Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Cholester-Reg II Ingredients & Drug Interactions

by Nature's Sunshine

Cholester-Reg II label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cholester-Reg II against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cholester-Reg II is a dietary supplement by Nature's Sunshine with 5 active ingredients. Its ingredients are commonly taken for high cholesterol, heart and blood vessel health, leg pain from poor circulation (intermittent claudication).Based on those ingredients, 1,075 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Japanese Knotweed Root Extract, Artichoke, Policosanol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cholester-Reg II by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Cholester-Reg II by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cholester-Reg II by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (462 mg) without saying how much of each component you get.

Cholester-Reg II contains five active ingredients designed to support cholesterol and circulatory health. Policosanol is a plant-derived compound that may help with walking distance in circulation issues.

Japanese Knotweed Root Extract (hu zhang) is a traditional herb containing resveratrol. Inositol nicotinate is a form of niacin that converts to niacin in your body.

Artichoke leaf extract is included for its potential effects on cholesterol and digestion. The product also includes a proprietary blend (meaning the exact doses of some ingredients aren't listed separately).

Inactive ingredients—capsule materials, cellulose, magnesium stearate, stearic acid, silicon dioxide, gelatin, and water—are fillers and binders that hold the supplement together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support normal range cholesterol levels.
  • We looked for evidence on: Hyperlipidemia, Familial hypercholesterolemia, Coronary heart disease (CHD), Metabolic syndrome, dyslipidemia, atherosclerosis prevention.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Policosanol is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Familial hypercholesterolemia, Metabolic syndrome.
  • Also on file: Inositol Nicotinate is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Policosanol is likely effective for intermittent claudication (difficulty walking due to poor leg circulation), based on clinical research. The evidence for policosanol in coronary heart disease and familial high cholesterol is insufficient to rate.

Artichoke leaf extract is possibly effective for high cholesterol and indigestion (dyspepsia), with limited clinical evidence. Inositol nicotinate is possibly effective for Raynaud syndrome (a condition affecting blood flow to the fingers), though evidence for other conditions is insufficient.

Japanese Knotweed Root Extract has insufficient evidence for the conditions listed in our data—hepatitis, rheumatoid arthritis, wound healing, gout, osteoarthritis, and unstable angina. Phytosterols' effectiveness data is not on file.

The evidence, ingredient by ingredient Policosanol Hu Zhang Inositol Nicotinate Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Policosanol is generally well tolerated in studies, though real-world benefit is uncertain and quality varies between brands. Uncommon side effects include headache, dizziness, sleepiness, irritability, insomnia, and weight loss; nausea and upset stomach may also occur.

Pregnancy and breastfeeding safety data for policosanol are insufficient—the safety data advises against use during pregnancy and while breastfeeding. Japanese Knotweed Root Extract is traditionally used but has limited human safety data; its emodin content may cause digestive upset.

Pregnancy and breastfeeding safety are not established. Inositol nicotinate is generally tolerated short-term but evidence is limited; high-dose niacin compounds can affect the liver.

Pregnancy and breastfeeding safety have not been established. Artichoke is generally well tolerated but quality and dosing vary by product.

Common side effects are abdominal pain, diarrhea, gas, and nausea. Rare severe reactions (anaphylaxis) have been reported in people sensitive to inulin; those allergic to ragweed, daisies, and related plants face higher risk.

Pregnancy and breastfeeding safety data are not established.

Side effects, ingredient by ingredient Policosanol Hu Zhang Inositol Nicotinate Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Policosanol, Inositol Nicotinate, Artichoke, Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,076 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Cholester-Reg II, check with your doctor or pharmacist if you take any of these: blood pressure medications (especially beta-blockers like propranolol), blood thinners or antiplatelet drugs (including warfarin), diabetes medications, cholesterol-lowering statins, drugs metabolized by liver enzymes (CYP1A2, CYP2C19, CYP3A4, CYP2E1, CYP2B6, or CYP2B6 substrates), estrogen replacement therapy, transdermal nicotine patches, or carbamazepine. These are the primary medication types with documented or theoretical interactions at Moderate or Minor severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cholester-Reg II may be worth considering if you have high cholesterol or poor leg circulation and want to explore plant-based options—policosanol has the strongest evidence for walking distance in circulation issues, and artichoke may help with cholesterol and digestion. However, this product interacts with numerous medications, especially blood pressure drugs, blood thinners, diabetes medications, and cholesterol-lowering statins.

Before you start, run your medications through the checker on this page and talk with your doctor or pharmacist to make sure it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cholester-Reg II, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904005570
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 278058
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cholester-Reg II by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
099904005570
IngredientAmount% DV
Phytosterols0 NP--
Policosanol0 NP--
Japanese Knotweed Root Extract0 NP--
Proprietary Blend462 mg--
Inositol Nicotinate0 NP--
Artichoke0 NP--

Other ingredients: Capsule, Cellulose, Magnesium Stearate, Stearic Acid, Silicon Dioxide, Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.

New look! Same great product

Formula

This natural policosanol and phytosterol product has been formulated to support normal range cholesterol levels in combination with a healthy diet and exercise.

Precautions

Warning: Do not take this product if pregnant or lactating. Consult your health care professional before using if you are currently taking any cholesterol-lowering agents.

Cholesterol levels should be checked regularly. For adults 20 years of age or older only.

Keep out of the reach of children.

Do not use if inner seal is missing or damaged.

Formulation

Circulatory system support Supports normal-range cholesterol levels

Guaranteed pure

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Natures Sunshine Herbal experts since 1972

Suggested/Recommended/Usage/Directions

Recommended Use: Take 1 capsule with a meal three times daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cholester-Reg II by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cholester-Reg II label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cholester-Reg II by Nature's Sunshine

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

462 mg per serving

Other (inactive) ingredients: Capsule, Cellulose, Magnesium Stearate, Stearic Acid, Silicon Dioxide, Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cholester-Reg II by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Cholester-Reg II?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,075Drugs
1,075 Moderate

Ingredients driving the most interactions

Japanese Knotweed Root Extract 826
Artichoke 363
Policosanol 242
Inositol Nicotinate 223

Individual Drug Interactions

The ingredients in Cholester-Reg II interact with 1,075 drugs. Click any drug to see the details.

4 of the 5 ingredients in Cholester-Reg II interact with drugs. Each result below shows which ingredient is responsible. Japanese Knotweed Root Extract Artichoke Policosanol Inositol Nicotinate

Each ingredient & the kinds of drugs it affects

For each ingredient in Cholester-Reg II with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Japanese Knotweed Root Extract7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Japanese Knotweed Root Extract full monograph & interactions

Artichoke4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke full monograph & interactions

Policosanol6 drug types · 242 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. Although, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response. Furthermore, a study in patients undergoing percutaneous coronary intervention with a drug-eluting stent found that taking policosanol 40 mg plus clopidogrel and aspirin daily for 30 days modestly reduced the risk for minor bleeding events when compared with taking clopidogrel and aspirin alone. Until more is known, use with caution.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Clinical research shows that policosanol can lower blood glucose levels.

Likelihood Possible Evidence B
Beta-Blockers

Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.
Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the blood-pressure lowering effects of propranolol.

Likelihood Probable Evidence A
Nitroprusside (Nitropress)

Theoretically, concomitant use of policosanol with nitroprusside might cause additive blood pressure-lowering effects.
Animal research shows that taking policosanol along with nitroprusside can increase the blood pressure-lowering effects of nitroprusside.

Likelihood Possible Evidence D
Propranolol (Inderal)

Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking policosanol with warfarin might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response.

Likelihood Possible Evidence B
Policosanol full monograph & interactions

Inositol Nicotinate4 drug types · 223 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Inositol nicotinate has fibrinolytic effects, which may increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Inositol nicotinate is metabolized to niacin in the body. Niacin can cause hyperglycemia, abnormal glucose tolerance, and glycosuria. Increased blood glucose monitoring may be necessary, particularly early in the course of treatment.

Likelihood Probable Evidence B
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of inositol nicotinate and statins might increase the risk of myopathy and rhabdomyolysis.
Inositol nicotinate is metabolized to niacin in the body. Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins However, a significantly increased risk of myopathy has not been demonstrated in clinical trials.

Likelihood Possible Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of inositol nicotinate and transdermal nicotine might increase the risk of flushing and dizziness.
Inositol nicotinate is metabolized to niacin in the body. Inositol nicotinate and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Inositol Nicotinate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cholester-Reg II, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Cholester-Reg II by Nature's Sunshine: Common Questions

Does Cholester-Reg II by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Cholester-Reg II has a known interaction with 1,075 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cholester-Reg II contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is policosanol safe to take if I'm on a blood pressure medication?
Policosanol can lower blood pressure on its own, and combining it with blood pressure drugs—especially beta-blockers—may cause a bigger drop than intended. Talk with your doctor or pharmacist before adding this product; they may need to monitor your blood pressure or adjust your medication dose.
What side effects might I notice from policosanol?
Most people tolerate it well. Uncommon side effects include headache, dizziness, sleepiness, trouble sleeping, irritability, or weight loss. Nausea and upset stomach may also happen. These are usually mild, but let your healthcare provider know if any bother you.
Can I take this if I'm on a blood thinner like warfarin?
This product contains multiple ingredients that theoretically increase bleeding risk when combined with blood thinners. Don't start it without checking with your doctor or pharmacist first—they'll need to weigh the benefit against the risk and possibly monitor you more closely.
Is Cholester-Reg II safe during pregnancy or while breastfeeding?
The safety data for policosanol, Japanese Knotweed, inositol nicotinate, and artichoke during pregnancy and breastfeeding are not established. The safety data advises against policosanol in both situations. Talk with your doctor or pharmacist before using this product if you are pregnant or nursing.
Does this product actually lower cholesterol?
Policosanol has insufficient evidence to rate for coronary heart disease, and artichoke is possibly effective for high cholesterol based on limited studies. Neither ingredient is proven to lower cholesterol significantly. Check with your doctor about whether this should be part of your cholesterol plan.
Are there any fillers or other inactive ingredients I should know about?
Yes. The capsule contains cellulose, magnesium stearate, stearic acid, silicon dioxide, gelatin, and water. These are standard inactive ingredients; if you're sensitive to any of them, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cholester-Reg II is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cholester-Reg II label
Go deeper

The Full Monographs Behind Cholester-Reg II’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Policosanol

Interacts with 242 drugs

Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to lower cholesterol. Early studies from Cuba...

Read the full Policosanol monograph → Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph → Herb & supplement monograph

Inositol Nicotinate

Interacts with 223 drugs

Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation. Evidence that it works as well as regular niacin is weak and inconsistent, and it is not a proven...

Read the full Inositol Nicotinate monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Cholester-Reg II's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Policosanol 15 references
  1. Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
  2. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  3. Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
  4. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
  5. Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
  6. Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
  7. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
  8. Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
  9. Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
  10. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
  11. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
  12. Fernandez L, Mas R, Illnait J, Fernandez JC. Policosanol: results of a postmarketing surveillance study of 27,879 patients. Curr Ther Res 1998;59(10):717-22. DOI
  13. Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
  14. Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
  15. Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed

See these in context on the Policosanol monograph →

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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