Chocamine Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Chocamine Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chocamine Extract is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, high blood pressure, high cholesterol.Based on those ingredients, 1,394 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chocamine Proprietary Cocoa extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chocamine Extract by Nootropics Depot
Ask about any prescription or over-the-counter medication and we check it for interactions with Chocamine Extract by Nootropics Depot — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chocamine Extract by Nootropics Depot
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.
Why this rating?
- The label discloses an exact amount for 0 of its 6 active ingredients.
- “Chocamine Proprietary Cocoa extract” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.
- “Spices” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 4 of the 5 matched ingredients can interact with medications — Allspice, Cocoa, Ginger, Cassia Cinnamon.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
- For scale: 1,395 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 5 of 5.
- General safety write-ups exist for 5 of 5.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chocamine Extract, straight from the product label.
| Brand | Nootropics Depot |
|---|---|
| Net contents | 8.8 Ounce(s); 250 Gram(s) |
| Market status | Off market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 232103 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chocamine Extract by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Theobromine | 0 NP | -- |
| Ginger | 0 NP | -- |
| Cinnamon | 0 NP | -- |
| Tapioca Starch | 0 NP | -- |
| Allspice | 0 NP | -- |
| Chocamine Proprietary Cocoa extract | 1000 mg | -- |
| Cocoa low fat powder extract | 0 NP | -- |
| Spices | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Precautions
Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.
Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food and Drug Administration.
Brand IP Statement(s)
Chocamine is exclusively licensed by RFI, LLC
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1000 mg once daily.
General Statements
Transfer scoops are not accurate forms of measurement . A milligram scale is needed to accurately measure dosages.
Storage
Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chocamine Extract by Nootropics Depot label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chocamine Extract by Nootropics Depot
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Gram(s) Dosage formPowder Servings per container250 Amounts shown are per serving.
Chocamine Proprietary Cocoa extract
Interacts with661 drugs
Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are...
Chocamine Proprietary Cocoa extract monograph & interactions- › Theobromine
- › Tapioca Starch
- › Cocoa low fat powder extract
- › Spices
Chocamine Extract by Nootropics Depot Drug Interactions
Chocamine Extract contains a single active ingredient, and it has known interactions with 1,394 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Chocamine Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chocamine Extract interact with 1,394 drugs. Click any drug to see the details.
1 of the 1 ingredient in Chocamine Extract interact with drugs. Each result below shows which ingredient is responsible. Chocamine Proprietary Cocoa extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Abacavir, Lamivudine interactionAbametapirXeglyze
How Abametapir interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
Cocoa Low Fat Powder ExtractCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Cocoa Low Fat Powder Extract + Abametapir interactionAbciximabReoPro
How Abciximab interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
GingerAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger + Abciximab interactionAllspiceAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Read the full Allspice + Abciximab interactionCocoa Low Fat Powder ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cocoa Low Fat Powder Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Abiraterone interactionCocoa Low Fat Powder ExtractCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Cocoa Low Fat Powder Extract + Abiraterone interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Abiraterone Acetate interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
Cocoa Low Fat Powder ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cocoa Low Fat Powder Extract + Abrocitinib interactionAllspiceAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Read the full Allspice + Abrocitinib interactionGingerAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Chocamine Extract — through 1 ingredient. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acarbose interactionGingerAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acebutolol interactionCocoa Low Fat Powder ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Read the full Cocoa Low Fat Powder Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
AllspiceAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Read the full Allspice + Acenocoumarol interactionGingerAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger + Acenocoumarol interactionCocoa Low Fat Powder ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cocoa Low Fat Powder Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Chocamine Extract — through 4 ingredients. Tap an ingredient for the detail:
AllspiceAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Read the full Allspice + Acetaminophen, Aspirin interactionCocoa Low Fat Powder ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Aspirin interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Aspirin interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Chocamine Extract — through 4 ingredients. Tap an ingredient for the detail:
AllspiceAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Read the full Allspice + Acetaminophen, Aspirin, Caffeine interactionCocoa Low Fat Powder ExtractStimulant Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Aspirin, Caffeine interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Aspirin, Caffeine interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionCocoa Low Fat Powder ExtractStimulant Drugs, Phenylpropanolamine Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Butalbital interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Butalbital, Caffeine interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Butalbital, Caffeine interactionCocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
Cocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Butalbital, Caffeine, Codeine interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Butalbital, Codeine interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Butalbital, Codeine Phosphate interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionCocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Caffeine, Codeine interactionCocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Caffeine, Codeine interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
Cocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Caffeine, Codeine, Salicylamide interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Caffeine, Dihydrocodeine interactionCocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Caffeine, Isometheptene interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Caffeine, Isometheptene interactionCocoa Low Fat Powder ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Chocamine Extract — through 3 ingredients. Tap an ingredient for the detail:
Cocoa Low Fat Powder ExtractStimulant Drugs, Diuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa Low Fat Powder Extract + Acetaminophen, Caffeine, Pyrilamine interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Caffeine, Pyrilamine interactionCinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Chocamine Extract — through 2 ingredients. Tap an ingredient for the detail:
CinnamonHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chocamine Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chocamine Proprietary Cocoa extract
Ace Inhibitors (Aceis)
Theoretically, taking cocoa with ACEIs might increase the risk of adverse effects.
Human research shows that dark chocolate can inhibit ACE. Additionally, prolonged angioedema in an elderly patient on an ACE inhibitor was precipitated with intake of diabetic chocolate.
Adenosine (Adenocard)
Theoretically, cocoa might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.
Alcohol (Ethanol)
Theoretically, concomitant use might increase levels and adverse effects of caffeine.
Cocoa contains caffeine. Alcohol reduces caffeine metabolism. Concomitant use of alcohol can increase caffeine serum concentrations and the risk of caffeine adverse effects.
Anticoagulant/Antiplatelet Drugs
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research shows that intake of cocoa can inhibit platelet adhesion, aggregation, and activity and increase aspirin-induced bleeding time. For patients on dual antiplatelet therapy, cocoa may enhance the inhibitory effect of clopidogrel, but not aspirin, on platelet aggregation.
Antihypertensive Drugs
Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that cocoa can modestly decrease blood pressure in hypertensive and normotensive patients.
Beta-Adrenergic Agonists
Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.
Cocoa contains caffeine. Theoretically, large amounts of caffeine might increase cardiac inotropic effects of beta-agonists. A case of atrial fibrillation associated with consumption of large quantities of chocolate in a patient with chronic albuterol inhalation abuse has also been reported.
Cytochrome P450 1A2 (Cyp1A2) Inhibitors
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from cocoa and increase caffeine levels.
Dipyridamole (Persantine)
Theoretically, cocoa might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.
Disulfiram (Antabuse)
Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
Cocoa contains caffeine. In human research, disulfiram decreases the rate of caffeine clearance.
Diuretic Drugs
Theoretically, using cocoa with diuretic drugs might increase the risk of hypokalemia.
Cocoa contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.
Ephedrine
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Cocoa contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.
Estrogens
Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Estrogen inhibits caffeine metabolism.
Flutamide (Eulexin)
Theoretically, cocoa might increase the levels and adverse effects of flutamide.
Cocoa contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.
Fluvoxamine (Luvox)
Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Fluvoxamine reduces caffeine metabolism.
Lithium
Theoretically, abrupt cocoa withdrawal might increase the levels and adverse effects of lithium.
Cocoa contains caffeine. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Cocoa contains caffeine. Large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.
Nicotine
Theoretically, concomitant use might increase the risk of hypertension.
Cocoa contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.
Pentobarbital (Nembutal)
Theoretically, cocoa might decrease the effects of pentobarbital.
Cocoa contains caffeine. Caffeine might negate the hypnotic effects of pentobarbital.
Phenobarbital (Luminal)
Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.
Phenylpropanolamine
Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Cocoa contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.
Phenytoin (Dilantin)
Theoretically, cocoa might reduce the effects of phenytoin and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.
Quinolone Antibiotics
Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Quinolones (also referred to as fluoroquinolones) decrease caffeine clearance.
Riluzole (Rilutek)
Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Cocoa contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2, and concomitant use might reduce metabolism of one or both agents.
Stimulant Drugs
Theoretically, concomitant use might increase stimulant adverse effects.
Cocoa contains caffeine. Concomitant use might increase the risk of stimulant adverse effects.
Theophylline
Theoretically, cocoa might increase the levels and adverse effects of theophylline.
Cocoa contains caffeine. Large amounts of caffeine might inhibit theophylline metabolism. Caffeine decreases theophylline clearance 23% to 29%.
Brand information
Manufacturer and brand details for Chocamine Extract, from the product label.
Nootropics Depot
See all Nootropics Depot products- Name
- Nootropics Depot
- Street Address
- 8380 S. Kyrene Rd. Ste. 110
- City
- Tempe
- State
- AZ
- ZipCode
- 85284
- Web Address
- nootropicsdepot.com
Chocamine Extract by Nootropics Depot: Common Questions
Does Chocamine Extract by Nootropics Depot interact with any medications?
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Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chocamine Extract is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chocamine Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cocoa
Interacts with 661 drugsCocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are high in sugar, fat, and calories, which...
Read the full Cocoa monograph → Herb & supplement monographTapioca
Tapioca is a starch made from the root of the cassava plant and is mainly used as a food ingredient and gluten-free thickener, not as a medicinal supplement. It is generally safe to eat in n...
Read the full Tapioca monograph →Sources & How We Checked
Chocamine Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 212 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cocoa 119 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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