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Dietary supplement

Cholesterol Support Ingredients & Drug Interactions

by GNC Preventive Nutrition

Cholesterol Support label
See full label image
Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cholesterol Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cholesterol Support is a dietary supplement by GNC Preventive Nutrition with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cholesterol Support by GNC Preventive Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Cholesterol Support by GNC Preventive Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cholesterol Support by GNC Preventive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

GNC Preventive Nutrition Cholesterol Support is a single-ingredient supplement. The active ingredient is pantethine, a form of pantothenic acid (vitamin B5) that your body can convert to coenzyme A, a molecule involved in fat metabolism and energy production.

The capsule also contains several inactive ingredients: vegetable cellulose, cellulose, stearic acid, magnesium stearate, and silica. These are standard binders, fillers, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports normal healthy cholesterol levels.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, dyslipidemia, triglyceridemia.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Pantethine carries a "Possibly Effective" rating for hyperlipoproteinemia (a disorder of blood fats). For other forms of high cholesterol (hyperlipidemia), the evidence we hold is rated Insufficient Reliable Evidence To Rate—meaning the existing studies don't yet establish whether it works.

Athletic performance and a rare genetic disorder (PKAN) also lack reliable evidence. If you're considering this product for cholesterol support, talk with your doctor about whether the existing evidence is enough for your situation and how it might fit with other approaches.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild gastrointestinal complaints: nausea, vomiting, diarrhea, bloating, flatulence, and epigastric discomfort (upper belly pain).

Mild itching has been reported rarely. Not enough reliable safety data exists for pregnancy or breastfeeding.

The safety notes advise against use in pregnancy unless your doctor specifically advises otherwise. For breastfeeding, safety has not been well studied, so caution is advised.

Talk with your doctor or pharmacist about whether this supplement fits your situation.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any blood thinners or antiplatelet drugs you take—pantethine may theoretically increase bleeding risk with these medications. Altogether, these interactions span 122 individual medications.

Run your exact prescriptions through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GNC Preventive Nutrition Cholesterol Support may be worth considering if you have hyperlipoproteinemia and your doctor thinks pantethine is appropriate. If you take a blood thinner or antiplatelet drug, check your exact medications with the search tool on this page before starting.

If you're pregnant, breastfeeding, or planning either, speak with your doctor or pharmacist first—the safety data are too limited to say it's okay on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cholesterol Support, straight from the product label.

Brand GNC Preventive Nutrition
Barcode (UPC) 048107161439
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 67165
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cholesterol Support by GNC Preventive Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
048107161439
IngredientAmount% DV
Pantethine300 mg--

Other ingredients: Vegetable Cellulose Capsule, Cellulose, Stearic Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

General Statements

New

Physician formulated nutrition solutions - Supports normal healthy cholesterol levels with clinically proven dose

Physician endorsed

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

This product is endorsed by the physicians on the GNC Medical Advisory Board.

Brand IP Statement(s)

Powered by Pantesin

Pantesin is a registered trademark of Kyowa Pharma Chemical Co. Ltd.

FDA Statement of Identity

Dietary Supplement

General

CODE 619411 GQG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule twice daily. For optimal results, use in conjunction with a low-cholesterol diet.

Formulation

No Sugar, no Starch, no Artificial Colors, no Artificial Flavors, no Preservatives, Sodium free, no Wheat, Gluten free, no Corn, no Soy, no Dairy, Yeast free.

Seals/Symbols

Gf Gluten free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cholesterol Support by GNC Preventive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cholesterol Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cholesterol Support by GNC Preventive Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Pantethine

Interacts with
122 drugs
300 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule, Cellulose, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cholesterol Support by GNC Preventive Nutrition Drug Interactions

Want to check YOUR meds against Cholesterol Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Cholesterol Support interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cholesterol Support interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Cholesterol Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cholesterol Support, from the product label.

GNC Preventive Nutrition

See all GNC Preventive Nutrition products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Cholesterol Support by GNC Preventive Nutrition: Common Questions

Does Cholesterol Support by GNC Preventive Nutrition interact with any medications?
Yes. Based on its ingredients, Cholesterol Support has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cholesterol Support contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine and why is it in this product?
Pantethine is a form of pantothenic acid (vitamin B5) that your body converts to coenzyme A, a molecule that helps your body process fats and produce energy. It's included in this product because evidence suggests it may help with a blood-fat disorder called hyperlipoproteinemia.
Does this actually work for high cholesterol?
Pantethine is rated "Possibly Effective" for hyperlipoproteinemia, but for other types of high cholesterol (hyperlipidemia), the evidence is not yet established. Talk with your doctor about whether the current evidence fits your needs.
What side effects might I experience?
The most common side effects are mild stomach issues: nausea, vomiting, diarrhea, bloating, flatulence, and upper belly discomfort. Itching has been reported but is rare. Pantethine is generally well tolerated overall.
Is it safe to take while pregnant or breastfeeding?
Not enough reliable safety data exist for either. The safety notes advise against use in pregnancy unless your doctor advises otherwise, and caution is advised during breastfeeding. Talk with your doctor or pharmacist about your specific situation.
Does this product have fillers?
Yes. Aside from the active pantethine, the capsule contains vegetable cellulose, cellulose, stearic acid, magnesium stearate, and silica—these are standard inactive ingredients used as binders and capsule material.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cholesterol Support label
Go deeper

The Full Monographs Behind Cholesterol Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Cholesterol Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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