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Dietary supplement

Chem-Defense Orange Flavored Ingredients & Drug Interactions

by Source Naturals

Chem-Defense Orange Flavored label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chem-Defense Orange Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chem-Defense Orange Flavored is a dietary supplement by Source Naturals with 3 active ingredients. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chem-Defense Orange Flavored by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Chem-Defense Orange Flavored by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chem-Defense Orange Flavored by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Riboflavin” is listed as a grouped ingredient — the label gives one combined amount (1.60 mg) without saying how much of each component you get.

This 3-ingredient supplement contains molybdenum (a mineral), riboflavin (vitamin B2), and L-glutathione and flavin mononucleotide (both compounds involved in cellular energy and antioxidant function). The tablet also includes sorbitol, mannitol, natural orange flavor, and magnesium stearate as inactive ingredients to hold the formula together and improve taste.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support for chemical sensitivities.
  • We looked for evidence on: Molybdenum deficiency, Sulfite sensitivity, Chemical sensitivities, Detoxification support.
  • The strongest evidence on file: Molybdenum is rated "Likely Effective" for Molybdenum deficiency (Natural Medicines).

Molybdenum is likely effective for treating molybdenum deficiency, though deficiency is rare in people eating a typical diet. The evidence for the other purposes listed—acne, iron-deficiency anemia, asthma, osteoporosis, and esophageal cancer—is insufficient to rate.

We don't have effectiveness ratings on file for L-glutathione or flavin mononucleotide in this data.

The evidence, ingredient by ingredient Riboflavin Molybdenum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Molybdenum is generally well tolerated when taken in appropriate amounts; the recommended upper limit is 2 mg per day. The safety notes caution that high-dose supplements may cause problems and are rarely necessary—dietary amounts and prenatal vitamins are fine, but high-dose supplements should be avoided unless your doctor advises otherwise.

Rare adverse effects from excess molybdenum include contact allergies (in people with certain stents) and, in one case report, severe neurological symptoms at very high doses. We don't have pregnancy or breastfeeding safety data on file for this product.

Side effects, ingredient by ingredient Riboflavin Molybdenum

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for the ingredients we could check in our data. However, we couldn't verify L-glutathione and flavin mononucleotide against medications, so check your exact drug names with the tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This is a low-risk supplement for molybdenum deficiency if your doctor confirms you need it. If you take any medications or have concerns about the high-dose safety notes, talk to your pharmacist or doctor before starting—especially if you're pregnant or breastfeeding, since we don't have specific safety data for those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chem-Defense Orange Flavored, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078002451
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 295624
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chem-Defense Orange Flavored by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
90
UPC/BARCODE
021078002451
IngredientAmount% DV
Riboflavin1.6 mg94%
L-Glutathione50 mg--
Total Carbohydrate1 Gram(s)1%
Molybdenum120 mcg160%
Flavin Mononucleotide2.25 mg--

Other ingredients: Sorbitol, Mannitol, natural Orange flavor, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Molybdenum/glutathione complex Orange flavored sublingual

Chem-Defense is a nutrient blend formulated for persons with chemical sensitivities. Recent scientific research indicates that molybdenum, a trace mineral which activates the enzymes aldehyde oxidase and sulfite oxidase, may provide necessary nutritional support for chemically sensitive individuals. Glutathione (GSH) is a key element of the liver's detoxifying process, and is also the precursor for glutathione peroxidase, a major free radical-scavenging enzyme. Riboflavin is the precursor for FAD, a coenzyme which recycles used GSH.

Precautions

Contains soy.

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 to 3 tablets daily. Place tablet under the tongue and allow to dissolve slowly, altering its position to avoid prolonged contact with the same area.

Formulation

The sublingual form is absorbed directly into the bloodstream, via the blood vessels under the tongue and in the cheeks, allowing for quick entry into the system.

Suitable for vegetarians.

Contains no dairy, egg, gluten or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright Source Naturals, INC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chem-Defense Orange Flavored by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chem-Defense Orange Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chem-Defense Orange Flavored by Source Naturals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Riboflavin

Interacts with
20 drugs
1.6 mg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions
  • › Flavin Mononucleotide

L-Glutathione

50 mg per serving

Molybdenum

No known
interactions
120 mcg per serving Form: Molybdenum Chelate

Molybdenum is an essential trace mineral your body needs in tiny amounts to help certain enzymes work. Most people get enough from a normal diet, so s...

Molybdenum monograph & interactions

Other (inactive) ingredients: Sorbitol, Mannitol, Natural Orange flavor, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chem-Defense Orange Flavored by Source Naturals Drug Interactions

Want to check YOUR meds against Chem-Defense Orange Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in Chem-Defense Orange Flavored interact with 20 drugs. Click any drug to see the details.

1 of the 3 ingredients in Chem-Defense Orange Flavored interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Chem-Defense Orange Flavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chem-Defense Orange Flavored, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Chem-Defense Orange Flavored by Source Naturals: Common Questions

Does Chem-Defense Orange Flavored by Source Naturals interact with any medications?
Yes. Based on its ingredients, Chem-Defense Orange Flavored has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chem-Defense Orange Flavored contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is molybdenum and why is it in this supplement?
Molybdenum is a mineral your body needs in tiny amounts to help certain enzymes work. This supplement provides it if your diet is short on molybdenum-containing foods like legumes, grains, and nuts—though deficiency is uncommon in people eating a normal diet.
Is there a maximum amount of molybdenum I should take?
Yes. The recommended upper limit is 2 mg per day. High-dose supplements beyond that are rarely necessary and may cause problems. Dietary amounts and prenatal vitamins are fine; just avoid extra high-dose supplements unless your doctor says otherwise.
What are L-glutathione and flavin mononucleotide supposed to do?
Both are compounds involved in cellular energy production and antioxidant protection. We don't have specific effectiveness ratings on file for them in this data, so we can't tell you how well they work for any particular purpose.
Is this safe if I'm pregnant or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for this product. Talk to your doctor or pharmacist for personalized advice—especially about molybdenum doses, since the safety notes emphasize not taking high-dose supplements without medical guidance in those situations.
What are the side effects of molybdenum?
At normal amounts, molybdenum is generally well tolerated. Rare adverse effects have been reported at very high doses or in people with certain medical stents. If you experience unusual symptoms, talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chem-Defense Orange Flavored label
Go deeper

The Full Monographs Behind Chem-Defense Orange Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Molybdenum

Molybdenum is an essential trace mineral your body needs in tiny amounts to help certain enzymes work. Most people get enough from a normal diet, so supplements are rarely needed unless a do...

Read the full Molybdenum monograph →
Sources

Sources & How We Checked

Chem-Defense Orange Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Molybdenum 8 references
  1. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Rajagopalan KV. Molybdenum: an essential trace element in human nutrition. Annu Rev Nutr 1988;8:401-27. PubMed
  4. Selden AI, Berg NP, Soderbergh A, Bergstrom BE. Occupational molybdenum exposure and a gouty electrician. Occup Med (Lond) 2005;55:145-8. PubMed
  5. Al-Saleh E, Nandakumaran M, Al-Shammari M, Al-Harouny A. Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in patients with gestational diabetes. J Matern Fetal Neonatal Med 2004;16:15-21. PubMed
  6. Koster R, Vieluf D, Kiehn M, et al. Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis. Lancet 2000;356:1895-7. PubMed
  7. Vyskocil A, Viau C. Assessment of molybdenum toxicity in humans. J Appl Toxicol 1999;19:185-92. DOI
  8. Momcilovic, B. A case report of acute human molybdenum toxicity from a dietary molybdenum supplement--a new member of the "Lucor metallicum" family. Arh.Hig.Rada Toksikol. 1999;50(3):289-297. DOI

See these in context on the Molybdenum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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