Cassia Ingredients & Drug Interactions
by doTERRA
What is this page for?
First and foremost: checking Cassia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cassia is a dietary supplement by doTERRA with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 442 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cassia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cassia by doTERRA
Ask about any prescription or over-the-counter medication and we check it for interactions with Cassia by doTERRA — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Cassia by doTERRA
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — Cassia Cinnamon.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: diabetes medications.
- For scale: 443 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cassia, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cassia by doTERRA, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cassia | 60 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
For aromatic or topical use.
Diffuse aromatically or, to apply topically, dilute with a carrier oil.
For internal use dilute one drop in 4 fl. oz. of liquid.
Precautions
Caution: Possible skin sensitivity.
Keep out of reach of children.
If pregnant or under a doctor's care, consult your physician.
Avoid contact with eyes, inner ears, and sensitive areas.
General
v6 30270001
Formula
Cinnamomum cassia
FDA Statement of Identity
Essential Oil Supplement
Brand IP Statement(s)
CPTG Certified Pure Therapeutic Grade
General Statements
Peel back for more information.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cassia by doTERRA label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cassia by doTERRA
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Drop(s) Dosage formLiquid Servings per container85 Amounts shown are per serving.
Cassia
Interacts with442 drugs
Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...
Cassia monograph & interactionsCassia by doTERRA Drug Interactions
Cassia contains a single active ingredient, and it has known interactions with 442 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Cassia?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cassia interact with 442 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cassia interact with drugs. Each result below shows which ingredient is responsible. Cassia
Asparaginase Erwinia Chrysanthemi (recombinant)-rywnRylaze
How Asparaginase Erwinia Chrysanthemi (recombinant)-rywn interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Asparaginase Erwinia Chrysanthemi (recombinant)-rywn interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Atorvastatin Calcium interactionAvacopanTavneos
How Avacopan interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Avacopan interactionAzamuneImmunoprin
How Azamune interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Azathioprine interactionBaricitinibOlumiant
How Baricitinib interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Baricitinib interactionBelinostatBeleodaq
How Belinostat interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Belinostat interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Benzhydrocodone, Acetaminophen interactionBimekizumab-bkzxBimzelx
How Bimekizumab-bkzx interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Bimekizumab-bkzx interactionBinimetinibMektovi
How Binimetinib interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Binimetinib interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBortezomibVelcade
How Bortezomib interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Bortezomib interactionBosentanTracleer
How Bosentan interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Bosentan interactionBosutinibBosulif
How Bosutinib interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Bosutinib interactionCanagliflozinInvokana
How Canagliflozin interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cassia + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cassia + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cassia + Canagliflozin, Metformin Hydrochloride interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Cannabidiol (prescription Drug) interactionCapmatinib HydrochlorideTabrecta
How Capmatinib Hydrochloride interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Capmatinib Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Carbamazepine interactionCarbenicillin Indanyl SodiumGeocillin
How Carbenicillin Indanyl Sodium interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Carbenicillin Indanyl Sodium interactionCarbimazoleNeo-Mercazole
How Carbimazole interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Carbimazole interactionCarfilzomibKyprolis
How Carfilzomib interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Carfilzomib interactionCeritinibZykadia
How Ceritinib interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Ceritinib interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Cerivastatin Sodium interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Chlorothiazide, Methyldopa interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Chlorpropamide interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Cassia — through 1 ingredient. Tap an ingredient for the detail:
CassiaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia + Chlortetracycline interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cassia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cassia
Antidiabetes Drugs
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.
Hepatotoxic Drugs
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.
Brand information
Manufacturer and brand details for Cassia, from the product label.
doTERRA
See all doTERRA products- Name
- doTERRA Intl, LLC
- Street Address
- 389 South 1300 West
- City
- Pleasant Grove
- State
- UT
- ZipCode
- 84062
Cassia by doTERRA: Common Questions
Does Cassia by doTERRA interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cassia is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cassia’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cassia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cassia Cinnamon 20 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
- De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
- Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
- Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
- Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
- Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
- Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
- Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
- Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
- Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
- Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
- Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
- Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
- Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
- Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC