Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Chaste Tree Berry Ingredients & Drug Interactions

by Mountain Meadow Herbs

Chaste Tree Berry label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chaste Tree Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chaste Tree Berry is a dietary supplement by Mountain Meadow Herbs with 3 active ingredients. Its ingredients are commonly taken for premenstrual syndrome (pms), irregular or absent menstrual periods, cyclical breast pain (mastalgia).Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaste Tree berry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chaste Tree Berry by Mountain Meadow Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Chaste Tree Berry by Mountain Meadow Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chaste Tree Berry by Mountain Meadow Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.

This liquid supplement contains three ingredients: distilled water, organic grain alcohol, and chaste tree berry extract (vitex agnus-castus). The active ingredient is the vitex extract, which has been used traditionally to support menstrual and hormonal wellness.

The water and grain alcohol are inactive ingredients that carry and preserve the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Vitex Agnus-castus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Vitex Agnus-castus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Mastalgia — rated "Possibly Effective" (Natural Medicines).
  • On file: Premenstrual syndrome (PMS) — rated "Possibly Effective" (Natural Medicines).

The chaste tree berry extract in this product has some established support for premenstrual syndrome (PMS) and breast tenderness (mastalgia)—both rated possibly effective. For other uses like fractures, aging skin, premenstrual dysphoric disorder (PMDD), and anxiety, the evidence we have is either insufficient to rate or suggests possible ineffectiveness.

If you're considering this for PMS or breast tenderness, talk with your doctor about whether the evidence fits your situation.

The evidence, ingredient by ingredient Vitex Agnus-castus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitex agnus-castus is generally well tolerated for short-term use. Common side effects reported in studies include diarrhea, fatigue, headache, insomnia, irregular menstruation, nausea, stomach pain, vomiting, and skin irritation (itching, rash, acne, eczema, or hair loss).

Because vitex may affect hormones, you should use it under guidance from your doctor or pharmacist. The safety data advises against using this product during pregnancy or while breastfeeding due to possible hormonal effects and limited safety information in these situations.

Side effects, ingredient by ingredient Vitex Agnus-castus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitex Agnus-castus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take dopamine-related medications (metoclopramide, antipsychotics, or dopamine agonists) or hormonal medications (oral contraceptives or estrogen-based hormone replacement therapy). Vitex has Moderate interactions with all of these, and it may reduce how well they work.

Use the medication checker on this page to confirm your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Chaste Tree Berry may be worth considering if you're exploring natural support for PMS or breast tenderness and have talked it over with your doctor. If you take any hormonal medications (like birth control or hormone replacement therapy) or dopamine-related drugs (like antipsychotics or metoclopramide), you'll need to check with your doctor or pharmacist first—this supplement could interfere with how they work.

Before you start, make sure your healthcare provider knows about all your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chaste Tree Berry, straight from the product label.

Brand Mountain Meadow Herbs
Barcode (UPC) 813086015123
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 267512
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult Female (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chaste Tree Berry by Mountain Meadow Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
48
UPC/BARCODE
813086015123
IngredientAmount% DV
Water, Distilled0 NP--
organic Grain Alcohol0 NP--
Chaste Tree berry extract1.25 mL--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Vitex angus-castus

Centuries-old health support for women Female health support

Formulation

Hand-made extract

GF (Gluten free) Sugar free

Vegan

Promotes healthy hormone balance Menstruation support

FDA Statement of Identity

Herbal Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 12+ yrs: 1/4 tsp. Take in water 1-3 times daily.

Shake well.

Precautions

Caution: If you are pregnant, nursing, have a medical condition, or are taking a prescription, consult your health care provider before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place out of sunlight.

Seals/Symbols

Made in Montana USA

General Statements

1 dropperful = approx. 1/8 tsp.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chaste Tree Berry by Mountain Meadow Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chaste Tree Berry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chaste Tree Berry by Mountain Meadow Herbs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 tsp Dosage formLiquid Servings per container48 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Water, Distilled

0 NP per serving

Organic Grain Alcohol

0 NP per serving

Chaste Tree berry extract

Interacts with
121 drugs
1.25 mL per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chaste Tree berry extract monograph & interactions
Interaction report

Chaste Tree Berry by Mountain Meadow Herbs Drug Interactions

Want to check YOUR meds against Chaste Tree Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Chaste Tree berry extract 121

Individual Drug Interactions

The ingredients in Chaste Tree Berry interact with 121 drugs. Click any drug to see the details.

1 of the 3 ingredients in Chaste Tree Berry interact with drugs. Each result below shows which ingredient is responsible. Chaste Tree berry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Chaste Tree Berry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chaste Tree berry extract5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chaste Tree berry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chaste Tree Berry, from the product label.

Mountain Meadow Herbs

See all Mountain Meadow Herbs products
Name
Mountain Meadow Herbs, Inc.
Street Address
1019 Hard Rock Rd
City
Somers
State
MT
ZipCode
59932
Phone Number
888.528.8615
Web Address
www.mmherbs.com
Pharmacist Counseling Corner

Chaste Tree Berry by Mountain Meadow Herbs: Common Questions

Does Chaste Tree Berry by Mountain Meadow Herbs interact with any medications?
Yes. Based on its ingredients, Chaste Tree Berry has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chaste Tree Berry contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Vitex agnus-castus has a documented Moderate interaction with oral contraceptives—it may interfere with how well they work. You should talk with your doctor or pharmacist before using this product alongside birth control to decide if it's right for you.
Is this safe during pregnancy or breastfeeding?
No. The safety data rates vitex as possibly unsafe in pregnancy due to possible hormonal effects and limited safety information. It's also not recommended while breastfeeding because it may influence milk-related hormones and safety is unclear. Talk with your doctor before using this during either period.
What are the most common side effects?
The most frequently reported side effects are diarrhea, fatigue, headache, insomnia, irregular menstruation, nausea, stomach pain, and vomiting. Skin irritation (rash, itching, acne, eczema) and hair loss have also been reported. Most people tolerate it well for short-term use, but if side effects bother you, talk with your pharmacist.
Does this really work for PMS?
Vitex agnus-castus is rated possibly effective for premenstrual syndrome and breast tenderness based on available evidence. That means there's some research support, but it's not definitive. If you're thinking about trying it, talk with your doctor about whether it's a good fit for your symptoms.
Why does this contain grain alcohol?
The organic grain alcohol is an inactive ingredient that helps preserve and deliver the chaste tree berry extract in liquid form. If you need to avoid alcohol, check the label for the exact percentage or talk with your pharmacist about alternatives.
Can I take this with hormone replacement therapy?
Vitex has a documented Moderate interaction with estrogen-based hormone replacement therapy—it may reduce how well those medications work. Check with your doctor or pharmacist before adding this supplement if you're on HRT.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chaste Tree Berry label
Go deeper

The Full Monographs Behind Chaste Tree Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph →
Sources

Sources & How We Checked

Chaste Tree Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitex Agnus-castus 23 references
  1. Wuttke W. Dopaminergic action of extracts of Agnus Castus. Forschende Komplementarmedizen 1996;3:329-30.
  2. Jarry H, Leonhardt S., Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus Castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 1994;102:448- PubMed
  3. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo-controlled study. BMJ 2001;322:134-7. PubMed
  4. Lauritzen CH, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled-double blind versus pyridoxine. Phytomedicine 1997;4:183-9.
  5. Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet 2000;264:150-3.
  6. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000;9:315-20. PubMed
  7. Meier B, Berger D, Hoberg E, et al. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000;7:373-81. PubMed
  8. Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. PubMed
  9. Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003;10:348-57. PubMed
  10. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5..
  11. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005;28:319-32..
  12. Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast 1999;8:175-81. PubMed
  13. Prilepskaya VN, Ledina AV, Tagiyeva AV, Revazova FS. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas 2006;55 Suppl 1:S55-63. DOI
  14. Ma, L., Lin, S., Chen, R., and Wang, X. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol.Endocrinol. 2010;26(8):612-616. PubMed
  15. Ma, L., Lin, S., Chen, R., Zhang, Y., Chen, F., and Wang, X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust.N.Z.J Obstet.Gynaecol. 2010;50(2):189-193. PubMed
  16. Dinç T, Coskun F. Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women. Ulus Cerrahi Derg. 2014 Mar 1;30(1):34-8 PubMed
  17. Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai K. Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study. Adv Ther. 2014 Mar;31(3):362-73. PubMed
  18. Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013 Aug 31;2(3):245-54.
  19. Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
  20. Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
  21. Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
  22. Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
  23. Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed

See these in context on the Vitex Agnus-castus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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