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Dietary supplement

Chaga Mushroom Extract Capsules 500 mg Ingredients & Drug Interactions

by Nootropics Depot

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Chaga Mushroom Extract Capsules 500 mg is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for immune support, antioxidant support, general wellness/tonic.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Inonotus obliquus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Inonotus obliquus, a fungus commonly called chaga, at 500 mg per capsule. It also includes two inactive ingredients — magnesium stearate and vegetable cellulose — which help form and preserve the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Chaga product and its label doesn't state a use — see Chaga's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for chaga's effectiveness is thin across the board. The data we hold rates it as having insufficient reliable evidence for cardiovascular disease, diabetes, and COVID-19.

That doesn't mean it doesn't work — it means the research backing for those uses isn't solid enough yet to draw firm conclusions. If you're considering this for one of those reasons, talk it over with your doctor about what the current science actually shows.

The evidence, ingredient by ingredient Chaga

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chaga is generally used in foods and teas, but human safety data are limited. The main reported risk is kidney trouble — there have been two cases of kidney failure and one case of kidney inflammation (acute nephropathy) tied to heavy chaga use, likely because chaga contains high levels of oxalate, a compound that can stress the kidneys.

If you have kidney problems or a history of kidney stones, this is something to discuss with your doctor. For pregnancy and breastfeeding, there isn't enough safety information to know either way, so the advice is to avoid it during those times.

Talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Chaga

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chaga.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin) — chaga may theoretically increase bleeding risk. Also flag immunosuppressants and any diabetes medication, as chaga might interfere with how they work.

No interactions are documented for other medication types in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Chaga extract is a single-ingredient supplement with no established track record of effectiveness for its most common uses. The main concern is interactions with blood thinners, immune-suppressing drugs, and diabetes medications — all of which are theoretical and unconfirmed in humans, but serious enough to warrant a check.

If you take any of those drug types, or have kidney issues, clear it with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chaga Mushroom Extract Capsules 500 mg, straight from the product label.

Brand Nootropics Depot
Net contents 15 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232092
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
15
IngredientAmount% DV
Inonotus obliquus500 mg--

Other ingredients: Magnesium Stearate, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Beta-glucan minimum content: 8%

FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Formulation

Non GMO

USDA Organic

Seals/Symbols

USDA Organic

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 capsule 1-2 times daily.

See for yourself

Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Inonotus obliquus

Interacts with
327 drugs
500 mg per serving

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Inonotus obliquus monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot Drug Interactions

Want to check YOUR meds against Chaga Mushroom Extract Capsules 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Chaga Mushroom Extract Capsules 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Inonotus obliquus3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Chaga Mushroom Extract Capsules 500 mg, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot: Common Questions

Does Chaga Mushroom Extract Capsules 500 mg by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Chaga Mushroom Extract Capsules 500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chaga Mushroom Extract Capsules 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is chaga safe in pregnancy?
There isn't enough safety data to say either way. The advice is to avoid it during pregnancy. If you're pregnant or planning to be, talk with your doctor or pharmacist before taking it.
Can I take this if I'm breastfeeding?
There isn't enough safety information available. It's recommended to avoid chaga while breastfeeding. Check with your doctor or pharmacist for personalized advice.
What does chaga actually do?
The evidence for chaga's effectiveness isn't solid enough yet for us to say it works for cardiovascular disease, diabetes, or COVID-19 — the main uses people ask about. If you're interested in it for one of those reasons, your doctor can help you weigh whether to try it.
Are there side effects from chaga?
Most people tolerate it without issue, but there have been reports of kidney failure and kidney inflammation linked to very high chaga intake due to its high oxalate content. If you have kidney disease or a history of kidney stones, talk with your doctor first.
Is this just chaga, or are there other ingredients?
It's just 500 mg of chaga per capsule. The capsule itself contains magnesium stearate and vegetable cellulose, which are inactive ingredients that help hold it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chaga Mushroom Extract Capsules 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chaga Mushroom Extract Capsules 500 mg label
Go deeper

The Full Monographs Behind Chaga Mushroom Extract Capsules 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Chaga Mushroom Extract Capsules 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chaga 9 references
  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
  2. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
  3. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
  4. Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
  5. Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
  6. Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
  7. Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
  8. Chen S, Ma Y, Li H, et al. Anti-diabetic e?ects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice. Nutr Hosp 2022;39(6):1256-1263. PubMed
  9. Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Front Endocrinol (Lausanne) 2023;13:1103972. PubMed

See these in context on the Chaga monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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