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Dietary supplement

Choline Bitartrate with Betaine HCl Ingredients & Drug Interactions

by Roex

Choline Bitartrate with Betaine HCl label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline Bitartrate with Betaine HCl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline Bitartrate with Betaine HCl is a dietary supplement by Roex with 2 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 52 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride, Choline Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline Bitartrate with Betaine HCl by Roex

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline Bitartrate with Betaine HCl by Roex — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline Bitartrate with Betaine HCl by Roex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: betaine hydrochloride and choline bitartrate. Betaine hydrochloride is a form of betaine paired with hydrochloric acid to increase stomach acidity, while choline bitartrate is a form of choline, a nutrient involved in brain function and cell structure.

The capsule also contains inactive ingredients — hydroxypropyl methylcellulose, stearic acid, silica, and magnesium stearate — which are fillers and binders that hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: brain, memory, nerve, bladder and kidney function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, Infant development, Neural tube birth defects — and 3 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Nonalcoholic fatty liver disease (NAFLD), Cognitive function, Dementia, and more.

The evidence for what this product does isn't established in the data we hold. For betaine hydrochloride, we have insufficient reliable evidence to rate its use for indigestion (dyspepsia), low thyroid function (hypothyroidism), diarrhea, rheumatoid arthritis, food allergies, or hay fever (allergic rhinitis).

For choline bitartrate, the evidence we have suggests it's possibly ineffective for athletic performance, and we lack reliable evidence for its use in bronchitis, age-related cognitive decline, liver damage from total parenteral nutrition, hay fever, or Alzheimer disease.

The evidence, ingredient by ingredient Betaine Hydrochloride Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride carries real caution. It may irritate your stomach and is not safe if you have ulcers, gastritis, or acid reflux — the added acid can make those conditions worse or slow healing.

It may also cause heartburn. Do not use this ingredient during pregnancy; there isn't enough safety data.

Avoid it while breastfeeding as well. Choline bitartrate is generally well tolerated in normal amounts, but high doses over the tolerable upper limit of 3.5 grams daily can cause side effects.

At very high doses (9 grams or more), people have reported diarrhea, nausea, vomiting, sweating, and a fishy body odor from how your gut breaks it down. While choline is important in pregnancy and breastfeeding, use only the dose your doctor or midwife recommends, not arbitrary supplement amounts.

Side effects, ingredient by ingredient Betaine Hydrochloride Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride, Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 52 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take H2-blockers, antacids, or proton pump inhibitors (PPIs) — betaine hydrochloride may reduce how well they work. Also check if you use atropine.

Because the interaction data is specific to these drug types, run your exact medications through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This two-ingredient product is worth considering only if your doctor has suggested betaine or choline for a specific reason and you've confirmed you don't take acid-reducing medications or atropine. If you have stomach ulcers, gastritis, or acid reflux, steer clear of betaine hydrochloride.

Talk with your own doctor or pharmacist before starting this supplement, especially if you're pregnant, breastfeeding, or take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline Bitartrate with Betaine HCl, straight from the product label.

Brand Roex
Barcode (UPC) 045245371201
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 211487
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline Bitartrate with Betaine HCl by Roex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
045245371201
IngredientAmount% DV
Betaine Hydrochloride500 mg--
Choline Bitartrate1000 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Stearic Acid, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Choline Bitartrate allows the body to manufacture the neurotransmitter acetylcholine, which assists in bladder, kidney, pancreatic, testicular, and liver functions. It also aids in hormone production and has been shown to help boost the libido. Roex has added Betaine HCl to help increase the secretion of HCl from the stomach's parietal cells, which is critical for proper digestion of proteins and the emulsification of fats.

Contains Betaine HCl for proper digestion and breakdown of proteins and fats

Precautions

Warning: Consult your physician prior to use if you are pregnant, nursing, have a medical condition or are taking medications.

Not intended for children.

Keep out of the reach of children.

Do not use if clear safety seal around bottle neck is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Essential for healthy brain, memory and nerve function Supports healthy bladder and kidney function

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults, take 2 capsules in the morning with breakfast and 2 capsules with dinner, with 8 ounces of water. Take as dietary supplement or as directed by your doctor.

Storage

Store at room temperature, in a dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline Bitartrate with Betaine HCl by Roex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline Bitartrate with Betaine HCl label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline Bitartrate with Betaine HCl by Roex

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
500 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Choline Bitartrate

Interacts with
16 drugs
1000 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline Bitartrate monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Stearic Acid, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline Bitartrate with Betaine HCl by Roex Drug Interactions

Want to check YOUR meds against Choline Bitartrate with Betaine HCl?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
52Drugs
52 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36
Choline Bitartrate 16

Individual Drug Interactions

The ingredients in Choline Bitartrate with Betaine HCl interact with 52 drugs. Click any drug to see the details.

2 of the 2 ingredients in Choline Bitartrate with Betaine HCl interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride Choline Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline Bitartrate with Betaine HCl with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline Bitartrate with Betaine HCl, from the product label.

Roex

See all Roex products
Name
BIN Science LLC
Street Address
8310 South Valley Highway, St. 300
City
Englewood
State
CO
ZipCode
80112
Phone Number
800-645-0010
Web Address
www.roex.com
Pharmacist Counseling Corner

Choline Bitartrate with Betaine HCl by Roex: Common Questions

Does Choline Bitartrate with Betaine HCl by Roex interact with any medications?
Yes. Based on its ingredients, Choline Bitartrate with Betaine HCl has a known interaction with 52 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline Bitartrate with Betaine HCl contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux?
No. Betaine hydrochloride increases stomach acid and is not safe for people with acid reflux, gastritis, or ulcers — it can irritate these conditions or slow healing. Talk with your doctor about alternatives.
Is this safe during pregnancy?
Betaine hydrochloride should be avoided in pregnancy due to insufficient safety data. Choline is important during pregnancy, but you should use only the dose your doctor recommends, not a random supplement amount. Discuss with your doctor before taking this product.
What side effects might I get from the choline in this?
At normal doses, choline is generally well tolerated. At high doses over 3.5 grams daily, some people report a fishy body odor, and at doses of 9 grams or more, nausea, vomiting, diarrhea, sweating, and salivation have been reported.
What does betaine hydrochloride do?
Betaine hydrochloride increases stomach acid. The evidence for its claimed uses — like indigestion, low thyroid function, diarrhea, arthritis, or allergies — is insufficient, so we don't know how well it works for those purposes.
Does choline actually help with cognition or brain health?
The evidence we hold doesn't show that choline bitartrate is effective for athletic performance, and we lack reliable evidence for age-related cognitive decline, Alzheimer disease, or other brain-related uses. Its actual benefit isn't established in our data.
Is this safe while breastfeeding?
Betaine hydrochloride should be avoided while breastfeeding — safety hasn't been established. Choline needs are higher while breastfeeding, but use supplements only under professional guidance. Talk with your doctor or lactation consultant before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline Bitartrate with Betaine HCl label
Go deeper

The Full Monographs Behind Choline Bitartrate with Betaine HCl’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline Bitartrate with Betaine HCl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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