loss). Also mention any CYP3A4 substrates you're taking — your pharmacist can tell you if any of your drugs fall into that category.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cascara sagrada may help with short-term constipation, but it's not your first choice, especially if you take heart medications, blood thinners, water pills, or steroids. Long-term use carries real risks.

If you're thinking about it, check with your pharmacist first — they can tell you whether it's right for your medications and how long you can safely use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cascara Sargada Extract Powder, straight from the product label.

Brand Herbadiet
Net contents 0 Not Present
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 293535
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cascara Sargada Extract Powder by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
400 mg
Maximum serving Sizes:
800 mg
IngredientAmount% DV
Cascara sagrada Extract, Powder400 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural laxative

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

Being a natural produce, there can be minor color variations because of geographical & seasonal variation of the raw material. Herbal extracts can be hygroscopic & may agglomerate at times. This, in no way, affect the efficacy of the product.

V Vegan

Ethically sourced Scientifically tested Premium grade ingredients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take up to 800 mg, or as directed by your physician

Precautions

Keep out of reach of children.

Pregnant or lactating women should consult your physician before use.

Storage

Store in a dry, cool & dark.

FDA Disclaimer Statement

Warning: This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Batch No.: ARK/P/211

Seals/Symbols

FSSAI (Food Safety and Standards Authority of India) Lic. No.: 20817018000147

Formula

Standardized extract powder derived from rhamnus pushiana barks

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cascara Sargada Extract Powder by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cascara Sargada Extract Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cascara Sargada Extract Powder by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size400 mg Dosage formPowder Amounts shown are per serving.

Cascara sagrada Extract, Powder

Interacts with
745 drugs
400 mg per serving

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Becaus...

Cascara sagrada Extract, Powder monograph & interactions
Interaction report

Cascara Sargada Extract Powder by Herbadiet Drug Interactions

Want to check YOUR meds against Cascara Sargada Extract Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
745Drugs
122 Moderate 623 Minor

Ingredients driving the most interactions

Cascara sagrada Extract, Powder 745

Individual Drug Interactions

The ingredients in Cascara Sargada Extract Powder interact with 745 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cascara Sargada Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Cascara sagrada Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Cascara Sargada Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cascara sagrada Extract, Powder6 drug types · 745 drugs

Corticosteroids

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Cascara sagrada Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cascara Sargada Extract Powder, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Cascara Sargada Extract Powder by Herbadiet: Common Questions

Does Cascara Sargada Extract Powder by Herbadiet interact with any medications?
Yes. Based on its ingredients, Cascara Sargada Extract Powder has a known interaction with 745 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cascara Sargada Extract Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take cascara sagrada if I'm pregnant or breastfeeding?
Stimulant laxatives like cascara aren't recommended during pregnancy. If you're breastfeeding, it's best avoided — the active compounds can pass into breast milk. Talk with your doctor or pharmacist about safe alternatives if you need constipation relief.
What's the most common side effect I might notice?
Mild abdominal discomfort and cramps are the most common. These usually happen when you use the product short-term at the right dose. If cramping is severe or persistent, stop and talk with your pharmacist.
How long can I safely use cascara sagrada?
The safety data backs short-term use — that's when it's generally well tolerated. Long-term use raises the risk of serious effects like low potassium and changes to your urine. Your pharmacist can advise you on duration for your situation.
Does cascara actually work for constipation?
There isn't enough reliable evidence in our data to say whether it works for everyday constipation. For bowel prep before a medical procedure, it's rated possibly ineffective. Ask your pharmacist or doctor if it's the right choice for you.
What happens if I use cascara with a water pill or heart medication?
Cascara can lower your potassium levels, especially with long-term use. If you're on a water pill (diuretic), corticosteroid, or heart medication like digoxin, that low potassium becomes dangerous — it can cause irregular heartbeat and other serious effects. Always check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cascara Sargada Extract Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cascara Sargada Extract Powder label
Go deeper

The Full Monographs Behind Cascara Sargada Extract Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cascara Sagrada

Interacts with 745 drugs

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...

Read the full Cascara Sagrada monograph →
Sources

Sources & How We Checked

Cascara Sargada Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cascara Sagrada 9 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
  7. Nakasone ES, Tokeshi J. A serendipitous find: a case of cholangiocarcinoma identified incidentally after acute liver injury due to cascara sagrada ingestion. Hawaii J Med Public Health 2015;74(6):200-2.
  8. Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res 2015;29(10):1488-93. PubMed
  9. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Cascara Sagrada monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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