Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Colon Care Ingredients & Drug Interactions

by GNC Preventive Nutrition

Colon Care label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Colon Care against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Colon Care is a dietary supplement by GNC Preventive Nutrition with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Colon Care by GNC Preventive Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Colon Care by GNC Preventive Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Colon Care by GNC Preventive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Colon Care has five active ingredients. Lactobacillus acidophilus is a beneficial bacteria (probiotic) meant to support digestive and gut health.

Fructooligosaccharides (FOS) are a type of fiber that can feed the good bacteria already in your gut. The other three — psyllium seed husks powder, oat bran powder, and wheat bran powder — are all high-fiber ingredients designed to add bulk and support regular bowel movements.

The product also contains inactive ingredients (cellulose, whey powder, and gelatin) used as binders and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Helps promote a healthy colon.
  • We looked for evidence on: Colorectal cancer, Constipation, Hemorrhoids, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Colon health — and 2 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Wheat Bran is rated "Possibly Effective" for Constipation, Hemorrhoids, Irritable bowel syndrome (IBS).
  • Also on file: Wheat Bran is rated "Possibly Ineffective" for Colorectal cancer.

The evidence is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis — meaning there's some supporting research, but it's not definitive.

Wheat bran is possibly effective for constipation, hemorrhoids, and irritable bowel syndrome. For fructooligosaccharides, the evidence we hold doesn't establish how well it works for any condition — the data rates it as insufficient to say either way.

The same goes for psyllium seed husks and oat bran; we don't hold effectiveness ratings for those ingredients.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos) Wheat Bran

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though gastrointestinal side effects like bloating, gas, abdominal pain, and diarrhea can happen — they're just uncommon. In rare cases, the live bacteria have been linked to serious infections in vulnerable patients; most of these cases involved bacteria that naturally live in the body moving to places they shouldn't.

Fructooligosaccharides often cause gas, bloating, and abdominal pain, especially at higher doses, though studies show doses under 10 grams daily are generally mild. Wheat bran is generally well tolerated as a food and likely safe in pregnancy and lactation, but it contains gluten and can cause allergic reactions in sensitive people; flatulence and GI discomfort may happen at first but often improve.

All three ingredients suggest you talk with your doctor before use.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos) Wheat Bran

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, don't take them at the same time as this product — space them apart so the antibiotics don't kill off the live probiotic organisms. Ask your pharmacist how far apart works best.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a gut-support blend aimed at digestive regularity and probiotic health. It's a reasonable choice if you're looking to add fiber and beneficial bacteria, but the evidence for most ingredients is modest.

If you take antibiotics, you'll need to space them out from the probiotic — ask your pharmacist about timing. Check with your doctor first, especially if you have wheat sensitivity or a compromised immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Colon Care, straight from the product label.

Brand GNC Preventive Nutrition
Barcode (UPC) 048107046866
Net contents 240 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 1834
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, Qualified Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Colon Care by GNC Preventive Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
80
UPC/BARCODE
048107046866
IngredientAmount% DV
Lactobacillus acidophilus200 mg--
Fructooligosaccharides500 mg--
Psyllium seed husks powder400 mg--
Oat Bran powder200 mg--
Wheat Bran Powder200 mg--

Other ingredients: Cellulose, Whey powder, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take three capsules daily after a meal.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

CONTAINS: Milk and Wheat.

Discontinue use two weeks prior to surgery.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

General Statements

A unique combination of fiber, acidophilus and FOS

Conforms to USP <2091> for weight.

DIGESTION

Helps promote a healthy colon*

Meets USP <2040> disintegration.

The colon is among the most active organs in the body, responsible for the final stages of digestion. The delicate colon walls extract the majority of nutrients and water from food for use by the body.

Brand IP Statement(s)

Preventive Nutrition(R) Colon Care provides a comprehensive approach to caring for your colon. It contains three plant-source fibers, including psyllium, which helps clean the colon. Fructooligosaccharides (FOS) is a natural plant-based food source for acidophilus and helps establish a healthy environment in which those organisms can flourish in the intestines.* Acidophilus helps maintain a healthy digestive tract.* Working together, these premium indredients may benefit long-term colon health.

Formulation

No Artificial Colors, No Artifical Flavors, No Soy.

FDA Statement of Identity

DIETARY SUPPLEMENT

General

CODE 725621 KLG

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Colon Care by GNC Preventive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Colon Care label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Colon Care by GNC Preventive Nutrition

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container80 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus acidophilus

Interacts with
182 drugs
200 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Fructooligosaccharides

No known
interactions
500 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Psyllium seed husks powder

400 mg per serving

Oat Bran powder

200 mg per serving

Wheat Bran Powder

No known
interactions
200 mg per serving

Wheat bran is the fiber-rich outer layer of the wheat kernel and is best known as a natural bulk-forming way to relieve constipation and support regul...

Wheat Bran Powder monograph & interactions

Other (inactive) ingredients: Cellulose, Whey powder, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Colon Care by GNC Preventive Nutrition Drug Interactions

Want to check YOUR meds against Colon Care?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Colon Care interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in Colon Care interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Colon Care with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Colon Care, from the product label.

GNC Preventive Nutrition

See all GNC Preventive Nutrition products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Colon Care by GNC Preventive Nutrition: Common Questions

Does Colon Care by GNC Preventive Nutrition interact with any medications?
Yes. Based on its ingredients, Colon Care has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Colon Care contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my constipation?
Wheat bran in this formula is possibly effective for constipation, and the fiber content overall is meant to support regularity. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, which sometimes involves constipation. That said, the evidence isn't ironclad, so results can vary — talk to your doctor about whether it's right for you.
What if I'm taking antibiotics right now?
Don't take this product at the same time as your antibiotic. The antibiotic will kill the live bacteria in the probiotic, making it less effective. Space them out — your pharmacist can tell you exactly how far apart to take them.
Can I take this while pregnant?
Lactobacillus acidophilus is possibly safe in pregnancy. Wheat bran is likely safe. We don't have pregnancy safety data on file for fructooligosaccharides, psyllium seed husks, or oat bran. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Will it cause gas and bloating?
Yes, it might. Both fructooligosaccharides and wheat bran commonly cause gas, bloating, and abdominal pain, especially when you first start or if you take higher doses. The good news is these side effects are usually mild and often improve over time.
Does this product contain gluten?
Yes — wheat bran contains gluten. The product notes say it should be increased slowly with plenty of fluids, and you should check with your doctor before using it if you have wheat sensitivity.
Are there any fillers or other junk in here?
The inactive ingredients are cellulose, whey powder, and gelatin — these are binders and capsule material, pretty standard stuff. If you're allergic to any of those, let us know and we can suggest something else.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Colon Care is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Colon Care label
Go deeper

The Full Monographs Behind Colon Care’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Wheat Bran

Wheat bran is the fiber-rich outer layer of the wheat kernel and is best known as a natural bulk-forming way to relieve constipation and support regular bowel movements. It is generally safe...

Read the full Wheat Bran monograph →
Sources

Sources & How We Checked

Colon Care's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Wheat Bran 4 references
  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. McRorie J, Kesler J, Bishop L, et al. Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms. Am J Gastroenterol 2000;95:1244-52. PubMed
  3. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
  4. Dalile B, La Torre D, Kalc P, et al. Extruded Wheat Bran Consumption Increases Serum Short-Chain Fatty Acids but Does Not Modulate Psychobiological Functions in Healthy Men: A Randomized, Placebo-Controlled Trial. Front Nutr 2022;9:896154. PubMed

See these in context on the Wheat Bran monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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