Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Certified Organic Uva Ursi Leaf Ingredients & Drug Interactions

by Gaia Organics

Certified Organic Uva Ursi Leaf label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Certified Organic Uva Ursi Leaf against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Certified Organic Uva Ursi Leaf is a dietary supplement by Gaia Organics with 3 active ingredients. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Uva Ursi leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Certified Organic Uva Ursi Leaf by Gaia Organics

Ask about any prescription or over-the-counter medication and we check it for interactions with Certified Organic Uva Ursi Leaf by Gaia Organics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Certified Organic Uva Ursi Leaf by Gaia Organics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

Gaia Organics' Certified Organic Uva Ursi Leaf is a liquid extract with 3 ingredients: water, organic grain alcohol (the extraction solvent), and organic uva ursi leaf extract, which is the active component. There are no other inactive fillers or binding agents in this product.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract health.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, kidney health, diuretic support.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for uva ursi's effectiveness is mixed and limited. For urinary tract infections (UTIs), the data suggests it's possibly ineffective — meaning the current evidence doesn't support using it for that purpose.

For bronchitis and benign prostatic hyperplasia (BPH), there isn't enough reliable evidence in our data to rate whether it works or not. If you're considering this supplement for a specific health concern, ask your pharmacist what the current research suggests for your situation.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated at low doses for short-term use, but it carries real safety limits. The most common side effects are diarrhea, nausea, stomach upset, and vomiting.

At very high doses — around 20 grams of dried herb or more — it can cause serious effects like convulsions, confusion, shortness of breath, and even collapse; doses of 30 grams or more may be fatal. Uva ursi is likely unsafe during pregnancy because it may stimulate the uterus and lacks adequate safety data.

There isn't enough information to know if it's safe while breastfeeding, so it's best to avoid it then as well. Keep this to short-term use only, and never exceed recommended doses.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take medications broken down by your liver's CYP2C19 or CYP3A4 enzymes (many heart, psychiatric, and cancer drugs fall here — Moderate severity), lithium for mood disorders (Moderate), glucuronidated drugs (Moderate), or urinary acidifying agents (Moderate). These are the main ones to verify.

Use the search tool on this page with your exact medication names to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi is an old herbal remedy, but evidence for its effectiveness is weak and its safety requires careful dosing and timing. If you take any prescription medications — especially those for mood, heart, or liver function — talk with your pharmacist before adding this.

Pregnant or breastfeeding? Skip it.

Short-term use in standard doses is generally okay for otherwise healthy people, but this isn't a supplement to take casually or long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Certified Organic Uva Ursi Leaf, straight from the product label.

Brand Gaia Organics
Barcode (UPC) 751063311502
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Apr 25, 2013
DSLD ID 16501
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Certified Organic Uva Ursi Leaf by Gaia Organics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.33 mL
Maximum serving Sizes:
2 mL
Servings per container
23
UPC/BARCODE
751063311502
IngredientAmount% DV
Water0 NP--
organic Grain Alcohol0 NP--
organic Uva Ursi leaf extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

[04] 1201-0910

General Statements

400 mg/ml herb equivalency

Liquid Herbal Extract

Formulation

Certified Organic by Oregon Tilth

CERTIFIED ORGANIC

Precautions

Use only as directed on label. Safety sealed for your protection.

Not to be used during pregnancy or lactation. If you have a medical condition or take pharmaceutical drugs, please consult with your doctor before use.

Keep away from children.

Seals/Symbols

USDA ORGANIC

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use Take 40-60 drops of extract in a small amount of water 3 times daily between meals. Shake well before using.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Certified Organic Uva Ursi Leaf by Gaia Organics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Certified Organic Uva Ursi Leaf label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Certified Organic Uva Ursi Leaf by Gaia Organics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.33 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Water

0 NP per serving

Organic Grain Alcohol

0 NP per serving

Organic Uva Ursi leaf extract

Interacts with
803 drugs
0 NP per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Organic Uva Ursi leaf extract monograph & interactions
Interaction report

Certified Organic Uva Ursi Leaf by Gaia Organics Drug Interactions

Want to check YOUR meds against Certified Organic Uva Ursi Leaf?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

organic Uva Ursi leaf extract 803

Individual Drug Interactions

The ingredients in Certified Organic Uva Ursi Leaf interact with 803 drugs. Click any drug to see the details.

1 of the 3 ingredients in Certified Organic Uva Ursi Leaf interact with drugs. Each result below shows which ingredient is responsible. organic Uva Ursi leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Certified Organic Uva Ursi Leaf with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Uva Ursi leaf extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
organic Uva Ursi leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Certified Organic Uva Ursi Leaf, from the product label.

Gaia Organics

See all Gaia Organics products
Web Address
GaiaHerbs.com
Pharmacist Counseling Corner

Certified Organic Uva Ursi Leaf by Gaia Organics: Common Questions

Does Certified Organic Uva Ursi Leaf by Gaia Organics interact with any medications?
Yes. Based on its ingredients, Certified Organic Uva Ursi Leaf has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Certified Organic Uva Ursi Leaf contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is uva ursi supposed to do?
Uva ursi has traditionally been used for urinary tract infections and other conditions, but the evidence that it actually works for UTIs is weak — it's rated possibly ineffective for that purpose. For bronchitis and prostate issues, we don't have enough research data to say whether it helps.
Can I take this while pregnant or breastfeeding?
No — uva ursi is likely unsafe in pregnancy because it may stimulate the uterus and we don't have enough safety data. There also isn't enough information to know if it's safe while breastfeeding, so you should avoid it then too.
What are the side effects?
At normal doses, the most common side effects are diarrhea, nausea, stomach upset, and vomiting. At very high doses (20 grams or more of the dried herb), serious effects like convulsions, confusion, and shortness of breath can occur. Doses of 30 grams or more may be fatal.
How long can I take this?
Uva ursi is meant for short-term use only. It can be toxic in high doses or with prolonged use, so don't take it long-term without your doctor's oversight.
Does this interact with my medications?
Uva ursi may slow how your liver breaks down certain medications and could affect lithium levels, among other interactions. Use the medication checker on this page to search your exact prescriptions — it's the fastest way to know for sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Certified Organic Uva Ursi Leaf is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Certified Organic Uva Ursi Leaf label
Go deeper

The Full Monographs Behind Certified Organic Uva Ursi Leaf’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Certified Organic Uva Ursi Leaf's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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