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Dietary supplement

ChlorOxygen Chlorophyll Concentrate Softgels Ingredients & Drug Interactions

by Herbs Etc.

ChlorOxygen Chlorophyll Concentrate Softgels label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ChlorOxygen Chlorophyll Concentrate Softgels against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ChlorOxygen Chlorophyll Concentrate Softgels is a dietary supplement by Herbs Etc. with 3 active ingredients. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 499 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyll, Sodium, Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc.

Ask about any prescription or over-the-counter medication and we check it for interactions with ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc. — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ChlorOxygen Chlorophyll Concentrate Softgels contains 3 active ingredients. Copper supports normal metabolism and is used to treat copper deficiency, though evidence suggests it may not help with Alzheimer's disease.

Sodium is an essential mineral that regulates fluid balance and nerve function, and the product also supplies chlorophyll, the green pigment from plants, which is included for its purported health benefits—though evidence for most uses is still insufficient. The softgels also contain several inactive ingredients: bovine gelatin (the capsule shell), glycerin, purified water, carob, extra virgin olive oil, maltodextrin, and beeswax.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: blood support.
  • We looked for evidence on: Copper deficiency, Red blood cell formation, Hemoglobin synthesis, Anemia.
  • The strongest evidence on file: Copper is rated "Likely Effective" for Copper deficiency (Natural Medicines).
  • Also on file: Copper is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced anemia.

The evidence for each ingredient is mixed. Copper is likely effective for treating copper deficiency but is possibly ineffective for Alzheimer's disease.

For acne, chemotherapy-induced anemia, and brain tumors, the evidence we hold is insufficient to make a rating. Sodium's effectiveness is rated for specific medical conditions like cystic fibrosis (likely effective) and amphotericin B kidney toxicity (possibly effective), but the evidence is insufficient for bipolar disorder and heart failure.

Chlorophyll has not yet accumulated reliable evidence for the conditions listed in our data—genital herpes, wound healing, shingles, skin cancer, and pancreatitis are all marked insufficient evidence to rate.

The evidence, ingredient by ingredient Copper Sodium Chlorophyll

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Copper is generally well tolerated in amounts found in food and standard supplements, but excess copper is toxic. Contact dermatitis from copper has been reported rarely, and there's some evidence that people with diabetes tend to have higher blood copper levels, though it's unclear if elevated copper contributes to diabetes itself.

Sodium is fine in normal dietary amounts but can strain your heart and raise blood pressure at high intakes; serious adverse effects like worsened cardiovascular disease and kidney disease are rare but possible with excess. Chlorophyll is generally well tolerated in short-term use, but high-quality long-term safety data are limited.

The most common adverse effect is photosensitization—increased sensitivity to sun exposure—and rare cases of pseudoporphyria (a blistering condition) have been reported. For pregnancy, there isn't enough reliable safety data on chlorophyll to recommend it, and safety during breastfeeding is unknown, so talk with your doctor or pharmacist before use if you're pregnant or nursing.

Copper is needed in pregnancy but only in recommended amounts; avoid high-dose copper supplements unless your doctor advises it. Sodium's safety in pregnancy and lactation is conflicting in our data—some ratings suggest it's likely safe while others suggest possible unsafety—so discuss your individual situation with your healthcare provider.

Side effects, ingredient by ingredient Copper Sodium Chlorophyll

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Chlorophyll, Copper, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 499 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any of these: penicillamine (a Moderate interaction with copper), blood pressure medications, corticosteroids, lithium, didanosine, methotrexate, or any photosensitizing drugs (ones that increase sun sensitivity). Also flag any sodium-containing drugs or supplements.

If you're unsure whether your medications are affected, use the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you have copper deficiency and no contraindications, but it carries significant interactions with common medications, especially blood pressure drugs, lithium, methotrexate, and penicillamine. If you take any prescription medication, high blood pressure, heart disease, kidney disease, or are pregnant or breastfeeding, talk to your pharmacist or doctor before starting.

The sodium and chlorophyll content can interact with numerous drugs, so a medication check is essential.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ChlorOxygen Chlorophyll Concentrate Softgels, straight from the product label.

Brand Herbs Etc.
Barcode (UPC) 765704519219
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 320829
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
UPC/BARCODE
765704519219
IngredientAmount% DV
Copper2 mg100%
Sodium4 mg1%
Chlorophyll50 mg--

Other ingredients: Bovine Gelatin, Glycerin, Water, Purified, Carob, Chlorophyll, Extra Virgin Olive Oil, Maltodextrin, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Value size #1 seller SPINS data

We apply our company philosophy to ChlorOxygen Chlorophyll Concentrate, as we do to all of our herbal medicines. That philosophy is to do what's right, which extends to choosing the right herbs, using the right processes, and making the right formulations that support your health needs. We do all of this to bring you herbal medicines made right.

Formulation

Herbal medicine Traditionally used for blood support

Gluten free

Manufactured in Santa Fe, NM.

No artificial preservatives.

FDA Statement of Identity

Herbal Supplement

Formula

ChlorOxygen Chlorophyll Concentrate is made with blood-supporting sodium copper chlorophyllin, derived from European Fescue leaf chlorophyll.

Suggested/Recommended/Usage/Directions

Suggested use: Take one softgel with water twice a day.

Precautions

Note: Dark green stools may occur. Caution: Permanently stains.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ChlorOxygen Chlorophyll Concentrate Softgels label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc.

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Copper

Interacts with
31 drugs
2 mg per serving

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Sodium

Interacts with
205 drugs
4 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Chlorophyll

Interacts with
337 drugs
50 mg per serving Form: Sodium Copper Chlorophyllin

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reduc...

Chlorophyll monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Glycerin, Water, Purified, Carob, Chlorophyll, Extra Virgin Olive Oil, Maltodextrin, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc. Drug Interactions

Want to check YOUR meds against ChlorOxygen Chlorophyll Concentrate Softgels?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
499Drugs
469 Moderate 30 Minor

Ingredients driving the most interactions

Chlorophyll 337
Sodium 205
Copper 31

Individual Drug Interactions

The ingredients in ChlorOxygen Chlorophyll Concentrate Softgels interact with 499 drugs. Click any drug to see the details.

3 of the 3 ingredients in ChlorOxygen Chlorophyll Concentrate Softgels interact with drugs. Each result below shows which ingredient is responsible. Chlorophyll Sodium Copper

Each ingredient & the kinds of drugs it affects

For each ingredient in ChlorOxygen Chlorophyll Concentrate Softgels with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorophyll2 drug types · 337 drugs

Methotrexate (Trexall, Others)

Theoretically, chlorophyll may reduce the clearance of methotrexate.
In one case report, a 54-year-old male developed delayed clearance of intravenous high-dose methotrexate with concomitant use of chlorophyll. When chlorophyll was stopped 2 days prior to methotrexate treatment, methotrexate clearance was unaffected.

Likelihood Possible Evidence B
Photosensitizing Drugs

Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Chlorophyll has been reported to cause photosensitization. In two case reports, pseudoporphyria developed after oral intake of chlorophyll. Theoretically, concomitant use with other photosensitizing drugs may exacerbate this effect.

Likelihood Probable Evidence B
Chlorophyll full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ChlorOxygen Chlorophyll Concentrate Softgels, from the product label.

Herbs Etc.

Name
Herbs, Etc., Inc.
Street Address
1340 Rufina Circle
City
Santa Fe
State
NM
ZipCode
87507
Web Address
www.herbsetc.com
Pharmacist Counseling Corner

ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc.: Common Questions

Does ChlorOxygen Chlorophyll Concentrate Softgels by Herbs Etc. interact with any medications?
Yes. Based on its ingredients, ChlorOxygen Chlorophyll Concentrate Softgels has a known interaction with 499 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ChlorOxygen Chlorophyll Concentrate Softgels contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is chlorophyll, and why is it in this product?
Chlorophyll is the green pigment plants use to absorb sunlight. It's included in this supplement for its purported health benefits, though rigorous evidence for most conditions hasn't been established in our data.
Can I take this if I'm pregnant or breastfeeding?
The safety data are conflicting or incomplete. Copper is needed in pregnancy but only in recommended amounts, and chlorophyll's safety in pregnancy is not well established—the data advises against it. Safety during breastfeeding is unknown for chlorophyll. Talk with your doctor or pharmacist for personalized advice before use.
What's the main interaction I should know about?
If you take penicillamine (for Wilson's disease or rheumatoid arthritis), copper in this product will bind to it and reduce its absorption, weakening its effect. You'd need to separate doses by at least 2 hours. Beyond that, the sodium and chlorophyll content can interact with blood pressure medications, lithium, methotrexate, and several other drugs.
Is copper in this supplement safe?
Copper is generally well tolerated in standard supplement amounts, but excess is toxic. The supplement is safe within recommended doses; just avoid high-dose copper supplements unless your doctor advises it. Contact dermatitis from copper has been reported rarely.
Can chlorophyll make me more sensitive to the sun?
Yes. Photosensitization—increased sun sensitivity—is the most common adverse effect reported with chlorophyll. If you take this product, be mindful of sun exposure and use sun protection.
Does this product have any fillers?
Yes. The softgel capsule contains bovine gelatin, glycerin, water, carob, extra virgin olive oil, maltodextrin, and beeswax as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ChlorOxygen Chlorophyll Concentrate Softgels label
Go deeper

The Full Monographs Behind ChlorOxygen Chlorophyll Concentrate Softgels’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Chlorophyll

Interacts with 337 drugs

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...

Read the full Chlorophyll monograph →
Sources

Sources & How We Checked

ChlorOxygen Chlorophyll Concentrate Softgels's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 54 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
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  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
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  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
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See these in context on the Sodium monograph →

Chlorophyll 5 references
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  3. Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

See these in context on the Chlorophyll monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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